Growth factors as transforming proteins

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Angiogenic Factors

1987 • 3,702 citations

PROTEIN-TYROSINE KINASES

1985 • 2,198 citations

Interleukin-2: Inception, Impact, and Implications

1988 • 2,166 citations

Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin

1986 • 2,137 citations

The biology of platelet-derived growth factor

1986 • 2,036 citations

GROWTH FACTOR RECEPTOR TYROSINE KINASES

1988 • 1,841 citations

The Human Hematopoietic Colony-Stimulating Factors

1987 • 1,728 citations

Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas

1988 • 1,698 citations

Autocrine growth factors and cancer

1985 • 1,462 citations

Growth factors from murine sarcoma virus-transformed cells.

1978 • 1,457 citations

Autocrine Secretion and Malignant Transformation of Cells

1980 • 1,370 citations

Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancer

1985 • 1,360 citations

Some recent advances in the chemistry and biology of transforming growth factor-beta.

1987 • 1,308 citations

Peptide Growth Factors and Their Receptors

1991 • 1,221 citations

Actions of Insulin-Like Growth Factors

1985 • 1,141 citations

Isolation and characterization of genomic and cDNA clones of human erythropoietin

1985 • 1,101 citations

Endothelial cell-derived basic fibroblast growth factor: synthesis and deposition into subendothelial extracellular matrix.

1987 • 1,045 citations

The Granulocyte-Macrophage Colony-Stimulating Factors

1985 • 1,007 citations

Molecular cloning of gene sequences regulated by platelet-derived growth factor

1983 • 989 citations

Synthesis of messenger RNAs for transforming growth factors alpha and beta and the epidermal growth factor receptor by human tumors.

1987 • 895 citations

Transforming growth factors produced by certain human tumor cells: polypeptides that interact with epidermal growth factor receptors.

1980 • 892 citations

Human transforming growth factor-α: Precursor structure and expression in E. coli

1984 • 888 citations

Production and auto-induction of transforming growth factor-α in human keratinocytes

1987 • 870 citations

Purification and NH2-terminal amino acid sequence of a T-cell-derived lymphokine with growth factor activity for B-cell hybridomas.

1986 • 701 citations

Human Endothelial Cell Growth Factor: Cloning, Nucleotide Sequence, and Chromosome Localization

1986 • 679 citations

Autocrine activities of basic fibroblast growth factor: regulation of endothelial cell movement, plasminogen activator synthesis, and DNA synthesis.

1988 • 647 citations

Transforming growth factor beta 1 positively regulates its own expression in normal and transformed cells.

1988 • 604 citations

Human basic fibroblast growth factor: nucleotide sequence and genomic organization.

1986 • 604 citations

Two Classes of PDGF Receptor Eecognize Different Isoforms of PDGF

1988 • 603 citations

Complexity of the early genetic response to growth factors in mouse fibroblasts.

1988 • 579 citations

Induction of β2-interferon by tumor necrosis factor: A homeostatic mechanism in the control of cell proliferation

1986 • 577 citations

Interleukin 1 induces interleukin 1. I. Induction of circulating interleukin 1 in rabbits in vivo and in human mononuclear cells in vitro.

1987 • 545 citations

Isolation and characterization of a mouse interleukin cDNA clone that expresses B-cell stimulatory factor 1 activities and T-cell- and mast-cell-stimulating activities.

1986 • 529 citations

An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF family

1987 • 525 citations

Nucleotide sequence of epidermal growth factor cDNA predicts a 128,000-molecular weight protein precursor

1983 • 520 citations

Induction of interleukin 2 receptor gene expression by p40x encoded by human T-cell leukemia virus type 1.

1986 • 519 citations

Binding of different dimeric forms of PDGF to human fibroblasts: evidence for two separate receptor types.

1988 • 514 citations

Structure and expression of cDNA and genes for human interferon-beta-2, a distinct species inducible by growth-stimulatory cytokines.

1986 • 505 citations

Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter

1986 • 480 citations

AIDS-Kaposi's Sarcoma-Derived Cells Express Cytokines with Autocrine and Paracrine Growth Effects

1989 • 476 citations

Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity.

1988 • 458 citations

Structure of a Mouse Submaxillary Messenger RNA Encoding Epidermal Growth Factor and Seven Related Proteins

1983 • 448 citations

Evidence for aberrant activation of the interleukin-2 autocrine loop by HTLV-1-encoded p40x and T3/Ti complex triggering

1987 • 438 citations

The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors.

1988 • 425 citations

A human osteosarcoma cell line secretes a growth factor structurally related to a homodimer of PDGF A-chains

1986 • 418 citations

Activation of interleukin 2 and interleukin 2 receptor (Tac) promoter expression by the trans-activator (tat) gene product of human T-cell leukemia virus, type I.

1987 • 413 citations

Insulin-like growth factor-II gene expression in Wilms' tumour and embryonic tissues

1985 • 413 citations

Transforming growth factors produced by retrovirus-transformed rodent fibroblasts and human melanoma cells: amino acid sequence homology with epidermal growth factor.

1983 • 403 citations

Sarcoma growth factor from conditioned medium of virally transformed cells is composed of both type alpha and type beta transforming growth factors.

1983 • 381 citations

Allosteric regulation of the epidermal growth factor receptor kinase.

1986 • 381 citations

Basic fibroblast growth factor fused to a signal peptide transforms cells

1988 • 379 citations

Human interleukin-2 promotes proliferation of activated B cells via surface receptors similar to those of activated T cells

1984 • 375 citations

Developmentally regulated production of platelet-derived growth factor-like molecules

1984 • 368 citations

Fibroblast growth factor

1986 • 367 citations

Dimerization of B-type Platelet-derived Growth Factor Receptors Occurs After Ligand Binding and Is Closely Associated with Receptor Kinase Activation

1989 • 366 citations

Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulin.

1988 • 357 citations

B cell stimulatory factor-1/interleukin-4 mRNA is expressed by normal and transformed mast cells

1987 • 355 citations

Expression of messenger RNAs for platelet-derived growth factor and transforming growth factor-alpha and their receptors in human malignant glioma cell lines.

1988 • 354 citations

Expression of insulin-like growth factor-II transcripts in Wilms' tumour

1985 • 352 citations

Expression in rat fibroblasts of a human transforming growth factor-α cDNA results in transformation

1986 • 346 citations

Structural analysis of the sequence coding for an inducible 26‐kDa protein in human fibroblasts

1986 • 343 citations

Constitutive synthesis of interleukin-3 by leukaemia cell line WEHI-3B is due to retroviral insertion near the gene

1985 • 333 citations

c-myc gene expression is stimulated by agents that activate protein kinase C and does not account for the mitogenic effect of PDGF

1985 • 331 citations

Neoplastic transformation of mast cells by Abelson-MuLV: abrogation of IL-3 dependence by a nonautocrine mechanism

1985 • 330 citations

Coexpression of the sis and myc proto-oncogenes in developing human placenta suggests autocrine control of trophoblast growth

1985 • 328 citations

Antiphosphotyrosine Recovery of Phospholipase C Activity After EGF Treatment of A-431 Cells

1988 • 324 citations

A major part of platelet-derived growth factor purified from human platelets is a heterodimer of one A and one B chain.

1988 • 317 citations

Secretion of an insulin-like growth factor-I-related protein by human breast cancer cells.

1986 • 310 citations

Nucleotide sequence of the simian sarcoma virus genome: demonstration that its acquired cellular sequences encode the transforming gene product p28sis.

1983 • 293 citations

cDNA sequence of human transforming gene hst and identification of the coding sequence required for transforming activity.

1987 • 293 citations

Endothelial cell hyperplasia in human glioblastoma: coexpression of mRNA for platelet-derived growth factor (PDGF) B chain and PDGF receptor suggests autocrine growth stimulation.

1988 • 288 citations

Constitutive overexpression of a growth-regulated gene in transformed Chinese hamster and human cells.

1987 • 283 citations

Autocrine secretion of GM-CSF in acute myeloblastic leukemia

1986 • 280 citations

Receptors for B-cell stimulatory factor-1 expressed on cells of haematopoietic lineage

1987 • 280 citations

Transforming protein of simian sarcoma virus stimulates autocrine growth of SSV-transformed cells through PDGF cell-surface receptors

1984 • 277 citations

Transforming gene from human stomach cancers and a noncancerous portion of stomach mucosa.

1986 • 277 citations

Expression of a hemopoietic growth factor cDNA in a factor-dependent cell line results in autonomous growth and tumorigenicity

1985 • 273 citations

Malignant transformation of a growth factor-dependent myeloid cell line by Abelson virus without evidence of an autocrine mechanism

1985 • 272 citations

Efficient reversion of simian sarcoma virus-transformation and inhibition of growth factor-induced mitogenesis by suramin.

1986 • 270 citations

Selective stimulation of small cell lung cancer clonal growth by bombesin and gastrin-releasing peptide

1987 • 269 citations

Autocrine Stimulation of Intracellular PDGF Receptors in v- sis -Transformed Cells

1988 • 267 citations

Synthesis and secretion of platelet-derived growth factor by human breast cancer cell lines.

1987 • 266 citations

A glioma-derived PDGF a chain homodimer has different functional activities from a PDGF AB heterodimer purified from human platelets

1988 • 264 citations

Different transforming growth factor-α species are derived from a glycosylated and palmitoylated transmembrane precursor

1987 • 264 citations

Purification and properties of porcine platelet-derived growth factor.

1984 • 260 citations

The Platelet-derived Growth Factor-inducible KC Gene Encodes a Secretory Protein Related to Platelet α-Granule Proteins

1989 • 257 citations

Platelet-derived growth factor induces multisite phosphorylation of pp60c-src and increases its protein-tyrosine kinase activity.

1988 • 250 citations

Both normal and tumor cells produce basic fibroblast growth factor

1986 • 250 citations

Human tumor cells synthesize an endothelial cell growth factor that is structurally related to basic fibroblast growth factor.

1986 • 247 citations

Expression of a Platelet-Derived Growth Factor-Like Protein in Simian Sarcoma Virus Transformed Cells

1983 • 246 citations

Kirsten murine sarcoma virus transformed cell lines and a spontaneously transformed rat cell‐line produce transforming factors

1980 • 244 citations

Constitutive expression of the granulocyte-macrophage colony-stimulating factor gene in acute myeloblastic leukemia.

1987 • 239 citations

Coexpression of a PDGF-like growth factor and PDGF receptors in a human osteosarcoma cell line: Implications for autocrine receptor activation

1984 • 238 citations

Purification and characterization of vaccinia virus growth factor

1985 • 238 citations

Signal Transduction Through the EGF Receptor Transfected in IL-3-Dependent Hematopoietic Cells

1988 • 238 citations

bFGF as an autocrine growth factor for human melanomas.

1988 • 237 citations

Sequence, topography and protein coding potential of mouse int-2: a putative oncogene activated by mouse mammary tumour virus.

1986 • 234 citations

The Molecular Control of Blood Cell Development

1987 • 234 citations

PDGF A chain homodimers drive proliferation of bipotential (O-2A) glial progenitor cells in the developing rat optic nerve.

1989 • 234 citations

Possible positive autocrine feedback in the prereplicative phase of human fibroblasts

1987 • 234 citations

Production of platelet-derived growth factor-like molecules and reduced expression of platelet-derived growth factor receptors accompany transformation by a wide spectrum of agents.

1984 • 233 citations

Arterial smooth muscle cells in primary culture produce a platelet-derived growth factor-like protein.

1985 • 231 citations

‘B-cell factors’ are pleiotropic

1988 • 230 citations

Production of transforming growth factor alpha in human pancreatic cancer cells: evidence for a superagonist autocrine cycle.

1987 • 230 citations

Platelet-derived growth factor

1985 • 226 citations

Transforming growth factor(s) production enables cells to grow in the absence of serum: an autocrine system.

1982 • 219 citations

Growth Regulating Substances for Animal Cells in Culture.

1968 • 210 citations

Growth-related changes in specific mRNAs of cultured mouse cells.

1983 • 209 citations

The product of the protooncogene c-src is modified during the cellular response to platelet-derived growth factor.

1985 • 207 citations

Anti-beta-interferon antibodies inhibit the increased expression of HLA-B7 mRNA in tumor necrosis factor-treated human fibroblasts: structural studies of the beta 2 interferon involved.

1986 • 207 citations

Antibodies against platelet-derived growth factor inhibit acute transformation by simian sarcoma virus

1985 • 205 citations

Immortalized B lymphocytes produce B-cell growth factor

1984 • 204 citations

High-affinity receptors for peptides of the bombesin family in Swiss 3T3 cells.

1985 • 202 citations

Pituitary follicular cells produce basic fibroblast growth factor.

1987 • 200 citations

Human vascular smooth muscle cells both express and respond to heparin-binding growth factor I (endothelial cell growth factor).

1987 • 194 citations

Human melanoma cell lines of primary and metastatic origin express the genes encoding the chains of platelet-derived growth factor (PDGF) and produce a PDGF-like growth factor.

1986 • 187 citations

Transformation of NIH 3T3 cells by a human c-sis cDNA clone

1984 • 181 citations

Structural and biological characteristics of connective tissue activating peptide (CTAP-III), a major human platelet-derived growth factor.

1983 • 181 citations

Comparison of Biological Properties and Transforming Potential of Human PDGF-A and PDGF-B Chains

1988 • 178 citations

Processing, secretion, and biological properties of a novel growth factor of the fibroblast growth factor family with oncogenic potential.

1988 • 171 citations

Expression of the normal human sis/PDGF-2 coding sequence induces cellular transformation

1984 • 170 citations

Blockade of autocrine stimulation in simian sarcoma virus-transformed cells reverses down-regulation of platelet-derived growth factor receptors.

1984 • 163 citations

Rat skeletal myoblasts and arterial smooth muscle cells express the gene for the A chain but not the gene for the B chain (c-sis) of platelet-derived growth factor (PDGF) and produce a PDGF-like protein.

1986 • 162 citations

Construction of a Novel Oncogene Based on Synthetic Sequences Encoding Epidermal Growth Factor

1987 • 162 citations

Autocrine stimulation after transfer of the granulocyte/macrophage colony-stimulating factor gene and autonomous growth are distinct but interdependent steps in the oncogenic pathway.

1987 • 161 citations

Autocrine growth induced by src-related oncogenes in transformed chicken myeloid cells

1984 • 159 citations

v-erbA cooperates with sarcoma oncogenes in leukemic cell transformation

1986 • 156 citations

An angiogenic growth factor is expressed in human glioma cells.

1987 • 152 citations

Frequent expression of growth factors for mesenchymal cells in human mammary carcinoma cell lines.

1987 • 151 citations

Basic fibroblast growth factor in human rhabdomyosarcoma cells: implications for the proliferation and neovascularization of myoblast-derived tumors.

1987 • 151 citations

Transformation of mouse BALB/c 3T3 cells with human basic fibroblast growth factor cDNA.

1988 • 150 citations

Expression of acidic fibroblast growth factor cDNA confers growth advantage and tumorigenesis to Swiss 3T3 cells.

1988 • 149 citations

Rapid turnover of the platelet-derived growth factor receptor in sis-transformed cells and reversal by suramin. Implications for the mechanism of autocrine transformation.

1988 • 147 citations

Vaccinia virus-infected cells release a novel polypeptide functionally related to transforming and epidermal growth factors.

1985 • 146 citations

T-Cell Growth Factor Gene: Lack of Expression in Human T-Cell Leukemia-Lymphoma Virus-Infected Cells

1984 • 145 citations

B-cell stimulatory factor 1 and not interleukin 2 is the autocrine growth factor for some helper T lymphocytes.

1987 • 141 citations

Evidence That the v- sis Gene Product Transforms by Interaction with the Receptor for Platelet-Derived Growth Factor

1985 • 138 citations

Simian Sarcoma Virus—Transformed Cells Secrete a Mitogen Identical to Platelet-Derived Growth Factor

1984 • 137 citations

Expression of human basic fibroblast growth factor cDNA in baby hamster kidney-derived cells results in autonomous cell growth.

1988 • 134 citations

Trans-Activator Gene of HTLV-II Induces IL-2 Receptor and IL-2 Cellular Gene Expression

1986 • 129 citations

Transforming Potential of Human c- sis Nucleotide Sequences Encoding Platelet-Derived Growth Factor

1984 • 127 citations

High-molecular-weight transforming growth factor activity in the urine of patients with disseminated cancer.

1983 • 122 citations

Expression of insulin-like growth factor-I and -II genes in human smooth muscle tumours.

1988 • 121 citations

Hormones and cell culture

1979 • 121 citations

Production of PDGF‐like growth factor by breast cancer cell lines

1985 • 120 citations

Identification of genes involved in growth autonomy of hematopoietic cells by analysis of factor-independent mutants

1988 • 118 citations

The int genes in mammary tumorigenesis and in normal development

1988 • 117 citations

The amplification unit on chromosome 11q13 in aggressive primary human breast tumors entails the bcl-1, int-2 and hst loci.

1989 • 114 citations

Human HST1 (HSTF1) gene maps to chromosome band 11q13 and coamplifies with the INT2 gene in human cancer.

1988 • 111 citations

Integral membrane glycoprotein properties of the prohormone pro-transforming growth factor-α

1987 • 110 citations

Protein-Tryosine Kinases

1985 • 109 citations

Transformation Induced by Abelson Murine Leukemia Virus Involves Production of a Polypeptide Growth Factor

1982 • 108 citations

Interleukin 4 mediates autocrine growth of helper T cells after antigenic stimulation.

1986 • 106 citations

Release of autocrine growth factor by primary and immortalized Schwann cells.

1987 • 103 citations

Different effects of homo- and heterodimers of platelet-derived growth factor A and B chains on human and mouse fibroblasts.

1988 • 102 citations

Theileria parva infection induces autocrine growth of bovine lymphocytes.

1988 • 101 citations

Expression and characterization of transforming growth factor alpha precursor protein in transfected mammalian cells.

1987 • 100 citations

v-mil induces autocrine growth and enhanced tumorigenicity in v-myc-transformed avian macrophages

1986 • 100 citations

Transformation of normal rat kidney (NRK) cells by an infectious retrovirus carrying a synthetic rat type alpha transforming growth factor gene.

1987 • 100 citations

Autocrine growth of interleukin 2-producing leukemic cells in a patient with adult T cell leukemia

1986 • 98 citations

Insulinlike growth factor II expression and oval cell proliferation associated with hepatocarcinogenesis in woodchuck hepatitis virus carriers

1988 • 98 citations

Aberrant expression of receptors for platelet-derived growth factor in an anaplastic thyroid carcinoma cell line.

1988 • 98 citations

Autogenous production of a hemopoietic growth factor, persisting-cell-stimulating factor, as a mechanism for transformation of bone marrow-derived cells.

1983 • 97 citations

Platelet-derived Growth Factor-inducible Gene JE Is a Member of a Family of Small Inducible Genes Related to Platelet Factor 4

1989 • 90 citations

Molecular Analysis of the Interleukin‐2 System

1986 • 89 citations

A human glioma cell line secretes three structurally and functionally different dimeric forms of platelet‐derived growth factor

1988 • 88 citations

Autocrine growth stimulation of a human T-cell lymphoma line by interleukin 2.

1985 • 86 citations

A Common PDGF rEceptor Is Activated by Homodimeric A and B Forms of PDGF

1988 • 85 citations

Subversion of growth regulatory pathways in malignant transformation

1987 • 84 citations

Mutants of the elongation factor EF-Tu, a new class of nonsense suppressors.

1985 • 82 citations

Growth Factor and Cytogenetic Abnormalities in Cultured Nevi and Malignant Melanomas

1986 • 78 citations

Differential expression of platelet‐derived growth factor and transforming growth factor genes in small‐ and non‐small‐cell human lung carcinoma lines

1988 • 78 citations

Induction of platelet-derived growth factor gene expression during megakaryoblastic and monocytic differentiation of human leukemia cell lines.

1987 • 77 citations

The human transforming growth factor type alpha coding sequence is not a direct-acting oncogene when overexpressed in NIH 3T3 cells.

1987 • 73 citations

Platelet-derived growth factor agonist activity of a secreted form of the v-sis oncogene product.

1985 • 72 citations

Expression of recombinant platelet-derived growth factor A- and B-chain homodimers in rat-1 cells and human fibroblasts reveals differences in protein processing and autocrine effects.

1988 • 71 citations

Requirement for a Signal Sequence in Biological Expression of the v- sis Oncogene

1984 • 69 citations

Effects of bombesin antagonists on the growth of small cell lung cancer cells in vitro

1989 • 67 citations

Proliferation of buffalo rat liver cells in serum-free medium does not depend upon multiplication-stimulating activity (MSA)

1977 • 65 citations

The Parodi-Irgens feline sarcoma virus and simian sarcoma virus have homologous oncogenes, but in different contexts of the viral genomes

1983 • 65 citations

Induction of c-sis gene expression and synthesis of platelet-derived growth factor in human myeloid leukemia cells during monocytic differentiation.

1986 • 64 citations

Polyoma virus-transformed cells produce transforming growth factor(s) and grow in serum-free medium

1982 • 64 citations

Autocrine stimulation by the v-sis gene product requires a ligand-receptor interaction at the cell surface.

1988 • 64 citations

Mechanism of Autocrine Stimulation in Hematopoietic Cells Producing Interleukin-3 after Retrovirus-Mediated Gene Transfer

1989 • 62 citations

A viral long terminal repeat in the interleukin 2 gene of a cell line that constitutively produces interleukin 2.

1985 • 62 citations

Human oncogenes detected by a defined medium culture assay.

1987 • 61 citations

Evidence for autocrine mitogenic stimulation by somatomedin-C/insulin-like growth factor I on an established human lung cancer cell line

1989 • 61 citations

In vitro mutagenesis of the v-sis transforming gene defines functional domains of its growth factor-related product.

1985 • 54 citations

Mechanism of autocrine stimulation in hematopoietic cells producing interleukin-3 after retrovirus-mediated gene transfer.

1989 • 49 citations

Production of an insulin-like growth factor by osteosarcoma

1984 • 46 citations

Interferons in cell growth and development

1989 • 44 citations

The Role of Polypeptide Growth Factors in Phenotypic Transformation of Normal Rat Kidney Cells

1989 • 43 citations

Similar transforming growth factors (TGFs) produced by cells transformed by different isolates of feline sarcoma virus

1983 • 39 citations

Expression of epidermal growth factor and transforming growth factor-beta in human salivary gland adenocarcinoma cell line.

1985 • 38 citations

The role of polypeptide growth factors in phenotypic transformation of normal rat kidney cells.

1988 • 35 citations

Antibodies against basic fibroblast growth factor inhibit the autocrine growth of pulmonary artery endothelial cells

1988 • 32 citations

Preparation of a monoclonal antibody to a melanoma growth‐stimulatory activity released into serum‐free culture medium by Hs0294 malignant melanoma cells

1987 • 31 citations

Malignant transformation of murine fibroblasts by a human c-Ha-ras-1 oncogene does not require a functional epidermal growth factor receptor.

1986 • 28 citations

Temperature-sensitive mutants of MH2 avian leukemia virus that map in the v-mil and the v-myc oncogene respectively.

1986 • 27 citations

Integration of the BALB/c ecotropic provirus into the colony-stimulating factor-1 growth factor locus in a myc retrovirus-induced murine monocyte tumor

1988 • 27 citations

Autocrine growth induced by the insulin-related factor in the insulin-independent teratoma cell line 1246-3A.

1988 • 20 citations

In vitro growth promotion in human malignant melanoma cells by fibroblast growth factor.

1982 • 17 citations

Oncogenes and cell cycle genes

1987 • 9 citations

Growth regulating substances for animal cells in cultures

1969 • 3 citations