Expression of galectins in cancer: A critical review

Apoptosis of T cells mediated by galectin-1

1995 • 1,056 citations

Mac-2, a novel 32,000 Mr mouse macrophage subpopulation-specific antigen defined by monoclonal antibodies.

1982 • 428 citations

Application of an immunodiagnostic method for improving preoperative diagnosis of nodular thyroid lesions

2001 • 417 citations

Identification of galectin-3 as a factor in pre-mRNA splicing.

1995 • 397 citations

Differential expression of galectin-1 and galectin-3 in thyroid tumors. Potential diagnostic implications.

1995 • 332 citations

Expression Profiling of Renal Epithelial Neoplasms

2001 • 316 citations

Endogenous lectins from cultured cells: nuclear localization of carbohydrate-binding protein 35 in proliferating 3T3 fibroblasts.

1987 • 242 citations

Decreased expression of Mac-2 (carbohydrate binding protein 35) and loss of its nuclear localization are associated with the neoplastic progression of colon carcinoma.

1993 • 236 citations

Characterization of Gene Expression Profiles in Intraductal Papillary-Mucinous Tumors of the Pancreas

2002 • 228 citations

Differential expression of galectin 3 and galectin 1 in colorectal cancer progression

1997 • 216 citations

Galectin-3 is a presurgical marker of human thyroid carcinoma.

1998 • 215 citations

DECREASED EXPRESSION OF GALECTIN-3 IS ASSOCIATED WITH PROGRESSION OF HUMAN BREAST CANCER

1996 • 212 citations

Expression of galectin-3 in fine-needle aspirates as a diagnostic marker differentiating benign from malignant thyroid neoplasms

1999 • 178 citations

Expression of an endogenous galactose-binding lectin correlates with neoplastic progression in the colon

1995 • 175 citations

Expression of the endogenous galactose-binding protein galectin-3 correlates with the malignant potential of tumors in the central nervous system

1997 • 163 citations

Expression of cytoplasmic galectin-3 as a prognostic marker in tongue carcinoma.

2000 • 162 citations

Galectin-1 is highly expressed in human gliomas with relevance for modulation of invasion of tumor astrocytes into the brain parenchyma

2001 • 159 citations

Surface expression of functional IgE binding protein, an endogenous lectin, on mast cells and macrophages.

1992 • 156 citations

Expression of the 67-kD laminin receptor, galectin-1, and galectin-3 in advanced human uterine adenocarcinoma

1996 • 155 citations

Immunohistochemical Expression of Galectin-3 in Benign and Malignant Thyroid Lesions

2002 • 155 citations

Galectin-3 and CD44v6 Isoforms in the Preoperative Evaluation of Thyroid Nodules

1999 • 152 citations

Increased content of an endogenous lactose-binding lectin in human colorectal carcinoma progressed to metastatic stages.

1991 • 152 citations

GALECTIN-3 AND LAMININ EXPRESSION IN NEOPLASTIC AND NON-NEOPLASTIC THYROID TISSUE

1997 • 150 citations

Expression of a 31‐kDa lactoside‐binding lectin in normal human gastric Mucosa and in primary and metastatic gastric carcinomas

1994 • 139 citations

Galectin-3 as a Presurgical Immunocytodiagnostic Marker of Minimally Invasive Follicular Thyroid Carcinoma

2001 • 135 citations

Distinction Between Papillary Thyroid Hyperplasia and Papillary Thyroid Carcinoma by Immunohistochemical Staining for Cytokeratin 19, Galectin-3, and HBME-1

2003 • 134 citations

Comparative Analysis of Galectins in Primary Tumors and Tumor Metastasis in Human Pancreatic Cancer

2001 • 130 citations

Galectin-3 expression in various thyroid neoplasms and its possible role in metastasis formation

2000 • 128 citations

Increased expression of galectin-1 in carcinoma-associated stroma predicts poor outcome in prostate carcinoma patients

2001 • 125 citations

Carbohydrate-binding Protein 35

1989 • 125 citations

Alteration of the cytoplasmic/nuclear expression pattern of galectin‐3 correlates with prostate carcinoma progression

2000 • 116 citations

Endogenous lectins from cultured cells: subcellular localization of carbohydrate-binding protein 35 in 3T3 fibroblasts.

1986 • 114 citations

Differential expression of the 67-kD laminin receptor and 31-kD human laminin-binding protein in human ovarian carcinomas

1994 • 112 citations

Decreased galectin-3 expression in prostate cancer

2000 • 111 citations

Involvement of galectin-3 expression in colorectal cancer progression and metastasis.

1999 • 109 citations

Transformation‐related changes in the expression of endogenous cell lectins

1987 • 109 citations

Cytokeratin 19 and Galectin 3 Immunohistochemistry in the Differential Diagnosis of Solitary Thyroid Nodules

2017 • 107 citations

Identification of carbohydrate binding protein 35 in heterogeneous nuclear ribonucleoprotein complex

1988 • 106 citations

Immunohistochemical localization of galectin-3 in malignant and benign human thyroid tissue.

1998 • 101 citations

Expression of galectin-1 mRNA correlates with the malignant potential of human gliomas and expression of antisense galectin-1 inhibits the growth of 9 glioma cells

2000 • 101 citations

Galectin-3 Messenger Ribonucleic Acid and Protein Are Expressed in Benign Thyroid Tumors

2002 • 100 citations

Carbohydrate-binding protein 35. I. Properties of the recombinant polypeptide and the individuality of the domains

1993 • 98 citations

Galectin-1 and galectin-3 expression in human bladder transitional-cell carcinomas

1999 • 98 citations

The levels of expression of galectin-1, galectin-3, and the Thomsen-Friedenreich antigen and their binding sites decrease as clinical aggressiveness increases in head and neck cancers

1999 • 98 citations

Expression of galectins in head and neck squamous cell carcinoma

1996 • 94 citations

Inverse Modulation of Steady-State Messenger RNA Levels of Two Non-Integrin Laminin-Binding Proteins in Human Colon Carcinoma

1992 • 94 citations

Localization of endogenous lectins in normal human breast, benign breast lesions and mammary carcinomas

1986 • 94 citations

Galectin-1 expression in prostate tumor-associated capillary endothelial cells is increased by prostate carcinoma cells and modulates heterotypic cell-cell adhesion.

1999 • 91 citations

Galectin-3, a marker of well-differentiated thyroid carcinoma, is expressed in thyroid nodules with cytological atypia

2002 • 88 citations

Galectin-3 Is a Nuclear Matrix Protein Which Binds RNA

1995 • 85 citations

Carbohydrate-binding protein 35. Isoelectric points of the polypeptide and a phosphorylated derivative.

1990 • 79 citations

Expression of endogenous galectin-1 and galectin-3 in intrahepatic cholangiocarcinoma

2001 • 78 citations

Galectin-3 Is Not an Universal Marker of Malignancy in Thyroid Nodular Disease in Children and Adolescents

2002 • 76 citations

Increased Galectin-3 Expression in Gastric Cancer: Correlations with Histopathological Subtypes, Galactosylated Antigens and Tumor Cell Proliferation

2000 • 69 citations

Expression of galectin‐1 in normal human thyroid gland and in differentiated and poorly differentiated thyroid tumors

1995 • 69 citations

Galectin-3 Expression in Hyalinizing Trabecular Tumors of the Thyroid Gland

2003 • 64 citations

Galectin‐3 and galectin‐3‐binding site expression in human adult astrocytic tumours and related angiogenesis

1999 • 63 citations

Increased expression of the negative growth factor, galactoside-binding protein, gene in transformed thyroid cells and in human thyroid carcinomas.

1992 • 62 citations

Lactose-binding lectin expression in human colorectal carcinomas. Relation to tumor progression

1991 • 61 citations

Galectin-1 and galectin-3 expression in human prostate tissue and prostate cancer

1999 • 60 citations

Differential Reactivity for Galectin-3 in Hürthle Cell Adenomas and Carcinomas

2001 • 56 citations

Expression of two different endogenous galactoside-binding lectins sharing sequence homology.

1988 • 55 citations

Role of galectin-3 immunodetection in the cytological diagnosis of thyroid cystic papillary carcinoma

2002 • 54 citations

Role of galaptin in ovarian carcinoma adhesion to extracellular matrix in vitro

1990 • 52 citations

Diagnostic utility of galectin‐3 and CD26/DPPIV as preoperative diagnostic markers for thyroid nodules

2002 • 52 citations

Determination of Galectin-3 Messenger Ribonucleic Acid Overexpression in Papillary Thyroid Cancer by Quantitative Reverse Transcription-Polymerase Chain Reaction

2002 • 49 citations

Galectin‐3 and carcinoembryonic antigen expression in medullary thyroid carcinoma: possible relation to tumour progression

2000 • 46 citations

The Meanings of Markers: Ancillary Techniques in Diagnosis of Thyroid Neoplasia

2002 • 44 citations

Differential expression of galectin-1 and galectin-3 in benign and malignant salivary gland neoplasms.

2000 • 37 citations

Localization of galectin-3 in normal and diseased pancreatic tissue

1998 • 37 citations

Expression of ɛBP, a β‐galactoside‐binding soluble lectin, in normal and neoplastic epidermis

1994 • 36 citations

Localization of Endogenous β-Galactoside-Binding Lectin in Human Cells and Tissues

1991 • 34 citations

Differential expression of galectin‐3 in medullary thyroid carcinoma and C‐cell hyperplasia

2002 • 32 citations

Cloning and expression of cDNA for two endogenous UV-2237 fibrosarcoma lectin genes

1987 • 29 citations

Decreased expression of galectin-3 in basal cell carcinoma of the skin.

1999 • 22 citations

Untersuchungen zur Expression von Galectin-3 im Schilddrüsengewebe und in Follikelzelltumoren der Schilddrüse

2001 • 14 citations

[Expression of TTF-1 in thyroid tumors originating from follicular epithelium and its correlation with expression of RET, galectin-3 and mucin-1 genes].

2002 • 5 citations