Coagulation inhibitor replacement during sepsis: Useless?

Circulating adhesion molecules in disease

1993 • 1,425 citations

The Pathogenesis of Sepsis

1991 • 1,376 citations

Multiple-Organ Failure

1985 • 1,314 citations

Yearbook of Intensive Care and Emergency Medicine 2002

2002 • 883 citations

The microcirculation and inflammation: modulation of leukocyte-endothelial cell adhesion

1994 • 863 citations

Multiple Organ Failure

1999 • 820 citations

Experimental endotoxemia in humans: analysis of cytokine release and coagulation, fibrinolytic, and complement pathways

1990 • 796 citations

Septic Shock, Multiple Organ Failure, and Disseminated Intravascular Coagulation

1992 • 708 citations

Activation of Coagulation after Administration of Tumor Necrosis Factor to Normal Subjects

1990 • 681 citations

Experimental endotoxemia in humans: analysis of cytokine release and coagulation, fibrinolytic, and complement pathways

1990 • 611 citations

Elimination of interleukin 6 attenuates coagulation activation in experimental endotoxemia in chimpanzees.

1994 • 387 citations

Microvascular perfusion is impaired in a rat model of normotensive sepsis.

1994 • 361 citations

Pathogenesis of Disseminated Intravascular Coagulation in Sepsis

1993 • 349 citations

Derangements of Coagulation and Fibrinolysis in Critically III Patients with Sepsis and Septic Shock

1998 • 300 citations

The contact system contributes to hypotension but not disseminated intravascular coagulation in lethal bacteremia. In vivo use of a monoclonal anti-factor XII antibody to block contact activation in baboons.

1993 • 276 citations

Septic shock

1998 • 255 citations

Antithrombin III (ATILL) replacement therapy in patients with sepsis and/or postsurgical complications: a controlled double-blind, randomized, multicenter study

1998 • 230 citations

Substitution of antithrombin III in shock and DIC: A randomized study

1985 • 207 citations

Tumor necrosis factor alpha regulates in vivo intrapulmonary expression of ICAM-1.

1993 • 205 citations

Disseminated Intravascular Coagulation Is a Frequent Complication of Systemic Inflammatory Response Syndrome

1996 • 199 citations

The microcirculation during endotoxemia

1996 • 197 citations

Coagulation, fibrinolysis, and kallikrein systems in sepsis

1989 • 159 citations

Differential effects of anti-tumor necrosis factor monoclonal antibodies on systemic inflammatory responses in experimental endotoxemia in chimpanzees

1994 • 150 citations

Disseminated Intravascular Coagulation: Pathophysiological Mechanisms and Manifestations

1998 • 142 citations

Circulating ICAM-1 is increased in septic shock.

1995 • 135 citations

The proinflammatory cytokine response to coagulation and endotoxin in whole blood

1996 • 116 citations

Differential effects of anti-tumor necrosis factor monoclonal antibodies on systemic inflammatory responses in experimental endotoxemia in chimpanzees

1994 • 108 citations

EFFECT OF ANTITHROMBIN III SUPPLEMENTATION ON INFLAMMATORY RESPONSE IN PATIENTS WITH SEVERE SEPSIS

1998 • 105 citations

Activation of the contact system of plasma proteolysis in the adult respiratory distress syndrome.

1988 • 89 citations

Coagulation disorders in septic shock

1993 • 85 citations

Differential roles of selectins and the alpha4-integrin in acute, subacute, and chronic leukocyte recruitment in vivo.

1997 • 78 citations

Antithrombin reduces leukocyte adhesion during chronic endotoxemia by modulation of the cyclooxygenase pathway

2000 • 75 citations

Vascular Effects of Thrombin

1992 • 54 citations

Coagulation inhibitor substitution during sepsis

1995 • 51 citations

Effects of Human Antithrombin III on Mortality and Blood Coagulation Induced in Rabbits by Endotoxin

1984 • 51 citations

Role of leukocytes in the activation of intravascular coagulation in patients with septicemia

1991 • 43 citations

THE THROMBIN ANTAGONIST HIRUDIN FAILS TO INHIBIT ENDOTOXIN-INDUCED LEUKOCYTE/ENDOTHELIAL CELL INTERACTION AND MICROVASCULAR PERFUSION FAILURE

2000 • 40 citations

Antithrombin Levels Related to Infections and Outcome

1996 • 39 citations

Mediators of endotoxin-induced leukocyte adhesion in mesenteric postcapillary venules.

1994 • 38 citations

Sepsis and antithrombin III, prekallikrein, and fibronectin levels in surgical patients.

1989 • 34 citations

The effect of heparin on multiple organ failure and disseminated intravascular coagulation in a sepsis model

1990 • 34 citations

Untitled

1999 • 14 citations

Comparison of the early dynamics of coagulation activation after injection of endotoxin and tumor necrosis factor in healthy humans.

1991 • 13 citations

Antithrombin Replacement in DIC and MOF

1995 • 12 citations

Uncontrolled plasma proteolysis: A major threat to the septicemic patient

1986 • 11 citations

New biological concepts on coagulation inhibitors

1993 • 9 citations

Mikrozirkulation und Hämostase bei entzündlichen Prozessen

1997 • 3 citations