The Structures of Telomeric DNA

Telomeres shorten during ageing of human fibroblasts

1990 • 5,530 citations

Principles of Nucleic Acid Structure

2008 • 4,570 citations

Identification of a specific telomere terminal transferase activity in tetrahymena extracts

1985 • 3,331 citations

A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes.

1988 • 2,281 citations

Formation of parallel four-stranded complexes by guanine-rich motifs in DNA and its implications for meiosis

1988 • 1,734 citations

A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis

1989 • 1,607 citations

Origin of Concatemeric T7DNA

1972 • 1,591 citations

THE STABILITY OF BROKEN ENDS OF CHROMOSOMES IN ZEA MAYS

1941 • 1,586 citations

The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats

1989 • 1,509 citations

HELIX FORMATION BY GUANYLIC ACID

1962 • 1,478 citations

Monovalent cation-induced structure of telomeric DNA: The G-quartet model

1989 • 1,202 citations

The telomere terminal transferase of tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity

1987 • 1,127 citations

The Discovery of Crown Ethers (Noble Lecture)

1988 • 1,047 citations

A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in Tetrahymena

1978 • 1,003 citations

Structure of yeast phenylalanine tRNA at 3 Å resolution

1974 • 1,000 citations

Telomeric DNA dimerizes by formation of guanine tetrads between hairpin loops

1989 • 939 citations

A mutant with a defect in telomere elongation leads to senescence in yeast

1989 • 905 citations

Crystal structure analysis of a complete turn of B-DNA

1980 • 844 citations

A sodium-potassium switch in the formation of four-stranded G4-DNA

1990 • 789 citations

THE MOLECULAR STRUCTURE OF CENTROMERES AND TELOMERES

1984 • 693 citations

Isolation of a higher eukaryotic telomere from Arabidopsis thaliana

1988 • 686 citations

Telomeric DNA oligonucleotides form novel intramolecular structures containing guanine·guanine base pairs

1987 • 675 citations

Purification and cloning of a DNA binding protein from yeast that binds to both silencer and activator elements

1987 • 637 citations

In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs

1990 • 632 citations

Cloning yeast telomeres on linear plasmid vectors

1982 • 625 citations

STRUCTURE AND FUNCTION OF TELOMERES

1989 • 604 citations

DNA sequences of telomeres maintained in yeast

1984 • 552 citations

Sugar and Disease

1972 • 532 citations

Two DNA-binding factors recognize specific sequences at silencers, upstream activating sequences, autonomously replicating sequences, and telomeres in Saccharomyces cerevisiae.

1988 • 511 citations

All gene-sized DNA molecules in four species of hypotrichs have the same terminal sequence and an unusual 3' terminus.

1981 • 477 citations

The remaking of chromosomes

1938 • 416 citations

Functional Evidence for an RNA Template in Telomerase

1990 • 392 citations

The guanosine binding site of the Tetrahymena ribozyme

1989 • 356 citations

X-ray fiber diffraction and model-building study of polyguanylic acid and polyinosinic acid

1975 • 339 citations

Magnesium ion-dependent triple-helix structure formed by homopurine-homopyrimidine sequences in supercoiled plasmid DNA.

1988 • 315 citations

Telomere proteins: Specific recognition and protection of the natural termini of Oxytricha macronuclear DNA

1986 • 305 citations

An overhanging 3' terminus is a conserved feature of telomeres.

1989 • 286 citations

Connections Between Transcriptional Activators, Silencers, and Telomeres as Revealed by Functional Analysis of a Yeast DNA-Binding Protein

1988 • 284 citations

The General Structure of Transfer RNA Molecules

1974 • 280 citations

Structures for polyinosinic acid and polyguanylic acid

1974 • 279 citations

Incompletely base-paired flip-flop terminal loops link the two DNA strands of the vaccinia virus genome into one uninterrupted polynucleotide chain

1982 • 279 citations

Telomeres, telomerase and senescence

1990 • 260 citations

Rolling hairpin model for replication of parvovirus and linear chromosomal DNA

1976 • 240 citations

Unusual DNA sequences associated with the ends of yeast chromosomes

1984 • 236 citations

Alkali metal ion specificity in the solution ordering of a nucleotide, 5'-guanosine monophosphate

1978 • 200 citations

Characterization of RNA hairpin loop stability

1988 • 197 citations

Nonempirical calculations on all the 29 possible DNA base pairs

1987 • 185 citations

RAP-1 factor is necessary for DNA loop formation in vitro at the silent mating type locus HML

1989 • 184 citations

Telomere terminal transferase activity in the hypotrichous ciliateOxytricha novaand a model for replication of the ends of linear DNA molecules

1988 • 171 citations

Recombination occurs during telomere formation in yeast

1989 • 169 citations

Cloning of human telomeres by complementation in yeast

1989 • 162 citations

Connections between transcriptional activators, silencers, and telomeres as revealed by functional analysis of a yeast DNA-binding protein.

1988 • 157 citations

Viable deletions of a telomere from a Drosophila chromosome

1989 • 151 citations

Molecular cloning of human telomeres in yeast

1989 • 147 citations

Telomere telomere recombination provides an express pathway for telomere acquisition

1990 • 146 citations

Chromosome ends in Drosophila without telomeric DNA sequences.

1990 • 139 citations

Chromatin structure of the molecular ends of oxytricha macronuclear DNA: phased nucleosomes and a telomeric complex

1984 • 139 citations

Hairpin formation in synthetic oligonucleotides

1985 • 130 citations

Telomere terminal transferase activity from Euplotes crassus adds large numbers of TTTTGGGG repeats onto telomeric primers.

1989 • 118 citations

Solid-state structural chemistry of lariat ether and BiBLE cation complexes: metal-ion identity and coordination number determine cavity size

1986 • 117 citations

Effect of monovalent cation-induced telomeric DNA structure on the binding of Oxytricha telomeric protein

1990 • 113 citations

Elaboration of telomeres in yeast: recognition and modification of termini from Oxytricha macronuclear DNA.

1984 • 113 citations

G-DNA: a twice-folded DNA structure adopted by single-stranded oligo(dG) and its implications for telomeres.

1990 • 110 citations

Structure of the 3′ hairpin termini of four rodent parvovirus genomes: Nucleotide sequence homology at origins of DNA replication

1979 • 107 citations

An irregular satellite sequence is found at the termini of the linear extrachromosomal rDNA in Dictyostelium discoideum

1981 • 107 citations

HYDROGEN-BONDED HELICAL CONFIGURATIONS OF POLYNUCLEOTIDES

1956 • 102 citations

Properties of the telomeric DNA-binding protein from Oxytricha nova

1989 • 96 citations

Proton, sodium-23, and phosphorus-31 NMR studies of the self-assembly of the 5'-guanosine monophosphate dianion in neutral aqueous solution in the presence of sodium cations

1980 • 94 citations

Telomeres and Their Synthesis

1990 • 93 citations

Higher order DNA structure in macronuclear chromatin of the hypotrichous ciliate Oxytricha nova.

1982 • 91 citations

A study of the structure of the lyomesophases formed by the dinucleoside phosphate d(GpG). An approach by x-ray diffraction and optical microscopy

1989 • 89 citations

X-ray study by fiber diffraction methods of a self-aggregate of guanosine-5′-phosphate with the same helical parameters as poly(rG)

1976 • 88 citations

Non-nucleosomal packaging of a tandemly repeated DNA sequence at termini of extrachromosomal DNA coding for rRNA in Tetrahymena.

1981 • 88 citations

Stable and metastable forms of poly(G)

1977 • 84 citations

Specific ring stacking interaction on the tryptophan-7-methylguanine system: comparative crystallographic studies of indole derivatives-7-methylguanine base, nucleoside, and nucleotide complexes

1988 • 83 citations

The cohering telomeres of Oxytricha

1987 • 81 citations

The structure of helical 5′-guanosine monophosphate

1975 • 81 citations

Poly(inosinic acid) helixes: essential chelation of alkali metal ions in the axial channel

1982 • 75 citations

Polynucleotides. V. Helix-Coil Transition of Polyriboguanylic Acid

1963 • 72 citations

Nucleoside conformations. X. An X-ray fiber diffraction study of the gels of guanine nucleosides.

1973 • 72 citations

Two versions of the gene encoding the 41-kilodalton subunit of the telomere binding protein of Oxytricha nova.

1990 • 66 citations

An unusual DMA structure detected in a telomeric sequence under superhelical stress and at low pH

1989 • 65 citations

Atomic-resolution structure of the cellulose synthase regulator cyclic diguanylic acid.

1990 • 60 citations

Assembly and self-association of Oxytricha telomeric nucleoprotein complexes

1989 • 58 citations

Structure-directing properties of sodium(+) ion in the solution ordering of guanosine 5'-monophosphate. Stoichiometry of aggregation, binding to ethidium, and modes of sodium(+) ion complexation

1982 • 58 citations

In vitro aggregation of the gene-sized DNA molecules of the ciliate Stylonychia mytilus.

1980 • 58 citations

How does the end begin?

1990 • 57 citations

Telomere G-strand structure and function analyzed by chemical protection, base analog substitution, and utilization by telomerase in vitro

1990 • 55 citations

Oxytrichatelomeric nucleoprotein complexes reconstituted with synthetic DNA

1989 • 50 citations

Eukaryotic nuclear telomeres: Molecular fossils of the RNP world?

1988 • 46 citations

Magnesium-dependent supercoiling-induced transition in (dG)_n·(dC)_nstretches and formation of a new G-structure by (dG)_nstrand

1989 • 43 citations

Base stacking in nucleic acid components: The crystal structures of guanine, guanosine and inosine

1968 • 41 citations

Structure of the extrachromosomal ribosomal RNA chromatin of Physarum polycephalum

1987 • 40 citations

DNA primase and the replication of the telomeres inOxytricha nova

1989 • 38 citations

Poly(I) helix formation. Dependence on size-specific complexing to alkali metal ions

1978 • 35 citations

S1 nuclease sensitivity of a double-stranded telomeric DNA sequence

1987 • 34 citations

Site-specific phasing in the chromatin of the rDNA in Dictyostelium discoideum

1984 • 33 citations

Host-guest complexation. 38. Cryptahemispherands and their complexes.

1986 • 31 citations

Host-guest complexation-37

1986 • 29 citations

Sequences of three closely related variants of a complex satellite DNA diverge at specific domains.

1985 • 27 citations

The turn of the quadruplex?

1989 • 21 citations

Copy editing — what's the U's?

1990 • 5 citations