Spatial memory and N-methyl-D-aspartate receptor antagonists APV and MK-801: Memory impairments depend on familiarity with the environment, drug dose, and training duration.

The Hippocampus as a Cognitive Map

1978 • 8,087 citations

Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

1986 • 3,586 citations

Excitatory amino acids in synaptic transmission in the Schaffer collateral‐commissural pathway of the rat hippocampus.

1983 • 2,376 citations

Hippocampus, space, and memory

1979 • 2,033 citations

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.

1986 • 1,814 citations

Hippocampal synaptic enhancement and information storage within a distributed memory system

1987 • 1,291 citations

A triple dissociation of memory systems: Hippocampus, amygdala, and dorsal striatum.

2013 • 1,059 citations

Differential effects of fornix and caudate nucleus lesions on two radial maze tasks: evidence for multiple memory systems

1989 • 1,000 citations

Spatial memory and hippocampal function

1979 • 940 citations

The Primate Hippocampal Formation: Evidence for a Time-Limited Role in Memory Storage

1990 • 883 citations

Blocking of acquisition but not expression of conditioned fear-potentiated startle by NMDA antagonists in the amygdala

1990 • 806 citations

Synaptic plasticity and learning: selective impairment of learning rats and blockade of long-term potentiation in vivo by the N-methyl-D- aspartate receptor antagonist AP5

1989 • 766 citations

Two components of long-term potentiation induced by different patterns of afferent activation

1990 • 704 citations

Recognition impaired and association intact in the memory of monkeys after transection of the fornix.

1974 • 597 citations

The NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro

1992 • 545 citations

Long-term potentiation of guinea pig mossy fiber responses is not blocked by N-methyl d-aspartate antagonists

1986 • 545 citations

Spatial learning and memory processes: the search for their neurobiological mechanisms in the rat

1988 • 426 citations

Long-Term Synaptic Potentiation

1988 • 417 citations

Spatial memory and adaptive specialization of the hippocampus

1992 • 390 citations

Long-term potentiation of NMDA receptor-mediated synaptic transmission in the hippocampus

1991 • 370 citations

Spatial and object reversal learning in monkeys with partial temporal lobe ablations

1971 • 357 citations

Memory for spatial locations, motor responses, and objects: triple dissociation among the hippocampus, caudate nucleus, and extrastriate visual cortex

1993 • 331 citations

Hippocampectomy selectively disrupts discrimination reversal conditioning of the rabbit nictitating membrane response

1983 • 324 citations

Synaptic plasticity in fear conditioning circuits: induction of LTP in the lateral nucleus of the amygdala by stimulation of the medial geniculate body

1990 • 310 citations

The location and function of NMDA receptors in cat and kitten visual cortex

1989 • 310 citations

Effects of the NMDA antagonists CPP and MK-801 on radial arm maze performance in rats

1990 • 274 citations

Hippocampal place cells: stereotypy and plasticity

1989 • 262 citations

Long‐Term synaptic potentiation in the amygdala

1990 • 230 citations

Reversible inactivation of the medial septum differentially affects two forms of learning in rats

1990 • 212 citations

Further studies of hippocampal representation during odor discrimination learning.

1989 • 210 citations

Synapses, circuits, and the beginnings of memory

1986 • 201 citations

Effects of the NMDA receptor/channel antagonists CPP and MK801 on hippocampal field potentials and long-term potentiation in anesthetized rats

1988 • 198 citations

MK-801 blocks NMDA receptor-mediated synaptic transmission and long term potentiation in rat hippocampal slices

1987 • 194 citations

Behavioral effects of MK-801 mimic deficits associated with hippocampal damage

1989 • 190 citations

MK-801 and AP5 impair acquisition, but not retention, of the Morris milk maze

1990 • 176 citations

Differential Control by N‐Methyl‐D‐Aspartate and Kainate of Striatal Dopamine Release In Vivo: A Trans‐Striatal Dialysis Study

1988 • 175 citations

NMDA antagonist MK-801 impairs acquisition but not performance of spatial working and reference memory

1990 • 170 citations

Varieties of learning and memory in animals.

1993 • 164 citations

The NMDA receptor antagonist MK-801 prevents long-lasting non-associative morphine tolerance in the rat

1992 • 155 citations

Acquisition of a spatial conditioned place preference is impaired by amygdala lesions and improved by fornix lesions

1993 • 153 citations

Effects of intra-amygdala injections of NMDA receptor antagonists on acquisition and retention of inhibitory avoidance

1992 • 142 citations

Why NMDA-receptor-dependent long-term potentiation may not be a mechanism of learning and memory: Reappraisal of the NMDA-receptor blockade strategy

1990 • 129 citations

MK-801, phencyclidine (PCP), and PCP-like drugs increase burst firing in rat A10 dopamine neurons: Comparison to competitive NMDA antagonists

1993 • 122 citations

Long‐term potentiation of monosynaptic EPSPS in rat piroform cortex in vitro

1990 • 119 citations

Synaptic plasticity and learning II: Do different kinds of plasticity underlie different kinds of learning?

1989 • 118 citations

Induction of long‐term potentiation in the basolateral amygdala does not depend on NMDA receptor activation

1992 • 117 citations

Synaptic plasticity in visual cortex: comparison of theory with experiment

1991 • 117 citations

Hippocampal Function and Interference

1994 • 115 citations

Electrophysiological characteristics of cholinergic and non-cholinergic neurons in the rat medial septum-diagonal band complex

1990 • 105 citations

N-methyl-D-aspartate antagonists and working memory performance: Comparison with the effects of scopolamine, propranolol, diazepam, and phenylisopropyladenosine.

1991 • 104 citations

Hyperactivity, hyper-reactivity, and sensorimotor deficits induced by low doses of the N-methyl-d-aspartate non-competitive channel blocker MK801

1992 • 103 citations

Hippocampal Complex Spike Cells do not Change Their Place Fields if the Goal is Moved Within a Cue Controlled Environment

1990 • 98 citations

N-methyl-D-aspartate receptor antagonist MK-801 and spatial memory representation: Working memory is impaired in an unfamiliar but not in a familiar environment.

1992 • 96 citations

Effects of intrahippocampal injections of N-methyl-D-aspartate receptor antagonists and scopolamine on working and reference memory assessed in rats by a three-panel runway task.

1992 • 92 citations

GABAA responses in hippocampal neurons are potentiated by glutamate

1989 • 75 citations

Variations in Synaptic Plasticity and Types of Memory in Corticohippocampal Networks

1992 • 69 citations

Effects of intraventricular infusion of the N-methyl-d-aspartate (NMDA) receptor antagonist AP5 on spatial memory of rats in a radial arm maze

1992 • 65 citations

Synaptic transmission and recognition memory: Time course of changes in N-methyl-D-aspartate receptors after imprinting.

1991 • 64 citations

Activation of receptors contributes to the EPSP at perforant path synapses in the rat dentate gyrus in vitro

1989 • 46 citations

N-methyl-D-aspartate antagonist D-APV selectively disrupts taste-potentiated odor aversion learning.

1992 • 45 citations

Intracerebral distribution of DL-2-amino-phosphonopentanoic acid (AP5) and the dissociation of different types of learning

1991 • 41 citations

N-methyl-D-aspartate increases acetylcholine release from rat striatum and cortex: its effect is augmented by choline.

1992 • 40 citations

A simple network model simulates hippocampal place fields: II. Computing goal-directed trajectories and memory fields.

1993 • 39 citations

Complete transection of the fornix and reversal of position habit in the rat

1972 • 37 citations

The drug MK-801 attenuates the development, but not the expression, of long-term potentiation and stimulus train-induced bursting in hippocampal slices

1989 • 35 citations

The NMDA receptor-mediated components of responses evoked by patterned stimulation are not increased by long-term potentiation

1989 • 32 citations

Effects of the competitive NMDA antagonist CPP on performance of a place and cue radial maze task

1991 • 31 citations

Similar behavioural effects of sigma agonists and PCP-like non-competitive NMDA antagonists in guinea-pigs

1991 • 24 citations

The NMDA receptor concept: origins and development

1995 • 24 citations

MK-801 induced stereotypies in rats are decreased by haloperidol and increased by diazepam

1992 • 20 citations