Nitric oxide as a unique signaling molecule in the vascular system: a historical overview.

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

1987 • 5,027 citations

Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor

1986 • 2,416 citations

Role of endothelium-derived nitric oxide in the regulation of blood pressure.

1989 • 1,837 citations

Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates.

1981 • 1,624 citations

Flow-induced release of endothelium-derived relaxing factor

1986 • 1,379 citations

Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacologic and chemical properties identical to those of nitric oxide radical.

1987 • 1,182 citations

Nitric Oxide as a Mediator of Relaxation of the Corpus Cavernosum in Response to Nonadrenergic, Noncholinergic Neurotransmission

1992 • 1,028 citations

Biological actions and properties of endothelium-derived nitric oxide formed and released from artery and vein.

1989 • 977 citations

Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle

1990 • 854 citations

Stimulation of guanylate cyclase by sodium nitroprusside, nitroglycerin and nitric oxide in various tissue preparations and comparison to the effects of sodium azide and hydroxylamine.

1977 • 692 citations

The Pharmacological and Physiological Role of Cyclic GMP in Vascular Smooth Muscle Relaxation

1985 • 685 citations

Evidence for the inhibitory role of guanosine 3', 5'-monophosphate in ADP-induced human platelet aggregation in the presence of nitric oxide and related vasodilators

1981 • 629 citations

Endothelium‐dependent inhibition of platelet aggregation

1986 • 540 citations

Relationship between cyclic guanosine 3':5'-monophosphate formation and relaxation of coronary arterial smooth muscle by glyceryl trinitrate, nitroprusside, nitrite and nitric oxide: effects of methylene blue and methemoglobin.

1981 • 527 citations

Shear stress-induced release of nitric oxide from endothelial cells grown on beads.

1991 • 488 citations

Mechanism of tolerance development to organic nitrates.

1973 • 486 citations

Relaxation of bovine coronary artery and activation of coronary arterial guanylate cyclase by nitric oxide, nitroprusside and a carcinogenic nitrosoamine.

1979 • 444 citations

NG-methylarginine, and inhibitor of endothelium-derived nitric oxide synthesis, is a potent pressor agent in the guinea pig: Does nitric oxide regulate blood pressure in vivo?

1989 • 438 citations

Activation of purified soluble guanylate cyclase by endothelium-derived relaxing factor from intrapulmonary artery and vein: stimulation by acetylcholine, bradykinin and arachidonic acid.

1986 • 397 citations

Negative feedback regulation of endothelial cell function by nitric oxide.

1993 • 371 citations

Flow-dependent, endothelium-mediated dilation of epicardial coronary arteries in conscious dogs: effects of cyclooxygenase inhibition.

1984 • 367 citations

Prevention and Reversal of Nitrate Tolerance in Patients with Congestive Heart Failure

1987 • 366 citations

Requirement of thiols for activation of coronary arterial guanylate cyclase by glyceryl trinitrate and sodium nitrite possible involvement of S-nitrosothiols

1980 • 313 citations

Intracellular pH and Tyrosine Phosphorylation but Not Calcium Determine Shear Stress–Induced Nitric Oxide Production in Native Endothelial Cells

1996 • 287 citations

Activation of purified guanylate cyclase by nitric oxide requires heme comparison of heme-deficient, heme-reconstituted and heme-containing forms of soluble enzyme from bovine lung

1982 • 262 citations

Sulfhydryl requirement for relaxation of vascular smooth muscle.

1973 • 254 citations

Constitutive nitric oxide synthase from cerebellum is reversibly inhibited by nitric oxide formed from L-arginine

1992 • 254 citations

Regulation of soluble guanylate cyclase activity by porphyrins and metalloporphyrins.

1984 • 220 citations

Activation of purified soluble guanylate cyclase by protoporphyrin IX.

1982 • 206 citations

Reactive dilation of large coronary arteries in conscious dogs.

1984 • 206 citations

Neuronal Nitric Oxide Synthase Self-inactivates by Forming a Ferrous-Nitrosyl Complex during Aerobic Catalysis

1995 • 195 citations

Potentiation of the cardiovascular effects of nitroglycerin by N-acetylcysteine.

1983 • 192 citations

Inhibition of human platelet aggregation by S-nitrosothiols. Heme-dependent activation of soluble guanylate cyclase and stimulation of cyclic GMP accumulation.

1983 • 184 citations

Guanylate cyclase from bovine lung. A kinetic analysis of the regulation of the purified soluble enzyme by protoporphyrin IX, heme, and nitrosyl-heme.

1982 • 182 citations

Decomposition ofS-Nitrosoglutathione in the Presence of Copper Ions and Glutathione

1996 • 176 citations

Possible involvement of S‐nitrosothiols in the activation of guanylate cyclase by nitroso compounds

1980 • 173 citations

In Vivo Induction and Reversal of Nitroglycerin Tolerance in Human Coronary Arteries

1987 • 169 citations

Calcium-Independent Modulation of Cyclic GMP and Activation of Guanylate Cyclase by Nitrosamines

1976 • 160 citations

Endothelium-dependent modulation of cGMP levels and intrinsic smooth muscle tone in isolated bovine intrapulmonary artery and vein.

1987 • 157 citations

Calcium-Dependent and Calcium-Independent Activation of the Endothelial NO Synthase

1997 • 150 citations

Tolerance towards nitroglycerin, induced in vivo, is correlated to a reduced cGMP response and an alteration in cGMP turnover

1983 • 140 citations

Nitric oxide and cGMP: mediators of pelvic nerve-stimulated erection in dogs

1993 • 118 citations

Biosynthesis of nitric oxide and citrulline from l-arginine by constitutive nitric oxide synthase present in rabbit corpus cavernosum

1992 • 117 citations

Vascular tolerance to nitroglycerin and cyclic GMP generation in rat aortic smooth muscle.

1982 • 114 citations

Potentiation of nitroglycerin-induced coronary dilatation by N-acetylcysteine.

1986 • 108 citations

Purification and properties of heme-deficient hepatic soluble guanylate cyclase: Effects of heme and other factors on enzyme activation by NO, NO-heme, and protoporphyrin IX

1982 • 107 citations

Two dilatory mechanisms of anti-anginal drugs on epicardial coronary arteries in vivo: indirect, flow-dependent, endothelium-mediated dilation and direct smooth muscle relaxation.

1983 • 103 citations

Regulation of purified soluble guanylate cyclase by porphyrins and metalloporphyrins: a unifying concept.

1984 • 102 citations

Guanylate cyclase activation by nitroprusside and nitrosoguanidine is related to formation of S-nitrosothiol intermediates

1980 • 96 citations

Endothelium-Dependent Flow-Induced Dilation of Canine Femoral and Saphenous Arteries

1986 • 90 citations

S-Nitrosothiols and role of metal ions in decomposition to nitric oxide

1996 • 86 citations

Comparison of the inhibitory potencies of N(G)-methyl-, N(G)-nitro- and N(G)-amino-L-arginine on EDRF function in the rat: evidence for continuous basal EDRF release.

1991 • 84 citations

Activation of coronary arterial guanylate cyclase by nitric oxide, nitroprusside, and nitrosoguanidine—Inhibition by calcium, lanthanum, and other cations, enhancement by thiols

1980 • 65 citations

Vascular Smooth Muscle Relaxation by Nitro Compounds: Reduced Relaxation and cGMP Elevation in Tolerant Vessels and Reversal of Tolerance by Dithiothreitol

1982 • 63 citations

The separation of the heme and apoheme forms of soluble guanylate cyclase

1982 • 57 citations

Effects of Perfusion and Endothelium on the Reactivity of Isolated Resistance Arteries

1985 • 45 citations

Guanylate cyclase from bovine lung. Evidence that enzyme activation by phenylhydrazine is mediated by iron-phenyl hemoprotein complexes.

1984 • 45 citations

Methylene blue and ETYA block flow-dependent dilation in canine femoral artery

1986 • 43 citations

Nitric oxide regulates endothelium-dependent vasodilator responses in rabbit hindquarters vascular bed in vivo

1996 • 31 citations

Methemoglobin blockade of coronary arterial soluble guanylate cyclase activation by nitroso compounds and its reversal with dithiothreitol

1979 • 23 citations

Flow-Dependent Dilation in Myograph-Mounted Resistance Artery Segments

1988 • 13 citations