Neuroprotective effects of gangliosides may involve inhibition of nitric oxide synthase

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

1990 • 3,304 citations

Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.

1988 • 2,865 citations

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

1991 • 2,173 citations

Gases as biological messengers: nitric oxide and carbon monoxide in the brain

1994 • 1,052 citations

Recovery of Motor Function after Spinal-Cord Injury — A Randomized, Placebo-Controlled Trial with GM-1 Ganglioside

1991 • 570 citations

Gangliosides prevent glutamate and kainate neurotoxicity in primary neuronal cultures of neonatal rat cerebellum and cortex.

1988 • 384 citations

Ganglioside inhibition of glutamate-mediated protein kinase C translocation in primary cultures of cerebellar neurons.

1987 • 309 citations

Abusive stimulation of excitatory amino acid receptors: a strategy to limit neurotoxicity

1990 • 152 citations

Glutamate-induced neuronal death in primary cultures of cerebellar granule cells: protection by synthetic derivatives of endogenous sphingolipids.

1990 • 132 citations

A Review and Predictive Models of Gang ioside Uptake by Biological Membranes

1993 • 111 citations

Calmodulin, a ganglioside-binding protein. Binding of gangliosides to calmodulin in the presence of calcium.

1992 • 69 citations

Mechanism for ganglioside-mediated modulation of a calmodulin-dependent enzyme. Modulation of calmodulin-dependent cyclic nucleotide phosphodiesterase activity through binding of gangliosides to calmodulin and the enzyme.

1992 • 57 citations

GM-1 ganglioside in human spinal cord injury.

1992 • 40 citations

Soluble Gangliosides in Cultured Neurotumor Cells

1983 • 36 citations

Rapid Internalization and Intracellular Metabolic Processing of Exogenous Ganglioside by Cerebellar Granule Cells Differentiated in Culture

1991 • 31 citations

Gangliosides: New Generation of Neuroprotective Agents

1992 • 14 citations