Homology between phenylalanine and tyrosine hydroxylases reveals common structural and functional domains

A general method applicable to the search for similarities in the amino acid sequence of two proteins

1970 • 11,049 citations

Why genes in pieces?

1978 • 2,256 citations

[47] Establishing homologies in protein sequences

1983 • 1,187 citations

Complete coding sequence of rat tyrosine hydroxylase mRNA.

1985 • 544 citations

Hydroxylation-Induced Migration: The NIH Shift

1967 • 519 citations

Cloned human phenylalanine hydroxylase gene allows prenatal diagnosis and carrier detection of classical phenylketonuria

1983 • 334 citations

Nucleotide sequence of a full-length complementary DNA clone and amino acid sequence of human phenylalanine hydroxylase

1985 • 325 citations

Phosphorylation of tyrosine hydroxylase by calmodulin-dependent multiprotein kinase.

1984 • 152 citations

In vitro activation of rat liver phenylalanine hydroxylase by phosphorylation.

1976 • 149 citations

The Stimulation of Rat Liver Phenylalanine Hydroxylase by Lysolecithin and α-Chymotrypsin

1973 • 143 citations

Gene Transfer and Expression of Human Phenylalanine Hydroxylase

1985 • 131 citations

Identification of cDNA clones coding for rat tyrosine hydroxylase antigen.

1982 • 94 citations

Bovine adrenal tyrosine hydroxylase: purification and properties.

1977 • 92 citations

Specificity of amino acids as activators and substrates for phenylalanine hydroxylase.

1982 • 83 citations

The Stimulation of Rat Liver Phenylalanine Hydroxylase by Phospholipids

1972 • 82 citations

Intron-dependent evolution of chicken glyceraldehyde phosphate dehydrogenase gene

1985 • 75 citations

The activation of rat liver phenylalanine hydroxylase by limited proteolysis, lysolecithin, and tocopherol phosphate. Changes in conformation and catalytic properties.

1984 • 75 citations

Bovine Adrenal Tyrosine Hydroxylase: Comparative Study of Native and Proteolyzed Enzyme, and Their Interaction with Anions

1981 • 74 citations

The isolation and properties of phenylalanine hydroxylase from rat liver

1974 • 69 citations

Rat liver phenylalanine hydroxylase. Activation by sulfhydryl modification.

1981 • 68 citations

Amino acid sequence at the phosphorylated site of rat liver phenylalanine hydroxylase and phosphorylation of a corresponding synthetic peptide

1980 • 60 citations

Evidence for the Existence of Homologous Gene Coding Regions for the Catecholamine Biosynthetic Enzymes

1983 • 49 citations

Analysis of large nucleic acid dot matrices on small computers

1984 • 44 citations

Two apparent molecular weight forms of human and monkey phenylalanine hydroxylase are due to phosphorylation.

1984 • 42 citations

Production of antibodies to rat liver phenylalanine hydroxylase. Cross-reactivity with other pterin-dependent hydroxylases.

1972 • 35 citations

Sequence comparison of rat liver phenylalanine hydroxylase and its cDNA clones

1984 • 32 citations

Distribution of phenylalanine hydroxylase (EC 1.14.3.1) in liver and kidney of vertebrates

1979 • 30 citations

Some characteristics of partially purified human liver phenylalanine hydroxylase

1973 • 28 citations

The Tryptophan Hydroxylase of Chromobacterium violaceum

1974 • 24 citations

Cloning and Characterization of Rat-brain-specific Transcripts: Rare, Brain-specific Transcripts and Tyrosine Hydroxylase

1983 • 23 citations

Phenylalanine hydroxylase from Pseudomonas sp. (ATCC 11299a). Purification, molecular weight, and influence of tyrosine metabolites on activation and hydroxylation.

1975 • 20 citations