Reconstitution of p53-ubiquitinylation reactions from purified components: the role of human ubiquitin-conjugating enzyme UBC4 and E6-associated protein (E6AP).

p53 Mutations in Human Cancers

1991 • 8,133 citations

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product

1989 • 3,036 citations

Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53

1990 • 2,587 citations

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

1993 • 2,329 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

p53 function and dysfunction

1992 • 1,918 citations

Protein ubiquitination involving an E1–E2–E3 enzyme ubiquitin thioester cascade

1995 • 960 citations

Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

1992 • 871 citations

p53-Dependent apoptosis in the absence of transcriptional activation of p53-target genes

1994 • 857 citations

Viruses in Human Cancers

1991 • 793 citations

THE UBIQUITIN-CONJUGATION SYSTEM

1992 • 561 citations

An immunochemical analysis of the human nuclear phosphoprotein p53

1992 • 533 citations

Ubiquitin-conjugating enzymes UBC4 and UBC5 mediate selective degradation of short-lived and abnormal proteins.

1990 • 520 citations

The N-end rule

1992 • 464 citations

Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6.

1991 • 266 citations

Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53.

1994 • 259 citations

Molecular cloning, sequence, and tissue distribution of the human ubiquitin-activating enzyme E1.

1991 • 129 citations

Performance of an automated system for capillary microinjection into living cells

1988 • 98 citations

Hormone-dependent transcriptional regulation and cellular transformation by Fos-steroid receptor fusion proteins.

1991 • 95 citations

Dhr6, a Drosophila homolog of the yeast DNA-repair gene RAD6.

1991 • 76 citations

A human ubiquitin-conjugating enzyme homologous to yeast UBC8.

1994 • 64 citations

cDNA cloning of a novel human ubiquitin carrier protein. An antigenic domain specifically recognized by endemic pemphigus foliaceus autoantibodies is encoded in a secondary reading frame of this human epidermal transcript.

1992 • 61 citations

The ubc-2 gene of Caenorhabditis elegans encodes a ubiquitin-conjugating enzyme involved in selective protein degradation.

1993 • 50 citations

The ubc-2 Gene of Caenorhabditis elegans Encodes a Ubiquitin-Conjugating Enzyme Involved in Selective Protein Degradation

1993 • 15 citations