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Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor

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Apoptosis of T cells mediated by galectin-1

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Introduction to galectins

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Galectins and their ligands: amplifiers, silencers or tuners of the inflammatory response?

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Targeted inhibition of galectin-1 gene expression in tumor cells results in heightened T cell-mediated rejection

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Signal transduction by the TCR for antigen

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Expression and function of galectin-3, a beta-galactoside-binding lectin, in human monocytes and macrophages.

1995 • 392 citations

Recombinant Galectin-1 and Its Genetic Delivery Suppress Collagen-Induced Arthritis via T Cell Apoptosis

1999 • 358 citations

Restricted Receptor Segregation into Membrane Microdomains Occurs on Human T Cells During Apoptosis Induced by Galectin-1

1999 • 351 citations

God must love galectins; He made so many of them

1999 • 321 citations

TRANSCRIPTIONAL REGULATION OF T LYMPHOCYTE DEVELOPMENT AND FUNCTION

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Developmental regulation, expression, and apoptotic potential of galectin-9, a beta-galactoside binding lectin.

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Regulation of Fas-Ligand Expression during Activation-induced Cell Death in T Lymphocytes via Nuclear Factor κB

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Galectin-1 suppresses experimental colitis in mice

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β-Galactoside-binding protein secreted by activated T cells inhibits antigen-induced proliferation of T cells

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Role of galectins in inflammatory and immunomodulatory processes

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Ah, sweet mystery of death! Galectins and control of cell fate

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Specific inhibition of T‐cell adhesion to extracellular matrix and proinflammatory cytokine secretion by human recombinant galectin‐1

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Galectin-1 Induces Partial TCR ζ-Chain Phosphorylation and Antagonizes Processive TCR Signal Transduction

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Galectins: A New Family of Regulators of Inflammation

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Expression of galectins in cancer: A critical review

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Dimeric Galectin-1 Induces Surface Exposure of Phosphatidylserine and Phagocytic Recognition of Leukocytes without Inducing Apoptosis

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Inhibition of T Cell Activation by Pharmacologic Disruption of the MEK1/ERK MAP Kinase or Calcineurin Signaling Pathways Results in Differential Modulation of Cytokine Production

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Activated Rat Macrophages Produce a Galectin-1-Like Protein That Induces Apoptosis of T Cells: Biochemical and Functional Characterization

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Galectin-1 exerts immunomodulatory and protective effects on concanavalin a-induced hepatitis in mice

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Stat5 Activation Is Uniquely Associated with Cytokine Signaling in Peripheral T Cells

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Molecular mechanisms implicated in galectin-1-induced apoptosis: activation of the AP-1 transcription factor and downregulation of Bcl-2

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Expression of the L14 lectin during mouse embryogenesis suggests multiple roles during pre- and post-implantation development

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Galectin-3 Mediates IL-4-Induced Survival and Differentiation of B Cells: Functional Cross-Talk and Implications during Trypanosoma cruzi Infection

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Opposite effects of galectin-1 on alternative metabolic pathways of L-arginine in resident, inflammatory, and activated macrophages

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Synthesis of an endogeneous lectin, galectin-1, by human endothelial cells is up-regulated by endothelial cell activation

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Induction of allogenic T-cell hyporesponsiveness by galectin-1-mediated apoptotic and non-apoptotic mechanisms

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Differential T-Cell Antigen Receptor Signaling Mediated by the Src Family Kinases Lck and Fyn

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Involvement of CD2 and CD3 in galectin-1 induced signaling in human Jurkat T-cells

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Galectin genes: Regulation of expression

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Shedding light on the immunomodulatory properties of galectins: Novel regulators of innate and adaptive immune responses

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Regulated Expression and Effect of Galectin-1 onTrypanosoma cruzi-Infected Macrophages: Modulation of Microbicidal Activity and Survival

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Activation-induced expression of MICA on T lymphocytes involves engagement of CD3 and CD28

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Regulated expression of a 16-kd galectin-like protein in activated rat macrophages

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Expression of galectins-1 and -3 correlates with defective mononuclear cell apoptosis in patients with juvenile idiopathic arthritis.

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Regulation of CD45-induced signaling by galectin-1 in Burkitt lymphoma B cells

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Galectin-1 Is Overexpressed in Nasal Polyps under Budesonide and Inhibits Eosinophil Migration

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Progress in deciphering the information content of the 'glycome'--a crescendo in the closing years of the millennium.

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T cell activation signals up-regulate p38 mitogen-activated protein kinase activity and induce TNF-alpha production in a manner distinct from LPS activation of monocytes.

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Galectin-3 expression in macrophages is signaled by Ras/MAP kinase pathway and up-regulated by modified lipoproteins

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Biological Activities of Ecalectin: A Novel Eosinophil-Activating Factor

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Cell-Specific Transcriptional Regulation and Reactivation of Galectin-1 Gene Expression Are Controlled by DNA Methylation of the Promoter Region

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Potential roles of galectins in myeloid differentiation into three different lineages

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Role of mitogen‐activated protein kinases in activation‐induced apoptosis of T cells

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The sugar code in drug delivery

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