Effect of hyperglycemia and hyperinsulinemia on the response of IL-6, TNF-α, and FFAs to low-dose endotoxemia in humans

Intensive Insulin Therapy in Critically Ill Patients

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Glucose clamp technique: a method for quantifying insulin secretion and resistance.

1979 • 7,240 citations

Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis

2001 • 5,900 citations

Effect of Treatment With Low Doses of Hydrocortisone and Fludrocortisone on Mortality in Patients With Septic Shock

2002 • 3,043 citations

Oxidative Stress and Stress-Activated Signaling Pathways: A Unifying Hypothesis of Type 2 Diabetes

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Tumor Necrosis Factor (TNF)

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Inflammatory Cytokine Concentrations Are Acutely Increased by Hyperglycemia in Humans

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Treatment of Gram-Negative Bacteremia and Septic Shock with HA-1A Human Monoclonal Antibody against Endotoxin

1991 • 1,611 citations

Sepsis and septic shock—A review of laboratory models and a proposal

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Cytokine-Associated Emotional and Cognitive Disturbances in Humans

2001 • 1,317 citations

Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and β‐cell dysfunction

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Treatment of Septic Shock with the Tumor Necrosis Factor Receptor:Fc Fusion Protein

1996 • 1,217 citations

Stress-Induced Hyperglycemia

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Immune dysfunction in patients with diabetes mellitus (DM)

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IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans

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Pro-inflammatory cytokines and adipose tissue

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Confirmatory interleukin-1 receptor antagonist trial in severe sepsis

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Efficacy and Safety of Monoclonal Antibody to Human Tumor Necrosis Factor α in Patients With Sepsis Syndrome

1995 • 805 citations

The role of TNFα and TNF receptors in obesity and insulin resistance

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Exercise and IL‐6 infusion inhibit endotoxin‐induced TNF‐α production in humans

2003 • 730 citations

Interleukin-6 Stimulates Lipolysis and Fat Oxidation in Humans

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Tumor necrosis factor Characterization at the molecular, cellular and in vivo level

1991 • 708 citations

Potential Role of TNF-α in the Pathogenesis of Insulin Resistance and Type 2 Diabetes

2000 • 692 citations

Double-blind randomised controlled trial of monoclonal antibody to human tumour necrosis factor in treatment of septic shock. NORASEPT II Study Group.

1998 • 618 citations

T cell activation-associated hepatic injury: mediation by tumor necrosis factors and protection by interleukin 6.

1994 • 519 citations

Treatment of Septic Shock with Human Monoclonal Antibody HA-1A

1994 • 474 citations

Double-blind randomised controlled trial of monoclonal antibody to human tumour necrosis factor in treatment of septic shock

1998 • 458 citations

Overnight lowering of free fatty acids with Acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects.

1999 • 425 citations

Insulin resistance in type 2 diabetes: role of fatty acids

2002 • 319 citations

Profiling Gene Transcription In Vivo Reveals Adipose Tissue as an Immediate Target of Tumor Necrosis Factor-α

2002 • 292 citations

Effects of glucocorticoid excess on the sensitivity of glucose transport and metabolism to insulin in rat skeletal muscle

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Tumor necrosis factor mimics the metabolic response to acute infection in healthy humans

1991 • 232 citations

Experimental models of Gram-negative sepsis

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Interaction between free fatty acids and glucose metabolism

2002 • 221 citations

Dose-dependent effects of endotoxin on human sleep

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Stimulation of lipolysis in cultured fat cells by tumor necrosis factor, interleukin-1, and the interferons is blocked by inhibition of prostaglandin synthesis.

1992 • 184 citations

Metabolic effects of interleukin‐6 in human splanchnic and adipose tissue

2002 • 153 citations

Insulin stimulates interleukin-6 and tumor necrosis factor-α gene expression in human subcutaneous adipose tissue

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Anti-gamma interferon and anti-interleukin-6 antibodies affect staphylococcal enterotoxin B-induced weight loss, hypoglycemia, and cytokine release in D-galactosamine-sensitized and unsensitized mice

1995 • 134 citations

Properties of Reference Escherichia coli Endotoxin and Its Phthalylated Derivative in Humans

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Effect of epinephrine on glucose metabolism in humans: contribution of the liver

1984 • 118 citations

Euglycemic hyperinsulinemia augments the cytokine and endocrine responses to endotoxin in humans

2002 • 116 citations

Influence of acute hyperglycemia in human sepsis on inflammatory cytokine and counterregulatory hormone concentrations

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Characterization of vectorial chloride transport pathways in the human pancreatic duct adenocarcinoma cell line HPAF

2003 • 82 citations

Alterations in Lipid and Carbohydrate Metabolism in Sepsis

1988 • 73 citations

METABOLIC DERANGEMENTS IN SEPSIS AND SEPTIC SHOCK

2000 • 71 citations

Alterations in the early steps of the insulin-signaling system in skeletal muscle of GH-transgenic mice

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Short-term hyperglycemia induces lymphopenia and lymphocyte subset redistribution

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Impaired glucose and lipid metabolism seen in intensive care patients is related to severity of illness and survival.

1994 • 62 citations

Inhibition of the Rise in FFA by Acipimox Partially Prevents GH-Induced Insulin Resistance in GH-Deficient Adults

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Epinephrine acutely mediates skeletal muscle insulin resistance.

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Effects of Total Parenteral Nutrition with Nucleoside and Nucleotide Mixture on D‐Galactosamine‐Induced Liver Injury in Rats

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Regulation of glucose metabolism by norepinephrine in conscious dogs

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Effects of epinephrine on human muscle glucose and protein metabolism

1995 • 46 citations

The role of increased liver triglyceride content: a culprit of diabetic hyperglycaemia?

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Short-term effects of tumor necrosis factor on energy and substrate metabolism in dogs.

1993 • 35 citations

THE SYSTEMIC INFLAMMATORY RESPONSE

1996 • 34 citations

Acute lowering of circulating fatty acids improves insulin secretion in a subset of type 2 diabetes subjects

2003 • 32 citations

THE SYSTEMIC INFLAMMATORY RESPONSE

1996 • 31 citations

Activated T Lymphocytes Disappear from Circulation during Endotoxemia in Humans

2002 • 27 citations

Increasing the Efficacy of Anti-Inflammatory Agents Used in the Treatment of Sepsis

2003 • 26 citations

Deleted Work

1955 • 0 citations