Back to search

In Vivo Evaluation of P-glycoprotein Function at the Blood-Brain Barrier in Nonhuman Primates Using [11C]Verapamil

Data up to Jan 2025

Published2005
Citations85
References35

Total Citations Per Year

Abstract

References (35)

FINE STRUCTURAL LOCALIZATION OF A BLOOD-BRAIN BARRIER TO EXOGENOUS PEROXIDASE

1967 • 2,534 citations

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1994 • 2,255 citations

Blood–brain barrier dysfunction in parkinsonian midbrain in vivo

2005 • 681 citations

Association of Multidrug Resistance in Epilepsy with a Polymorphism in the Drug-Transporter GeneABCB1

2003 • 653 citations

Increased drug delivery to the brain by P-glycoprotein inhibition

2000 • 422 citations

β‐Amyloid efflux mediated by p‐glycoprotein

2001 • 368 citations

Transporter-Mediated Permeation of Drugs Across the Blood–Brain Barrier

2000 • 361 citations

Deposition of Alzheimer's ??-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans

2002 • 331 citations

Imaging P-glycoprotein transport activity at the human blood-brain barrier with positron emission tomography

2005 • 268 citations

A high resolution animal PET scanner using compact PS-PMT detectors

1997 • 241 citations

Recent Advances in Blood-Brain Barrier Transport

1988 • 230 citations

Functional Brain Mapping of Monkey Tool Use

2001 • 215 citations

Failure to confirm association of a polymorphism in ABCB1 with multidrug-resistant epilepsy

2004 • 211 citations

Characterization of the major metabolites of verapamil as substrates and inhibitors of P-glycoprotein.

2000 • 200 citations

Identification of P450 enzymes involved in metabolism of verapamil in humans

1993 • 200 citations

Development of anIn SituMouse Brain Perfusion Model and its Application tomdr1aP-Glycoprotein-Deficient Mice

2000 • 196 citations

Complete in vivo reversal of P‐glycoprotein pump function in the blood‐brain barrier visualized with positron emission tomography

1998 • 182 citations

Efflux transport systems for drugs at the blood–brain barrier and blood–cerebrospinal fluid barrier (Part 1)

2001 • 173 citations

PET Studies on P-Glycoprotein Function in the Blood-Brain Barrier: How it Affects Uptake and Binding of Drugs within the CNS

2004 • 147 citations

P-Glycoprotein mediates the efflux of quinidine across the blood-brain barrier.

1997 • 140 citations

A new in vivo method to study P-glycoprotein transport in tumors and the blood-brain barrier.

1999 • 135 citations

Expression of mRNAs of multidrug resistance proteins (Mrps) in cultured rat astrocytes, oligodendrocytes, microglial cells and neurones

2002 • 133 citations

In vivo determination of cerebral blood volume with radioactive oxygen-15 in the monkey.

1975 • 91 citations

A review of graphical methods for tracer studies and strategies to reduce bias

2003 • 91 citations

Determination of in vivo absorption, metabolism, and transport of drugs by the human intestinal wall and liver with a novel perfusion technique

2001 • 90 citations

Quantitative assessment of P-glycoprotein function in the rat blood–brain barrier by distribution volume of [11C]verapamil measured with PET

2003 • 81 citations

Kinetic Analysis of In Vivo Receptor-Dependent Binding of Human Epidermal Growth Factor by Rat Tissues

1988 • 76 citations

Effect of P-glycoprotein inhibition on methadone analgesia and brain distribution in the rat

2004 • 73 citations

Sensitive measurement of positron emitters eluted from HPLC

2001 • 73 citations

Effect of PSC 833, a P-glycoprotein modulator, on the disposition of vincristine and digoxin in rats.

1999 • 70 citations

In vivo binding properties of [carbonyl‐11C]WAY‐100635: Effect of endogenous serotonin

2001 • 64 citations

Rapid and highly sensitive method for the determination of verapamil, [2H7]verapamil and metabolites in biological fluids by liquid chromatography–mass spectrometry

2000 • 45 citations

An improved method for the preparation of [11C]verapamil

2002 • 34 citations

Effect of PSC 833 liposomes and Intralipid on the transport of epirubicin in Caco-2 cells and rat intestines

2001 • 25 citations

Selective inhibition of human cytochrome P450 3A4 by N-[2(R)-hydroxy-1(S)-indanyl]-5-[2(S)-(1, 1-dimethylethylaminocarbonyl)-4-[(furo[2, 3-b]pyridin-5-yl)methyl]piperazin-1-yl]-4(S)-hydroxy-2(R)-phenylmethy lpentanamide and P-glycoprotein by valspodar in gene transfectant systems.

2000 • 23 citations

Cited By (0)

Loading...
In Vivo Evaluation of P-glycoprotein Function at the Blood-Brain Barrier in Nonhuman… (2005) – Journal of Pharmacology and Experimental Therapeutics | Metascience Observatory Explorer