Cell Volume-Regulated Cation Channels

The Structure of the Potassium Channel: Molecular Basis of K ⁺ Conduction and Selectivity

1998 • 6,595 citations

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

2003 • 1,966 citations

Coassembly of KVLQT1 and minK (IsK) proteins to form cardiac IKS potassium channel

1996 • 1,741 citations

Vanilloid Receptor–Related Osmotically Activated Channel (VR-OAC), a Candidate Vertebrate Osmoreceptor

2000 • 1,348 citations

Epithelial sodium channels: function, structure, and regulation

1997 • 1,154 citations

Molecular characterization of the drosophila trp locus: A putative integral membrane protein required for phototransduction

1989 • 1,119 citations

Epithelial Sodium Channel/Degenerin Family of Ion Channels: A Variety of Functions for a Shared Structure

2002 • 1,007 citations

OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity

2000 • 982 citations

Calcium-activated potassium channels

1998 • 934 citations

The Polycystic Kidney Disease Proteins, Polycystin-1, Polycystin-2, Polaris, and Cystin, Are Co-Localized in Renal Cilia

2002 • 911 citations

Block of Stretch-Activated Ion Channels in Xenopus Oocytes by Gadolinium and Calcium Ions

1989 • 811 citations

Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain.

1989 • 765 citations

Abnormal osmotic regulation in trpv4 ^-/- mice

2003 • 760 citations

TRP channels: An overview

2005 • 721 citations

Normotonic cell shrinkage because of disordered volume regulation is an early prerequisite to apoptosis

2000 • 707 citations

Heat-evoked Activation of TRPV4 Channels in a HEK293 Cell Expression System and in Native Mouse Aorta Endothelial Cells

2002 • 659 citations

A possible unifying principle for mechanosensation

2005 • 657 citations

TRPC1 forms the stretch-activated cation channel in vertebrate cells

2005 • 640 citations

A Component of Calcium-activated Potassium Channels Encoded by the Drosophila slo Locus

1991 • 629 citations

A mammalian two pore domain mechano-gated S-like K+ channel

1998 • 627 citations

OSM-9, A Novel Protein with Structural Similarity to Channels, Is Required for Olfaction, Mechanosensation, and Olfactory Adaptation inCaenorhabditis elegans

1997 • 621 citations

A human intermediate conductance calcium-activated potassium channel

1997 • 601 citations

Molecular and functional properties of two-pore-domain potassium channels

2000 • 591 citations

Modulation of ION Channels by Protein Phosphorylation and Dephosphorylation

1994 • 530 citations

Receptor‐mediated control of regulatory volume decrease (RVD) and apoptotic volume decrease (AVD)

2001 • 523 citations

TRPV2 Is a Component of Osmotically Sensitive Cation Channels in Murine Aortic Myocytes

2003 • 481 citations

Combinatorial Expression of TRPV Channel Proteins Defines Their Sensory Functions and Subcellular Localization in C. elegans Neurons

2002 • 455 citations

A TRPV family ion channel required for hearing in Drosophila

2003 • 419 citations

KCNQ potassium channels: physiology, pathophysiology, and pharmacology

2001 • 417 citations

The FXYD Gene Family of Small Ion Transport Regulators or Channels: cDNA Sequence, Protein Signature Sequence, and Expression

2000 • 408 citations

Role of Ca²⁺-activated K⁺channels in human erythrocyte apoptosis

2003 • 384 citations

Impaired osmotic sensation in mice lacking TRPV4

2003 • 368 citations

TRAAK Is a Mammalian Neuronal Mechano-gated K+Channel

1999 • 367 citations

Molecular basis of fast inactivation in voltage and Ca ²⁺ -activated K ⁺ channels: A transmembrane β-subunit homolog

1999 • 362 citations

Cell volume regulation: osmolytes, osmolyte transport, and signal transduction

2003 • 362 citations

Molecular and Functional Characterization of the Melastatin-related Cation Channel TRPM3

2003 • 345 citations

Two Interdependent TRPV Channel Subunits, Inactive and Nanchung, Mediate Hearing inDrosophila

2004 • 342 citations

Potassium Channels in the Peripheral Microcirculation

2005 • 330 citations

Human TREK2, a 2P Domain Mechano-sensitive K+Channel with Multiple Regulations by Polyunsaturated Fatty Acids, Lysophospholipids, and Gs, Gi, and Gq Protein-coupled Receptors

2000 • 321 citations

The mechanosensitive nature of TRPV channels

2005 • 306 citations

Trp12, a novel Trp related protein from kidney

2000 • 303 citations

hKCNMB3 and hKCNMB4, cloning and characterization of two members of the large‐conductance calcium‐activated potassium channel β subunit family

2000 • 289 citations

Lipid and mechano-gated 2P domain K+ channels

2001 • 282 citations

Phospholemman (FXYD1) associates with Na,K-ATPase and regulates its transport properties

2002 • 273 citations

TREK-2, a New Member of the Mechanosensitive Tandem-pore K+ Channel Family

2000 • 263 citations

Purification and complete sequence determination of the major plasma membrane substrate for cAMP-dependent protein kinase and protein kinase C in myocardium

1991 • 257 citations

The MinK-related peptides

2004 • 250 citations

Activation of K⁺channels: an essential pathway in programmed cell death

2004 • 249 citations

Molecular cloning and characterization of two voltage‐gated K ⁺ channel cDNAs from human ventricle

1991 • 245 citations

TRP channels: a TR(I)P through a world of multifunctional cation channels

2005 • 241 citations

Inwardly Rectifying Potassium Channels: Their Molecular Heterogeneity and Function.

1997 • 236 citations

A phospholipid sensor controls mechanogating of the K+ channel TREK-1

2004 • 230 citations

Maxi-K_Ca, a Unique Member of the Voltage-Gated K Channel Superfamily

1998 • 220 citations

Mechanosensitive gating of atrial ATP-sensitive potassium channels.

1993 • 213 citations

Expression and Characterization of Human Transient Receptor Potential Melastatin 3 (hTRPM3)

2003 • 211 citations

Both membrane stretch and fatty acids directly activate large conductance Ca²⁺‐activated K⁺ channels in vascular smooth muscle cells

1992 • 204 citations

An intracellular proton sensor commands lipid- and mechano-gating of the K+ channel TREK-1

2002 • 201 citations

Purification and reconstitution of the high-conductance, calcium-activated potassium channel from tracheal smooth muscle.

1994 • 197 citations

Apoptosis, cell volume regulation and volume-regulatory chloride channels

2001 • 189 citations

Charybdotoxin inhibits proliferation and interleukin 2 production in human peripheral blood lymphocytes.

1989 • 182 citations

Tetraethylammonium block of Slowpoke calcium-activated potassium channels expressed in Xenopus oocytes: Evidence for tetrameric channel formation

1994 • 181 citations

Small conductance Ca²⁺‐activated K⁺ channels and calmodulin

2003 • 179 citations

Chloride conductance and volume-regulatory nonselective cation conductance in human red blood cell ghosts

2001 • 176 citations

Functional TRPV4 channels are expressed in human airway smooth muscle cells

2004 • 173 citations

Towards a structural view of gating in potassium channels

2004 • 169 citations

Modulation of the Two-pore Domain Acid-sensitive K+ Channel TASK-2 (KCNK5) by Changes in Cell Volume

2001 • 158 citations

Heterologous expression of specific K+ channels in T lymphocytes: functional consequences for volume regulation.

1993 • 155 citations

The 2P-domain K + channels: role in apoptosis and tumorigenesis

2004 • 149 citations

Phospholemman expression induces a hyperpolarization-activated chloride current in Xenopus oocytes.

1992 • 148 citations

Cell swelling activates K+ and Cl? channels as well as nonselective, stretch-activated cation channels in ehrlich ascites tumor cells

1992 • 145 citations

Unitary anion currents through phospholemman channel molecules

1995 • 142 citations

Regulation of Channels by the Serum and Glucocorticoid-Inducible Kinase - Implications for Transport, Excitability and Cell Proliferation

2003 • 139 citations

Apical maxi K channels in intercalated cells of CCT

1991 • 139 citations

Differential activation of the volume-sensitive cation channel TRP12 (OTRPC4) and volume-regulated anion currents in HEK-293 cells

2001 • 138 citations

The Ca2+-Activated K+ Channel of Intermediate Conductance:A Molecular Target for Novel Treatments?

2001 • 138 citations

Novel cation-selective mechanosensitive ion channel in the atrial cell membrane.

1993 • 136 citations

Blockers of volume-activated Cl? currents inhibit endothelial cell proliferation

1995 • 134 citations

Cross‐talk between the mechano‐gated K _2P channel TREK‐1 and the actin cytoskeleton

2005 • 131 citations

Blocking swelling‐activated chloride current inhibits mouse liver cell proliferation

2001 • 129 citations

FXYD Proteins: New Tissue-Specific Regulators of the Ubiquitous Na,K-ATPase

2003 • 126 citations

Electrostatic Tuning of Ion Conductance in Potassium Channels

2003 • 124 citations

Sequence-Function Analysis of the K+-Selective Family of Ion Channels Using a Comprehensive Alignment and the KcsA Channel Structure

2003 • 120 citations

A nonselective cation channel in rat liver cells is activated by membrane stretch

1990 • 117 citations

Membrane stretch: a physiological stimulator of Ca2+-activated K+ channels in thick ascending limb

1989 • 116 citations

Activity of ion channels during volume regulation by clonal N1E115 neuroblastoma cells.

1989 • 115 citations

Molecular and functional characterization of the small Ca2+-regulated K+ channel (rSK4) of colonic crypts

1999 • 112 citations

The epithelial sodium channel: from molecule to disease

2004 • 110 citations

Toward Linking Structure With Function in ATP-Sensitive K+ Channels

2004 • 109 citations

Maxi K⁺ channel mediates regulatory volume decrease response in a human bronchial epithelial cell line

2002 • 108 citations

Comparison of basal gene expression profiles and effects of hepatocarcinogens on gene expression in cultured primary human hepatocytes and HepG2 cells

2004 • 107 citations

Large-Conductance, Ca2+-Activated K+ Channels: Function, Pharmacology and Drugs

2002 • 105 citations

Volume dynamics in migrating epithelial cells measured with atomic force microscopy

1999 • 102 citations

A calcium-permeable stretch-activated cation channel in renal proximal tubule

1991 • 99 citations

The Shrinkage-activated Na<sup>+</sup> Conductance of Rat Hepatocytes and its Possible Correlation to rENaC

2000 • 98 citations

Migration of transformed renal epithelial cells is regulated by K + channel modulation of actin cytoskeleton and cell volume

1999 • 96 citations

Mechanically gated channel activity in cytoskeleton‐deficient plasma membrane blebs and vesicles from Xenopus oocytes

2000 • 95 citations

Protein kinase C and cyclic AMP-dependent protein kinase phosphorylate phospholemman, an insulin and adrenaline-regulated membrane phosphoprotein, at specific sites in the carboxy terminal domain

1994 • 93 citations

Characterization of the Selectivity Filter of the Epithelial Sodium Channel

2000 • 90 citations

IK channels are involved in the regulatory volume decrease in human epithelial cells

2003 • 87 citations

Selective response of human airway epithelia to luminal but not serosal solution hypertonicity. Possible role for proximal airway epithelia as an osmolality transducer.

1994 • 85 citations

KCNQ1 Channels Sense Small Changes in Cell Volume

2003 • 85 citations

Stretch‐activated non‐selective cation channels in the antiluminal membrane of porcine cerebral capillaries.

1992 • 84 citations

Cell Volume Regulation in Liver

1988 • 83 citations

Hypertonic stress increases the Na+ conductance of rat hepatocytes in primary culture.

1995 • 83 citations

Regulation of the Epithelial Na+ Channel by Membrane Tension

1998 • 83 citations

Cell volume and the regulation of apoptotic cell death

2004 • 80 citations

Modulation of Small Conductance Calcium-Activated Potassium (SK) Channels: A New Challenge in Medicinal Chemistry

2003 • 80 citations

The stimulation of Na,K,Cl cotransport and of system A for neutral amino acid transport is a mechanism for cell volume increase during the cell cycle

1996 • 77 citations

Phospholemman modulates Na⁺/Ca²⁺exchange in adult rat cardiac myocytes

2003 • 74 citations

Swelling-activated Gd3+-sensitive Cation Current and Cell Volume Regulation in Rabbit Ventricular Myocytes

1997 • 73 citations

Hypertonicity activates nonselective cation channels in mouse cortical collecting duct cells.

1995 • 69 citations

Chloride-Dependent Cation Conductance Activated During Cellular Shrinkage

1992 • 65 citations

The KCNQ5 potassium channel from mouse: A broadly expressed M-current like potassium channel modulated by zinc, pH, and volume changes

2005 • 65 citations

Effects of anions on cellular volume and transepithelial Na+ transport across toad urinary bladder

1985 • 65 citations

Cytoskeleton and ion movements during volume regulation in cultured PC12 cells

1993 • 64 citations

A study of stretch‐activated channels in the membrane of frog oocytes: interactions with Ca2+ ions.

1988 • 63 citations

Contribution of the IsK (MinK) Potassium Channel Subunit to Regulatory Volume Decrease in Murine Tracheal Epithelial Cells

2000 • 63 citations

Role of Na⁺ conductance, Na⁺‐H⁺ exchange, and Na⁺‐K⁺‐2Cl⁻ symport in the regulatory volume increase of rat hepatocytes

1998 • 61 citations

Inhibition of ion conductances by osmotic shrinkage of Madin-Darby canine kidney cells

1991 • 61 citations

Anion, cation, and zwitterion selectivity of phospholemman channel molecules

1997 • 58 citations

Identification of an Endogenous Inhibitor of the Cardiac Na+/Ca2+ Exchanger, Phospholemman

2005 • 56 citations

Osmotic Shrinkage Activates Nonselective Cation (NSC) Channels in Various Cell Types

1999 • 55 citations

Influence of cloned voltage-gated K+ channel expression on alanine transport, Rb+ uptake, and cell volume

1993 • 53 citations

Effect of volume changes on a potassium current in rabbit corneal epithelial cells

1993 • 52 citations

Volume regulation in a toad epithelial cell line: role of coactivation of K+ and Cl‐ channels.

1995 • 52 citations

Calcium-dependent regulation of secretion in biliary epithelial cells: The role of apamin-sensitive SK channels

2004 • 51 citations

Hyposmotic activation of Ca-activated K channels in cultured rabbit kidney proximal tubule cells

1991 • 50 citations

Eicosanoids modulate apical Ca(2+)-dependent K+ channels in cultured rabbit principal cells

1992 • 49 citations

Hypotonic shock activates a maxi K+ channel in primary cultured proximal tubule cells

1990 • 48 citations

Ca2+-activated K+ channels are involved in regulatory volume decrease in acinar cells isolated from the rat lacrimal gland

1994 • 48 citations

A Novel K _ATP Current in Cultured Neonatal Rat Atrial Appendage Cardiomyocytes

1999 • 47 citations

Reduction of phospholemman expression decreases osmosensitive taurine efflux in astrocytes

2001 • 46 citations

Hypertonic activation of a non‐selective cation conductance in HeLa cells and its contribution to cell volume regulation

2003 • 46 citations

Regulation of K+ Flow by a Ring of Negative Charges in the Outer Pore of BKCa Channels. Part I

2004 • 45 citations

Hypotonic solution increases the slowly activating potassium current IsK expressed in Xenopus oocytes

1992 • 45 citations

Activation of a nonselective cation channel by swelling in atrial cells

1993 • 44 citations

Mechanosensitive Calcium Entry and Mobilization in Renal A6 Cells

1999 • 42 citations

Volume sensitive efflux of taurine in HEK293 cells overexpressing phospholemman

2000 • 41 citations

K+ conductance activated during regulatory volume decrease. The channels in Ehrlich cells and their possible molecular counterpart

2001 • 41 citations

The Effects of Putative K+ Channel Blockers on Volume Regulation of Murine Spermatozoa1

2005 • 40 citations

Hypo-osmotic challenge stimulates transepithelial k+ secretion and activates apical i sK channel in vestibular dark cells

1995 • 40 citations

Potential contribution of epithelial Na+ channel to net secretion of aqueous humor

1997 • 40 citations

Effect of basolateral or apical hyposmolarity on apical maxi K channels of everted rat collecting tubule

1995 • 39 citations

Feeling the pressure in mammalian somatosensation

2005 • 38 citations

Molecular characterization of volume-sensitive SK_Cachannels in human liver cell lines

2002 • 37 citations

Modulation of Xenopus oocyte-expressed phospholemman-induced ion currents by co-expression of protein kinases

1999 • 36 citations

Cell volume-sensitive sodium channels upregulated by glucocorticoids in U937 macrophages

2000 • 35 citations

Membrane crosstalk in the mammalian proximal tubule during alterations in transepithelial sodium transport

1990 • 34 citations

Role of tyrosine kinase activity in cardiac slow delayed rectifier channel modulation by cell swelling

1997 • 33 citations

Spontaneously oscillating K+ channel activity in transformed Madin-Darby canine kidney cells.

1993 • 33 citations

Modulation of the volume-sensitive K + current in Ehrlich ascites tumour cells by pH

2001 • 33 citations

Ionic basis for membrane potential changes induced by hypoosmotic stress in guinea-pig ventricular myocytes

2001 • 32 citations

Increases in Intracellular pH and Ca 2+ are Essential for K + Channel Activation After Modest `Physiological' Swelling in Villus Epithelial Cells

1999 • 31 citations

Ca2+ release and activation of K+ and Cl- currents by extracellular ATP in distal nephron epithelial cells

1995 • 31 citations

Structural Basis of Inward Rectifying Potassium Channel Gating

2002 • 31 citations

Phospholemman: A Cardiac Taurine Channel Involved in Regulation of Cell Volume

1998 • 29 citations

Kir6.2-deficient mice are susceptible to stimulated ANP secretion: K channel acts as a negative feedback mechanism?

2005 • 29 citations

Osmolyte and Na+ transport balances of rat hepatocytes as a function of hypertonic stress

2000 • 28 citations

The epithelial Na⁺ channel (ENaC) is related to the hypertonicity‐induced Na⁺ conductance in rat hepatocytes

2001 • 28 citations

Partial apamin sensitivity of human small conductance Ca 2+ -activated K + channels stably expressed in Chinese hamster ovary cells

2002 • 28 citations

Molecular BKology: The Study of Splicing and Dicing

2002 • 27 citations

Effects of Phospholemman Expression on Swelling-Activated Ion Currents and Volume Regulation in Embryonic Kidney Cells

2003 • 26 citations

Volume-sensitive Tyrosine Kinases Regulate Liver Cell Volume through Effects on Vesicular Trafficking and Membrane Na+ Permeability

2003 • 25 citations

Steroids and Exogenous γ-ENaC Subunit Modulate Cation Channels Formed by α-ENaC in Human B Lymphocytes

2004 • 25 citations

Effects of hyperosmotic medium on hepatocyte volume, transmembrane potential and intracellular K+ activity

1991 • 25 citations

Hypotonic-induced stretch counteracts the efficacy of the class III antiarrhythmic agent E-4031 in guinea pig myocytes

1996 • 25 citations

Plasticity of renal epithelial cells: the way a potassium channel supports migration.

1996 • 25 citations

In rat hepatocytes, the hypertonic activation of Na⁺ conductance and Na⁺‐K⁺‐2Cl⁻ symport ‐ but not Na⁺‐H⁺ antiport ‐ is mediated by protein kinase C

2001 • 25 citations

Activation of Na+/H(+)-exchanger by transforming Ha-ras requires stimulated cellular calcium influx and is associated with rearrangement of the actin cytoskeleton.

1997 • 24 citations

Shrinkage activates a nonselective conductance: involvement of a Walker-motif protein and PKC

1996 • 24 citations

Molecular mechanisms of regulation of fast‐inactivating voltage‐dependent transient outward K⁺ current in mouse heart by cell volume changes

2005 • 23 citations

Volume-activated, gadolinium-sensitive whole-cell currents in single proximal cells of frog kidney

1994 • 22 citations

Ionic mechanisms of regulatory volume increase (RVI) in the human hepatoma cell-line HepG2

2002 • 22 citations

Role of KCNQ1 in the Cell Swelling-Induced Enhancement of the Slowly Activating Delayed Rectifier K+ Current.

2002 • 21 citations

Hypertonic cell shrinkage reduces the K + conductance of rat colonic crypts

1998 • 21 citations

Mechanism of Shrinkage Activation of Nonselective Cation Channels in M-1 Mouse Cortical Collecting Duct Cells

2000 • 21 citations

Effects of hypertonia on voltage-gated ion currents in freshly isolated hippocampal neurons, and on synaptic currents in neurons in hippocampal slices

1997 • 20 citations

A cell shrinkage‐induced non‐selective cation conductance with a novel pharmacology in Ehrlich–Lettre‐ascites tumour cells

2003 • 19 citations

Effects of cell volume changes on membrane ionic permeabilities and sodium transport in frog skin (Rana ridibunda).

1987 • 19 citations

Hypertonicity Decreases Basolateral K + and Cl − Conductances in Rabbit Proximal Convoluted Tubule

1997 • 18 citations

Regulation of Ion Channels in the Cortical Collecting Duct

1993 • 18 citations

Membrane currents controlled by physical forces in cultured mesangial cells

1993 • 16 citations

Hypotonically Induced Whole-Cell Currents in A6 Cells: Relationship with Cell Volume and Cytoplasmic Ca2+.

1997 • 16 citations

Ion selectivity of volume regulatory mechanisms present during a hypoosmotic challenge in vestibular dark cells

1995 • 16 citations

Apical Na+ permeability of frog skin during serosal Cl− replacement

1988 • 14 citations

Two Types of Stretch-Activated Channel Activities in Guinea-Pig Gastric Smooth Muscle Cells.

1996 • 14 citations

An amiloride-sensitive, volume-dependent Na+ transport across the lamprey (Lampetra fluviatilis) erythrocyte membrane.

1996 • 14 citations

A new technique for evaluating volume sensitivity of ion channels

1996 • 13 citations

Existence, properties, and functional expression of “Maxi-K”-type, Ca2+-activated K+ channels in short-term cultured hepatocytes

1997 • 13 citations

Increment of calcium-activated and delayed rectifier potassium current by hyposmotic swelling in gastric antral circular myocytes of guinea pig.

2001 • 12 citations

A novel hypertonicity‐induced cation channel in primary cultures of human hepatocytes

2005 • 11 citations

Osmosensitive properties of rapid and slow delayed rectifier K⁺ currents in guinea‐pig heart cells

2003 • 9 citations

A K+-selective channel in the colonic carcinoma cell line: CaCo-2 is activated with membrane stretch

1991 • 8 citations

Effects of serosal anion composition on the permeability properties of rabbit urinary bladder

1989 • 7 citations

Hypertonicity-Induced Cation Channels in Rat Hepatocytes and Their Intracellular Regulation

2006 • 7 citations

Cell Shrinkage Activates a Cation Conductance in Principal Cells of Rat Cortical Collecting Duct

1997 • 7 citations

Hypertonic activation of phospholemman in solitary rat hepatocytes in primary culture

2003 • 7 citations

Ca(2+)-dependent K+ channels in the cortical collecting duct of rat.

1997 • 7 citations

Mechanosensitive Nonselective Cation Channels in the Antiluminal Membrane of Cerebral Capillaries (Blood-Brain Barrier)

1993 • 4 citations

Effect of actin microfilament on potassium current in guinea pig gastric myocytes

2004 • 3 citations