High level expression of ΔN-p63: a mechanism for the inactivation of p53 in undifferentiated nasopharyngeal carcinoma (NPC)?

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Mdm2 promotes the rapid degradation of p53

1997 • 4,336 citations

Regulation of p53 stability by Mdm2

1997 • 3,238 citations

p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

1999 • 2,179 citations

p63, a p53 Homolog at 3q27–29, Encodes Multiple Products with Transactivating, Death-Inducing, and Dominant-Negative Activities

1998 • 2,061 citations

p63 is a p53 homologue required for limb and epidermal morphogenesis

1999 • 1,963 citations

Amplification of a gene encoding a p53-associated protein in human sarcomas

1992 • 1,959 citations

Monoallelically Expressed Gene Related to p53 at 1p36, a Region Frequently Deleted in Neuroblastoma and Other Human Cancers

1997 • 1,636 citations

ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways

1998 • 1,584 citations

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

1995 • 1,500 citations

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

1993 • 1,445 citations

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

1998 • 1,248 citations

The alternative product from the human CDKN2A locus, p14ARF, participates in a regulatory feedback loop with p53 and MDM2

1998 • 1,152 citations

The p16INK4a/CDKN2A tumor suppressor and its relatives

1998 • 917 citations

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

1999 • 828 citations

Association of p53 Protein Expression With Tumor Cell Proliferation Rate and Clinical Outcome in Node-Negative Breast Cancer

1993 • 777 citations

Tumor surveillance via the ARF–p53 pathway

1998 • 735 citations

INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53

1999 • 455 citations

Association of p63 with Proliferative Potential in Normal and Neoplastic Human Keratinocytes

1999 • 416 citations

Mutations in Human ARF Exon 2 Disrupt Its Nucleolar Localization and Impair Its Ability to Block Nuclear Export of MDM2 and p53

1999 • 343 citations

Epstein-Barr virus latent membrane protein 1 blocks p53-mediated apoptosis through the induction of the A20 gene

1996 • 259 citations

The CDKN2A (p16) Gene and Human Cancer

1997 • 247 citations

Interactions of human papillomavirus transforming proteins with the products of tumor suppressor genes

1993 • 185 citations

The p53 gene family

1999 • 174 citations

Mechanisms of p16INK4A inactivation in non small-cell lung cancers

1998 • 164 citations

An infrequent point mutation of the p53 gene in human nasopharyngeal carcinoma.

1992 • 143 citations

p16 gene alterations in nasopharyngeal carcinoma.

1995 • 139 citations

Alterations of the p53 gene in nasopharyngeal carcinoma

1992 • 137 citations

Overexpression of MDM2, due to enhanced translation, results in inactivation of wild-type p53 in Burkitt's lymphoma cells

1998 • 127 citations

p53 mutations implicate sunlight in post-transplant skin cancer irrespective of human papillomarivus status

1997 • 96 citations

P53 overexpression and Epstein‐Barr virus infection in undifferentiated and squamous cell nasopharyngeal carcinomas

1993 • 94 citations

M.A. Epstein and B.G. Achong, The Epstein-Barr virus Berlin, Heidelberg, New York (Springer-Verlag ed.) (1979).

1982 • 92 citations

Epstein–Barr virus infection and the pathogenesis of nasopharyngeal carcinoma: viral gene expression, tumour cell phenotype, and the role of the lymphoid stroma

1996 • 86 citations

Assessment of p53 expression in nasopharyngeal carcinoma*1

1995 • 77 citations

Association of Epstein–Barr virus infection with p53 protein accumulation but not bcl‐2 protein in nasopharyngeal carcinoma

1999 • 43 citations