Glucocorticoids Affect Human Dendritic Cell Differentiation and Maturation

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

Physiological Functions of Glucocorticoids in Stress and Their Relation to Pharmacological Actions*

1984 • 3,073 citations

Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products.

1995 • 2,531 citations

Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis

1995 • 2,386 citations

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.

1996 • 2,032 citations

Proliferating dendritic cell progenitors in human blood.

1994 • 1,922 citations

GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cells

1992 • 1,608 citations

Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells.

1995 • 1,560 citations

Dendritic Cells: Unique Leukocyte Populations Which Control the Primary Immune Response

1997 • 1,536 citations

Control of Cachectin (Tumor Necrosis Factor) Synthesis: Mechanisms of Endotoxin Resistance

1986 • 1,305 citations

Generation of mature dendritic cells from human blood An improved method with special regard to clinical applicability

1996 • 1,138 citations

CD14+ blood monocytes can differentiate into functionally mature CD83+ dendritic cells.

1996 • 1,105 citations

Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family

1995 • 810 citations

Expression of relB is required for the development of thymic medulla and dendritic cells

1995 • 794 citations

Interleukin (IL)-10 Inhibits Nuclear Factor кB (NFкB) Activation in Human Monocytes

1995 • 698 citations

Interleukin‐12 is produced by dendritic cells and mediates T helper 1 development as well as interferon‐γ production by T helper 1 cells

1996 • 676 citations

Corticosteroids inhibit murine macrophage Ia expression and interleukin 1 production.

1982 • 665 citations

Effect of interleukin‐10 on dendritic cell maturation and function

1997 • 571 citations

Inhibition of Langerhans cell antigen-presenting function by IL-10. A role for IL-10 in induction of tolerance.

1993 • 526 citations

Glucocorticoids selectively inhibit the transcription of the interleukin 1 beta gene and decrease the stability of interleukin 1 beta mRNA.

1988 • 510 citations

IL-10 prevents the differentiation of monocytes to dendritic cells but promotes their maturation to macrophages

1998 • 505 citations

The Stress Response and the Regulation of Inflammatory Disease

1992 • 469 citations

Dendritic Cells as Adjuvants for Immune-mediated Resistance to Tumors

1997 • 432 citations

Dendritic Cells as the Terminal Stage of Monocyte Differentiation

1998 • 405 citations

Dexamethasone-mediated inhibition of human T cell growth factor and gamma-interferon messenger RNA.

1984 • 390 citations

Glucocorticoids inhibit transcriptional and post-transcriptional expression of interleukin 1 in U937 cells.

1987 • 376 citations

Differentiation of human dendritic cells from monocytes in vitro

1997 • 356 citations

Corticosteroids inhibit IL-12 production in human monocytes and enhance their capacity to induce IL-4 synthesis in CD4+ lymphocytes.

1997 • 349 citations

Changes in Blood Hormone Levels during the Immune Response

1975 • 342 citations

Regulation of cytokine and cytokine receptor expression by glucocorticoids

1996 • 326 citations

Interleukin‐10 differentially regulates B7‐1 (CD80) and B7‐2 (CD86) expression on human peripheral blood dendritic cells

1995 • 282 citations

Analysis of the suppression of IL-1 alpha and IL-1 beta production in human peripheral blood mononuclear adherent cells by a glucocorticoid hormone.

1988 • 259 citations

Interleukin‐10 prevents the generation of dendritic cells from human peripheral blood mononuclear cells cultured with interleukin‐4 and granulocyte/ macrophage‐colony‐stimulating factor

1997 • 244 citations

Glucocorticoids inhibit the production of IL 6 from monocytes, endothelial cells and fibroblasts

1990 • 232 citations

Glucocorticoids down‐regulate dendritic cell function in vitro and in vivo

1995 • 220 citations

Human dendritic cell responses to lipopolysaccharide and CD40 ligation are differentially regulated by interleukin‐10

1997 • 210 citations

Inhibition by glucocorticoids of the formation of interleukin-1 alpha, interleukin-1 beta, and interleukin-6: mediation by decreased mRNA stability.

1993 • 202 citations

Identifying Strategies for Immune Intervention

1993 • 194 citations

Recent advances in the study of dendritic cells and follicular dendritic cells

1995 • 191 citations

Generation of immunostimulatory dendritic cells from human CD34+ hematopoietic progenitor cells of the bone marrow and peripheral blood.

1995 • 175 citations

Glucocorticosteroid action on the immune system: molecular and cellular aspects.

1991 • 154 citations

Expression of relB transcripts during lymphoid organ development: specific expression in dendritic antigen-presenting cells

1993 • 149 citations

Induction of high-affinity interleukin 1 receptor on human peripheral blood lymphocytes by glucocorticoid hormones.

1988 • 148 citations

Regulation of IL 3 expression by glucocorticoids in cloned murine T lymphocytes.

1985 • 147 citations

Effect of glucocorticosteroids on epidermal Langerhans cells.

1982 • 146 citations

Glucocorticoids suppress the production of interleukin 4 by human lymphocytes

1991 • 140 citations

Split activity of interleukin‐10 on antigen capture and antigen presentation by human dendritic cells: Definition of a maturative step

1997 • 126 citations

Coexpression of NF-kappa B/Rel and Sp1 transcription factors in human immunodeficiency virus 1-induced, dendritic cell-T-cell syncytia.

1995 • 115 citations

IL-13 supports differentiation of dendritic cells from circulating precursors in concert with GM-CSF.

1995 • 111 citations

Macrophages and the glucocorticoids

1992 • 107 citations

Regulated expression and release of the IL-1 decoy receptor in human mononuclear phagocytes.

1996 • 105 citations

A novel mechanism of glucocorticoid-induced immune suppression: the inhibiton of T cell-mediated terminal maturation of a murine dendritic cell line.

1996 • 99 citations

Surface membrane heterogeneity among human mononuclear phagocytes.

1984 • 95 citations

Corticosteroids enhance the binding of recombinant interferon-gamma to cultured human monocytes.

1986 • 75 citations

Steroids as Regulators of the Mammalian Immune Response

1995 • 69 citations

Differential nuclear localization of p50, p52, and RelB proteins in human accessory cells of the immune response in situ

1996 • 51 citations

Corticosteroid inhibition of macrophage inflammatory protein-1 alpha in human monocytes and alveolar macrophages

1995 • 47 citations

Dexamethasone up-regulates granulocyte-macrophage colony-stimulating factor receptor expression on human monocytes.

1994 • 43 citations

Dexamethasone Suppressed Gene Expression and Production of lnterleukin-10 by Human Peripheral Blood Mononuclear Cells and Monocytes

1997 • 40 citations

Inhibition of lysozyme synthesis by dexamethasone in human mononuclear leukocytes: an index of glucocorticoid sensitivity.

1994 • 35 citations

Degradation of tissue-type plasminogen activator by human monocyte- derived macrophages is mediated by the mannose receptor and by the low- density lipoprotein receptor-related protein

1995 • 32 citations

Glucocorticoid-Induced Alterations of Monocyte Defense Mechanisms against Candida albicans

1994 • 24 citations

DIFFERENTIAL REGULATION BY DEXAMETHASONE AND CYCLOSPORINE OF HUMAN T CELLS ACTIVATED BY VARIOUS STIMULI

1991 • 22 citations

Enhancement of human monocyte beta-glucan receptors by glucocorticoids.

1994 • 19 citations

Steroids as Regulators of the Mammalian Immune Response.

1995 • 15 citations

DIFFERENTIAL INHIBITION OF THE T CELL ACTIVATION PATHWAY BY DEXAMETHASONE AND CYCLOSPORINE

1990 • 15 citations

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