The Enhancement of Hippocampal Primed Burst Potentiation by Dehydroepiandrosterone Sulfate (DHEAS) is Blocked by Psychological Stress

The Essential Role of Hippocampal CA1 NMDA Receptor–Dependent Synaptic Plasticity in Spatial Memory

1996 • 1,750 citations

Age Changes and Sex Differences in Serum Dehydroepiandrosterone Sulfate Concentrations throughout Adulthood

1984 • 1,345 citations

Neurosteroids: Endogenous bimodal modulators of the GABAA receptor mechanism of action and physiological significance

1992 • 1,098 citations

The Primate Hippocampal Formation: Evidence for a Time-Limited Role in Memory Storage

1990 • 883 citations

Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age.

1994 • 852 citations

Synaptic plasticity and learning: selective impairment of learning rats and blockade of long-term potentiation in vivo by the N-methyl-D- aspartate receptor antagonist AP5

1989 • 766 citations

Inverted‐U relationship between the level of peripheral corticosterone and the magnitude of hippocampal primed burst potentiation

1992 • 671 citations

Induction of Synaptic Potentiation in Hippocampus by Patterned Stimulation Involves Two Events

1986 • 603 citations

The NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro

1992 • 545 citations

Enduring effects of chronic corticosterone treatment on spatial learning, synaptic plasticity, and hippocampal neuropathology in young and mid-aged rats

1995 • 527 citations

Neurosteroids: A new brain function?

1990 • 526 citations

Inescapable versus Escapable Shock Modulates Long-Term Potentiation in the Rat Hippocampus

1989 • 458 citations

Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it.

1992 • 442 citations

Behavioral stress impairs long-term potentiation in rodent hippocampus

1987 • 441 citations

Behavioral stress modifies hippocampal plasticity through N-methyl-D-aspartate receptor activation.

1996 • 435 citations

Dehydroepiandrosterone (DHEA): a fountain of youth?

1996 • 364 citations

Spatial learning without NMDA receptor-dependent long-term potentiation

1995 • 326 citations

Effects of glucocorticoids on hippocampal long‐term potentiation

1993 • 320 citations

Dehydroepiandrosterone (DHEA) treatment of depression

1997 • 317 citations

Exposing Rats to a Predator Blocks Primed Burst Potentiation in the HippocampusIn Vitro

1999 • 275 citations

Dehydroepiandrosterone sulfate improves memory in aging mice

1988 • 262 citations

Opposing roles of type I and type II adrenal steroid receptors in hippocampal long-term potentiation

1995 • 259 citations

What does the hippocampus really do?

1995 • 248 citations

Properties and Mechanisms of Long-Term Synaptic Plasticity in the Mammalian Brain: Relationships to Learning and Memory

1995 • 248 citations

Induction of hippocampal long-term potentiation using physiologically patterned stimulation

1986 • 242 citations

Replacement of DHEA in Aging Men and Women

1995 • 239 citations

Glucocorticoid receptor and protein/RNA synthesis-dependent mechanisms underlie the control of synaptic plasticity by stress

1998 • 235 citations

Effects of a Two-Week Physiological Dehydroepiandrosterone Substitution on Cognitive Performance and Well-Being in Healthy Elderly Women and Men¹

1997 • 234 citations

Dehydroepiandrosterone and its sulfate enhance memory retention in mice

1988 • 232 citations

Characteristics of hippocampal primed burst potentiation in vitro and in the awake rat

1988 • 212 citations

Effects of dehydroepiandrosterone and its sulfate on brain tissue in culture and on memory in mice

1987 • 199 citations

Psychological stress repeatedly blocks hippocampal primed burst potentiation in behaving rats

1994 • 185 citations

Hippocampal plasticity induced by primed burst, but not long‐term potentiation, stimulation is impaired in area CA1 of aged fischer 344 rats

1993 • 170 citations

Plasma corticosterone concentrations sensitively reflect levels of stimulus intensity in the rat

1979 • 163 citations

Neurosteroids Affect Spatial/Reference, Working, and Long-Term Memory of Female Rats

1995 • 154 citations

Effect of Burn Trauma on Adrenal and Testicular Steroid Hormone Production*

1987 • 154 citations

Serotonin blocks the long-term potentiation induced by primed burst stimulation in the CA1 region of rat hippocampal slices

1992 • 137 citations

Spatial memory and N-methyl-D-aspartate receptor antagonists APV and MK-801: Memory impairments depend on familiarity with the environment, drug dose, and training duration.

1994 • 125 citations

Dehydroepiandrosterone (DHEA)–the Multifunctional Steroid

1994 • 125 citations

Serum Dehydroepiandrosterone (DHEA) and DHEA-Sulfate (DHEA-S) in Alzheimer's Disease and in Cerebrovascular Dementia.

1996 • 116 citations

Acute stress enhances the activity of the GABA receptor-gated chloride ion channel in brain

1987 • 113 citations

Cooperative activation of myosin by light chain phosphorylation in permeabilized smooth muscle

1992 • 113 citations

Modulation of hippocampal long-term potentiation and long-term depression by corticosteroid receptor activation

1994 • 101 citations

Pharmacological evidence for a role of long‐term potentiation in memory

1994 • 101 citations

Neurosteroids block Ca2+ channel current in freshly isolated hippocampal CA1 neurons

1991 • 98 citations

Exposure to a novel environment interferes with the induction of hippocampal primed burst potentiation in the behaving rat

1990 • 96 citations

Antidepressant and Cognition-Enhancing Effects of DHEA in Major Depression

1995 • 95 citations

Spatial memory and N-methyl-D-aspartate receptor antagonists APV and MK-801: Memory impairments depend on familiarity with the environment, drug dose, and training duration.

1994 • 93 citations

Modulation of long-term potentiation by peripherally administered amphetamine and epinephrine

1984 • 92 citations

Dehydroepiandrosterone (DHEA)‐the “Mother Steroid”

1994 • 91 citations

Dehydroepiandrosterone functions as more than an antiglucocorticoid in preserving immunocompetence after thermal injury.

1995 • 84 citations

DHEA-S selectively impairs contextual-fear conditioning: Support for the antiglucocorticoid hypothesis.

1997 • 76 citations

Type I adrenal steroid receptors prolong hippocampal long-term potentiation

1994 • 75 citations

The induction of corticosteroid actions on membrane properties of hippocampal CA1 neurons requires protein synthesis

1991 • 72 citations

Effects of Dehydroepiandrosterone Replacement in Elderly Men on Event-Related Potentials, Memory, and Well-Being

1998 • 67 citations

A Single Administration of Dehydroepiandrosterone Does Not Enhance Memory Performance in Young Healthy Adults, but Immediately Reduces Cortisol Levels

1997 • 65 citations

DHEAS as an Effective Vaccine Adjuvant in Elderly Humans

1995 • 60 citations

The neurosteroid dehydroepiandrosterone sulfate (DHEAS) enhances hippocampal primed burst, but not long-term, potentiation

1996 • 60 citations

Sensitization of the plasma corticosterone response to novel environments

1991 • 57 citations

Dehydroepiandrosterone prevents dexamethasone-induced hypertension in rats

1992 • 50 citations

Urethane anaesthesia and pituitary-adrenal function in the rat

1964 • 47 citations

Long-term potentiation: A good model for learning and memory?

1997 • 43 citations

Long-term control of neuronal excitability by corticosteroid hormones

1995 • 36 citations

The LTP–memory connection

1995 • 35 citations

The effect of urethane on pituitary-adrenal function of female rats

1984 • 31 citations

Effects of Dehydroepiandrosterone Sulfate and Stress on Hippocampal Electrophysiological Plasticity^a

1995 • 24 citations

Cholinergic Responsiveness of Rat CA1 Hippocampal NeuronsIn Vitro: Modulation by Corticosterone and Stress

1996 • 22 citations

Intracranial Dehydroepiandrosterone Blocks the Activation of Tryptophan Hydroxylase in Response to Acute Sound Stress

1994 • 17 citations

Wishing a dream came true: DHEA as a rejuvenating treatment?

1998 • 16 citations

A dose of MK801 previously shown to impair spatial learning in the radial maze attenuates primed burst potentiation in the dentate gyrus of freely moving rats.

1997 • 13 citations

Modulation of hippocampal primed burst potentiation by anesthesia

1990 • 12 citations

A dose of MK801 previously shown to impair spatial learning in the radial maze attenuates primed burst potentiation in the dentate gyrus of freely moving rats.

1997 • 11 citations