A Conserved Sequence within the Propeptide Domain of Membrane Type 1 Matrix Metalloproteinase Is Critical for Function as an Intramolecular Chaperone

Matrix Metalloproteinases

1999 • 3,774 citations

Matrix Metalloproteinases: A Review

1993 • 2,998 citations

A matrix metalloproteinase expressed on the surface of invasive tumour cells

1994 • 2,561 citations

High-Resolution Epitope Mapping of hGH-Receptor Interactions by Alanine-Scanning Mutagenesis

1989 • 1,357 citations

Matrix metalloproteinases: effectors of development and normal physiology

2000 • 1,236 citations

Matrix metalloproteinases: structures, evolution, and diversification

1998 • 759 citations

Membrane-Type 1 Matrix Metalloproteinase Cleaves Cd44 and Promotes Cell Migration

2001 • 732 citations

Matrix Metalloproteinases Regulate Neovascularization by Acting as Pericellular Fibrinolysins

1998 • 716 citations

Multiple modes of activation of latent human fibroblast collagenase: evidence for the role of a Cys73 active-site zinc complex in latency and a "cysteine switch" mechanism for activation.

1990 • 699 citations

Role of Cell Surface Metalloprotease Mt1-Mmp in Epithelial Cell Migration over Laminin-5

2000 • 650 citations

Regulation of Cell Invasion and Morphogenesis in a Three-Dimensional Type I Collagen Matrix by Membrane-Type Matrix Metalloproteinases 1, 2, and 3

2000 • 588 citations

The TIMP2 Membrane Type 1 Metalloproteinase “Receptor” Regulates the Concentration and Efficient Activation of Progelatinase A

1998 • 578 citations

Proteolytic exposure of a cryptic site within collagen type IV is required for angiogenesis and tumor growth in vivo

2001 • 475 citations

Membrane‐Type Matrix Metalloproteinases 1 and 2 Exhibit Broad‐Spectrum Proteolytic Capacities Comparable to Many Matrix Metalloproteinases

1997 • 434 citations

Transmembrane/cytoplasmic domain-mediated membrane type 1-matrix metalloprotease docking to invadopodia is required for cell invasion

1997 • 419 citations

Transmembrane-deletion Mutants of the Membrane-type Matrix Metalloproteinase-1 Process Progelatinase A and Express Intrinsic Matrix-degrading Activity

1996 • 392 citations

Crystal structure of the complex formed by the membrane type 1-matrix metalloproteinase with the tissue inhibitor of metalloproteinases-2, the soluble progelatinase A receptor

1998 • 360 citations

Regulation of Membrane Type-1 Matrix Metalloproteinase Activation by Proprotein Convertases

2000 • 307 citations

Membrane‐type matrix metalloproteinases

1999 • 303 citations

Tissue Inhibitor of Metalloproteinase-2 (TIMP-2) Binds to the Catalytic Domain of the Cell Surface Receptor, Membrane Type 1-Matrix Metalloproteinase 1 (MT1-MMP)

1998 • 285 citations

The C-terminal Region of Membrane Type Matrix Metalloproteinase Is a Functional Transmembrane Domain Required for Pro-gelatinase A Activation

1995 • 269 citations

Structural features of a superfamily of zinc-endopeptidases: the metzincins

1995 • 236 citations

Matrix-dependent Proteolysis of Surface Transglutaminase by Membrane-type Metalloproteinase Regulates Cancer Cell Adhesion and Locomotion

2001 • 235 citations

Regulation of the α‐secretase ADAM10 by its prodomain and proprotein convertases

2001 • 232 citations

The activation of ProMMP-2 (gelatinase A) by HT1080 fibrosarcoma cells is promoted by culture on a fibronectin substrate and is concomitant with an increase in processing of MT1-MMP (MMP-14) to a 45 kDa form

1998 • 228 citations

Proteolytic processing of membrane-type-1 matrix metalloproteinase is associated with gelatinase A activation at the cell surface

1998 • 223 citations

Detergent-activation of latent collagenase and resolution of its component molecules

1982 • 202 citations

Regulation of Membrane-type-1 Matrix Metalloproteinase Activity by Its Cytoplasmic Domain

2000 • 164 citations

Mutation Analysis of Membrane Type-1 Matrix Metalloproteinase (MT1-MMP)

2001 • 158 citations

Functional activation of integrin ?v?3 in tumor cells expressing membrane-type 1 matrix metalloproteinase

2000 • 156 citations

Protein memory through altered folding mediated by intramolecular chaperones

1997 • 145 citations

Structural analysis and promoter characterization of the human membrane-type matrix metalloproteinase-1 (MT1-MMP) gene

2000 • 142 citations

Tissue Inhibitor of Metalloproteinase (TIMP)-2 Acts Synergistically with Synthetic Matrix Metalloproteinase (MMP) Inhibitors but Not with TIMP-4 to Enhance the (Membrane Type 1)-MMP-dependent Activation of Pro-MMP-2

2000 • 135 citations

Membrane Type Matrix Metalloproteinase 1 Activates Pro-gelatinase A without Furin Cleavage of the N-terminal Domain

1996 • 114 citations

Mutational analysis of the transin (rat stromelysin) autoinhibitor region demonstrates a role for residues surrounding the “cysteine switch”

1991 • 99 citations

Roles of membrane type 1 matrix metalloproteinase and tissue inhibitor of metalloproteinases 2 in invasion and dissemination of human malignant glioma

2001 • 91 citations

The Propeptide Domain of Membrane Type 1 Matrix Metalloproteinase Is Required for Binding of Tissue Inhibitor of Metalloproteinases and for Activation of Pro-gelatinase A

1998 • 85 citations

Folding Pathway Mediated by an Intramolecular Chaperone

2000 • 78 citations

Enhanced production and activation of progelatinase A mediated by membrane-type 1 matrix metalloproteinase in human oral squamous cell carcinomas: implications for lymph node metastasis.

2000 • 71 citations

Cell Migration through Extracellular Matrix

2000 • 70 citations

Mutation of the Active Site Glutamic Acid of Human Gelatinase A: Effects on Latency, Catalysis, and the Binding of Tissue Inhibitor of Metalloproteinases-1

1994 • 67 citations

APMA (4-Aminophenylmercuric Acetate) Activation of Stromelysin-1 Involves Protein Interactions in Addition to Those with Cysteine-75 in the Propeptide

1996 • 64 citations

Roles of the Propeptide and Metal Ions in the Folding and Stability of the Catalytic Domain of Stromelysin (Matrix Metalloproteinase 3)

1996 • 56 citations

Furin-independent Pathway of Membrane Type 1-Matrix Metalloproteinase Activation in Rabbit Dermal Fibroblasts

1999 • 54 citations

Interaction with Heparin and Matrix Metalloproteinase 2 Cleavage Expose a Cryptic Anti-adhesive Site of Fibronectin

2000 • 53 citations

Pro Region C-Terminus:Protease Active Site Interactions Are Critical in Catalyzing the Folding of α-Lytic Protease

1998 • 47 citations

The Propeptide Domain of Membrane Type 1-Matrix Metalloproteinase Acts as an Intramolecular Chaperone when Expressed in transwith the Mature Sequence in COS-1 Cells

2000 • 45 citations

The Function of Propeptide Domains of Cysteine Proteinases

2006 • 39 citations

The Residual Pro-Part of Cathepsin C Fulfills the Criteria Required for an Intramolecular Chaperone in Folding and Stabilizing the Human Proenzyme

2000 • 33 citations

Multiple sites of the propeptide region of human stromelysin-1 are required for maintaining a latent form of the enzyme.

1994 • 31 citations