Pharmacoresistance in Epilepsy: A Pilot PET Study with the P‐Glycoprotein Substrate R‐[11C]verapamil

Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

2000 • 2,358 citations

Graphical Analysis of Reversible Radioligand Binding from Time—Activity Measurements Applied to [N-¹¹C-Methyl]-(−)-Cocaine PET Studies in Human Subjects

1990 • 1,412 citations

Three‐dimensional maximum probability atlas of the human brain, with particular reference to the temporal lobe

2003 • 1,156 citations

Blood-brain barrier active efflux transporters: ATP-binding cassette gene family

2004 • 789 citations

Blood–brain barrier dysfunction in parkinsonian midbrain in vivo

2005 • 681 citations

Association of Multidrug Resistance in Epilepsy with a Polymorphism in the Drug-Transporter GeneABCB1

2003 • 653 citations

Choroid plexus epithelial expression of MDR 1 P glycoprotein and multidrug resistance-associated protein contribute to the blood–cerebrospinal-fluid drug-permeability barrier

1999 • 529 citations

MDR1 Gene Expression in Brain of Patients with Medically Intractable Epilepsy

1995 • 525 citations

Overexpression of Multiple Drug Resistance Genes in Endothelial Cells from Patients with Refractory Epilepsy

2001 • 432 citations

Role of Multidrug Transporters in Pharmacoresistance to Antiepileptic Drugs

2002 • 409 citations

Molecular and cellular mechanisms of pharmacoresistance in epilepsy

2005 • 397 citations

Imaging P-glycoprotein transport activity at the human blood-brain barrier with positron emission tomography

2005 • 268 citations

Multidrug Resistance Protein MRP2 Contributes to Blood-Brain Barrier Function and Restricts Antiepileptic Drug Activity

2003 • 232 citations

Failure to confirm association of a polymorphism in ABCB1 with multidrug-resistant epilepsy

2004 • 211 citations

P-glycoprotein and multidrug resistance-associated protein are involved in the regulation of extracellular levels of the major antiepileptic drug carbamazepine in the brain

2001 • 201 citations

Characterization of the major metabolites of verapamil as substrates and inhibitors of P-glycoprotein.

2000 • 200 citations

Expression and Cellular Distribution of Multidrug Resistance–related Proteins in the Hippocampus of Patients with Mesial Temporal Lobe Epilepsy

2004 • 195 citations

Lack of Association between the C3435T Polymorphism in the Human Multidrug Resistance (MDR1) Gene and Response to Antiepileptic Drug Treatment

2005 • 194 citations

In Vivo Evidence for P‐Glycoprotein–Mediated Transport of Phenytoin at the Blood–Brain Barrier of Rats

2001 • 185 citations

Complete in vivo reversal of P‐glycoprotein pump function in the blood‐brain barrier visualized with positron emission tomography

1998 • 182 citations

Effect of age on functional P-glycoprotein in the blood-brain barrier measured by use of (R)-[11C]verapamil and positron emission tomography

2006 • 174 citations

Association of an ABCB1 gene haplotype with pharmacoresistance in temporal lobe epilepsy

2004 • 171 citations

Valproic Acid Is Not a Substrate for P-glycoprotein or Multidrug Resistance Proteins 1 and 2 in a Number of in Vitro and in Vivo Transport Assays

2006 • 156 citations

Comparison of Brain Extracellular Fluid, Brain Tissue, Cerebrospinal Fluid, and Serum Concentrations of Antiepileptic Drugs Measured Intraoperatively in Patients with Intractable Epilepsy

2006 • 155 citations

Tracer Kinetics in Biomedical Research: From Data to Model

2013 • 151 citations

Carbamazepine is not a substrate for P‐glycoprotein

2001 • 142 citations

Over-expression of Pglycoprotein in malformations of cortical development

1999 • 118 citations

Evaluation of (R)-[11C]verapamil as PET tracer of P-glycoprotein function in the blood–brain barrier: kinetics and metabolism in the rat

2005 • 110 citations

Carbon-11-labeled daunorubicin and verapamil for probing P-glycoprotein in tumors with PET.

1996 • 98 citations

Evaluation of Tracer Kinetic Models for Quantification of P-Glycoprotein Function using (R)-[¹¹C]Verapamil and PET

2006 • 91 citations

Inhibition of multidrug transporters by verapamil or probenecid does not alter blood-brain barrier penetration of levetiracetam in rats

2004 • 88 citations

In Vivo Evaluation of P-glycoprotein Function at the Blood-Brain Barrier in Nonhuman Primates Using [¹¹C]Verapamil

2005 • 85 citations

Kinetic modeling of [¹⁸F]FDG in skeletal muscle by PET: a four-compartment five-rate-constant model

2001 • 83 citations

Reversal of Multidrug Resistance: Lessons from Clinical Oncology

2002 • 78 citations

Localization of Multidrug Transporter Substrates within Model Membranes

2006 • 78 citations

Influence of functional haplotypes in the drug transporter gene on central nervous system drug distribution in humans

2005 • 68 citations

Pharmacokinetic Consequences of Active Drug Efflux at the Blood–Brain Barrier

2006 • 62 citations

Duration and degree of cyclosporin induced P-glycoprotein inhibition in the rat blood–brain barrier can be studied with PET

2006 • 56 citations

How to Explain Multidrug Resistance in Epilepsy?

2005 • 54 citations

Quantitative analysis of 11C-verapamil transfer at the human blood-brain barrier for evaluation of P-glycoprotein function.

2006 • 41 citations

Simultaneous analysis of MDR1 C3435T, G2677T/A, and C1236T genotypes by multiplexed mutagenically separated PCR

2005 • 12 citations

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