A phospholipid sensor controls mechanogating of the K+ channel TREK-1

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition

2001 • 1,240 citations

Molecular Basis of Mechanotransduction in Living Cells

2001 • 1,102 citations

Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gβγ

1998 • 886 citations

Inhalational anesthetics activate two-pore-domain background K+ channels

1999 • 637 citations

A mammalian two pore domain mechano-gated S-like K+ channel

1998 • 627 citations

Molecular and functional properties of two-pore-domain potassium channels

2000 • 591 citations

Membrane Phospholipid Control of Nucleotide Sensitivity of K _ATP Channels

1998 • 569 citations

CNS Distribution of Members of the Two-Pore-Domain (KCNK) Potassium Channel Family

2001 • 547 citations

PIP ₂ and PIP as Determinants for ATP Inhibition of K _ATP Channels

1998 • 517 citations

PIP2 Activates KCNQ Channels, and Its Hydrolysis Underlies Receptor-Mediated Inhibition of M Currents

2003 • 511 citations

The TRPM7 channel is inactivated by PIP2 hydrolysis

2002 • 509 citations

TREK-1, a K+ channel involved in neuroprotection and general anesthesia

2004 • 505 citations

Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel.

1996 • 483 citations

TREK-1 is a heat-activated background K+ channel

2000 • 481 citations

Recovery from Muscarinic Modulation of M Current Channels Requires Phosphatidylinositol 4,5-Bisphosphate Synthesis

2002 • 479 citations

The Complex and Intriguing Lives of PIP2 with Ion Channels and Transporters

2001 • 466 citations

A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids

1998 • 453 citations

Properties and modulation of mammalian 2P domain K+ channels

2001 • 442 citations

Mechano- or Acid Stimulation, Two Interactive Modes of Activation of the TREK-1 Potassium Channel

1999 • 404 citations

Alterations in Conserved Kir Channel-PIP2 Interactions Underlie Channelopathies

2002 • 388 citations

Lysophospholipids Open the Two-pore Domain Mechano-gated K+ Channels TREK-1 and TRAAK

2000 • 372 citations

Human TREK2, a 2P Domain Mechano-sensitive K+Channel with Multiple Regulations by Polyunsaturated Fatty Acids, Lysophospholipids, and Gs, Gi, and Gq Protein-coupled Receptors

2000 • 321 citations

Functional Conversion Between A-Type and Delayed Rectifier K ⁺ Channels by Membrane Lipids

2004 • 315 citations

Tarantula peptide inhibits atrial fibrillation

2001 • 304 citations

Lipid and mechano-gated 2P domain K+ channels

2001 • 282 citations

Bilayer-dependent inhibition of mechanosensitive channels by neuroactive peptide enantiomers

2004 • 278 citations

TREK-2, a New Member of the Mechanosensitive Tandem-pore K+ Channel Family

2000 • 263 citations

Mechanosensitive ion channels in nonspecialized cells

2005 • 254 citations

Formation of Functional Heterodimers between the TASK-1 and TASK-3 Two-pore Domain Potassium Channel Subunits

2002 • 253 citations

The neuroprotective agent riluzole activates the two P domain K(+) channels TREK-1 and TRAAK.

2000 • 242 citations

Receptor-mediated hydrolysis of plasma membrane messenger PIP2 leads to K+-current desensitization

2000 • 228 citations

Phosphatidylinositol-4,5-bisphosphate, PIP2, controls KCNQ1/KCNE1 voltage-gated potassium channels: a functional homology between voltage-gated and inward rectifier K+ channels

2003 • 221 citations

An intracellular proton sensor commands lipid- and mechano-gating of the K+ channel TREK-1

2002 • 201 citations

Motoneurons Express Heteromeric TWIK-Related Acid-Sensitive K⁺(TASK) Channels Containing TASK-1 (KCNK3) and TASK-3 (KCNK9) Subunits

2004 • 199 citations

K+-dependent Cerebellar Granule Neuron Apoptosis

2003 • 187 citations

Mechanisms underlying excitatory effects of group I metabotropic glutamate receptors via inhibition of 2P domain K+ channels

2003 • 185 citations

Dimerization of TWIK-1 K+ channel subunits via a disulfide bridge.

1996 • 170 citations

KCNK2: reversible conversion of a hippocampal potassium leak into a voltage-dependent channel

2001 • 165 citations

Two-Pore-Domain (Kcnk) Potassium Channels: Dynamic Roles in Neuronal Function

2003 • 150 citations

Functional expression of TASK‐1/TASK‐3 heteromers in cerebellar granule cells

2003 • 135 citations

Fatty acid-sensitive two-pore domain K+ channels

2003 • 118 citations

Inhibition of TASK-1 potassium channel by phospholipase C

2001 • 105 citations

Anesthetic-sensitive 2P Domain K+Channels

2001 • 103 citations

Molecular Basis of the Voltage-Dependent Gating of TREK-1, a Mechano-Sensitive K+ Channel

2002 • 89 citations

TRPs Make Sense

2003 • 85 citations

Update on Tandem Pore (2P) Domain K+ Channels

2003 • 38 citations

Gβγ and K _ACh : Old Story, New Insights

2003 • 17 citations

Ras signaling pathway for analysis of protein-protein interactions

2001 • 14 citations