In Vivo Evaluation of P-glycoprotein Function at the Blood-Brain Barrier in Nonhuman Primates Using [11C]Verapamil
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References (35)
FINE STRUCTURAL LOCALIZATION OF A BLOOD-BRAIN BARRIER TO EXOGENOUS PEROXIDASE
1967 • 2,534 citations
Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
1994 • 2,255 citations
Blood–brain barrier dysfunction in parkinsonian midbrain in vivo
2005 • 681 citations
Association of Multidrug Resistance in Epilepsy with a Polymorphism in the Drug-Transporter GeneABCB1
2003 • 653 citations
Increased drug delivery to the brain by P-glycoprotein inhibition
2000 • 422 citations
β‐Amyloid efflux mediated by p‐glycoprotein
2001 • 368 citations
Transporter-Mediated Permeation of Drugs Across the Blood–Brain Barrier
2000 • 361 citations
Deposition of Alzheimer's ??-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans
2002 • 331 citations
Imaging P-glycoprotein transport activity at the human blood-brain barrier with positron emission tomography
2005 • 268 citations
A high resolution animal PET scanner using compact PS-PMT detectors
1997 • 241 citations
Recent Advances in Blood-Brain Barrier Transport
1988 • 230 citations
Functional Brain Mapping of Monkey Tool Use
2001 • 215 citations
Failure to confirm association of a polymorphism in ABCB1 with multidrug-resistant epilepsy
2004 • 211 citations
Characterization of the major metabolites of verapamil as substrates and inhibitors of P-glycoprotein.
2000 • 200 citations
Identification of P450 enzymes involved in metabolism of verapamil in humans
1993 • 200 citations
Development of anIn SituMouse Brain Perfusion Model and its Application tomdr1aP-Glycoprotein-Deficient Mice
2000 • 196 citations
Complete in vivo reversal of P‐glycoprotein pump function in the blood‐brain barrier visualized with positron emission tomography
1998 • 182 citations
Efflux transport systems for drugs at the blood–brain barrier and blood–cerebrospinal fluid barrier (Part 1)
2001 • 173 citations
PET Studies on P-Glycoprotein Function in the Blood-Brain Barrier: How it Affects Uptake and Binding of Drugs within the CNS
2004 • 147 citations
P-Glycoprotein mediates the efflux of quinidine across the blood-brain barrier.
1997 • 140 citations
A new in vivo method to study P-glycoprotein transport in tumors and the blood-brain barrier.
1999 • 135 citations
Expression of mRNAs of multidrug resistance proteins (Mrps) in cultured rat astrocytes, oligodendrocytes, microglial cells and neurones
2002 • 133 citations
In vivo determination of cerebral blood volume with radioactive oxygen-15 in the monkey.
1975 • 91 citations
A review of graphical methods for tracer studies and strategies to reduce bias
2003 • 91 citations
Determination of in vivo absorption, metabolism, and transport of drugs by the human intestinal wall and liver with a novel perfusion technique
2001 • 90 citations
Quantitative assessment of P-glycoprotein function in the rat blood–brain barrier by distribution volume of [11C]verapamil measured with PET
2003 • 81 citations
Kinetic Analysis of In Vivo Receptor-Dependent Binding of Human Epidermal Growth Factor by Rat Tissues
1988 • 76 citations
Effect of P-glycoprotein inhibition on methadone analgesia and brain distribution in the rat
2004 • 73 citations
Sensitive measurement of positron emitters eluted from HPLC
2001 • 73 citations
Effect of PSC 833, a P-glycoprotein modulator, on the disposition of vincristine and digoxin in rats.
1999 • 70 citations
In vivo binding properties of [carbonyl‐11C]WAY‐100635: Effect of endogenous serotonin
2001 • 64 citations
Rapid and highly sensitive method for the determination of verapamil, [2H7]verapamil and metabolites in biological fluids by liquid chromatography–mass spectrometry
2000 • 45 citations
An improved method for the preparation of [11C]verapamil
2002 • 34 citations
Effect of PSC 833 liposomes and Intralipid on the transport of epirubicin in Caco-2 cells and rat intestines
2001 • 25 citations
Selective inhibition of human cytochrome P450 3A4 by N-[2(R)-hydroxy-1(S)-indanyl]-5-[2(S)-(1, 1-dimethylethylaminocarbonyl)-4-[(furo[2, 3-b]pyridin-5-yl)methyl]piperazin-1-yl]-4(S)-hydroxy-2(R)-phenylmethy lpentanamide and P-glycoprotein by valspodar in gene transfectant systems.
2000 • 23 citations