Inhibition of matrix metalloproteinases by over‐expression of tissue inhibitor of metalloproteinase‐2 inhibits the growth of experimental hemangiomas

Changing views of the role of matrix metalloproteinases in metastasis

1997 • 1,585 citations

ECM and Cell Surface Proteolysis: Regulating Cellular Ecology

1997 • 1,311 citations

Angiostatin induces and sustains dormancy of human primary tumors in mice

1996 • 1,193 citations

Matrix metalloproteinases in angiogenesis: a moving target for therapeutic intervention

1999 • 840 citations

Matrix Metalloproteinases Regulate Neovascularization by Acting as Pericellular Fibrinolysins

1998 • 716 citations

Cellular markers that distinguish the phases of hemangioma during infancy and childhood.

1994 • 651 citations

Divergent effects of tissue inhibitor of metalloproteinase-1, -2, or -3 overexpression on rat vascular smooth muscle cell invasion, proliferation, and death in vitro. TIMP-3 promotes apoptosis.

1998 • 468 citations

Requirement for Specific Proteases in Cancer Cell Intravasation as Revealed by a Novel Semiquantitative PCR-Based Assay

1998 • 459 citations

Increased proteolytic activity is responsible for the aberrant morphogenetic behavior of endothelial cells expressing the middle T oncogene

1990 • 452 citations

Contributions of tumor and stromal matrix metalloproteinases to tumor progression, invasion and metastasis

1995 • 429 citations

Inhibition of invasion and metastasis in cells transfected with an inhibitor of metalloproteinases.

1992 • 429 citations

Tissue inhibitor of metalloproteinases‐2 inhibits bFGF‐induced human microvascular endothelial cell proliferation

1993 • 362 citations

Tumor Cell Invasion Inhibited by TIMP-2

1991 • 324 citations

Proteases as prognostic markers in cancer.

1996 • 319 citations

Inhibition of invasion and induction of apoptotic cell death of cancer cell lines by overexpression of TIMP-3

1999 • 285 citations

TIMP-2 over-expression reduces invasion and angiogenesis and protects B16F10 melanoma cells from apoptosis

1998 • 274 citations

Embryonic lethalities and endothelial tumors in chimeric mice expressing polyoma virus middle T oncogene

1988 • 255 citations

Endothelioma cells expressing the polyoma middle T oncogene induce hemangiomas by host cell recruitment

1989 • 252 citations

Inhibition of osteolytic bone metastasis of breast cancer by combined treatment with the bisphosphonate ibandronate and tissue inhibitor of the matrix metalloproteinase-2.

1997 • 250 citations

Inhibition of Angiogenesis and Murine Hemangioma Growth by Batimastat, a Synthetic Inhibitor of Matrix Metalloproteinases

1995 • 234 citations

Matrix metalloproteinases as stromal effectors of human carcinoma progression: Therapeutic implications

1997 • 207 citations

Tumor and stromal expression of matrix metalloproteinases and their role in tumor progression.

1994 • 200 citations

Tissue inhibitor of metalloproteinase‐2 (TIMP‐2) has erythroid‐potentiating activity

1992 • 200 citations

Effect of tissue inhibitor of the matrix metalloproteinases-2 expression on the growth and spontaneous metastasis of a human melanoma cell line.

1994 • 168 citations

Progressive growth in immunodeficient mice and host cell recruitment by mouse endothelial cells transformed by polyoma middle-sized T antigen: implications for the pathogenesis of opportunistic vascular tumors.

1994 • 168 citations

Induction of angiogenesis in chick yolk-sac membrane by polyamines and its inhibition by tissue inhibitors of metalloproteinases (TIMP and TIMP-2)

1990 • 154 citations

Angiogenic potential in vivo by Kaposiʼs sarcoma cell-free supernatants and HIV-1 tat product: inhibition of KS-like lesions by tissue inhibitor of metalloproteinase-2

1994 • 154 citations

Immunohistochemical localization of matrix metallloproteinase 2 and its specific inhibitor timp‐2 in neoplastic tissues with monclonal antibodies

1994 • 137 citations

Overexpression of tissue inhibitor of metalloproteinases-2 retroviral-mediated gene transfer in vivo inhibits tumor growth and invasion.

1996 • 134 citations

Proteases and Protease Inhibitors in Tumor Progression

1997 • 124 citations

BAY 12-9566, a novel inhibitor of matrix metalloproteinases with antiangiogenic activity.

1999 • 106 citations

Tissue inhibitor of metalloproteinase-2 stimulates mesenchymal growth and regulates epithelial branching during morphogenesis of the rat metanephros

1999 • 106 citations

TIMP-2 Growth-Stimulatory Activity: A Concentration- and Cell Type-Specific Response in the Presence of Insulin

1996 • 86 citations

Posttranscriptional Stimulation of Endothelial Cell Matrix Metalloproteinases 2 and 1 by Endothelioma Cells

2000 • 48 citations

Endothelial cell migration and invasiveness are induced by a soluble factor produced by murine endothelioma cells transformed by polyoma virus middle T oncogene.

1993 • 30 citations

TIMP‐2 Expression Modulates Human Melanoma Cell Adhesion and Motility

1994 • 26 citations