Ultraviolet Radiation Triggers the Ribotoxic Stress Response in Mammalian Cells

DNA Repair and Mutagenesis

2006 • 4,725 citations

The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation

1991 • 3,396 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

DNA repair and mutagenesis

1996 • 2,289 citations

Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine

1995 • 2,238 citations

Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms

1995 • 1,562 citations

The mechanism of action of ricin and related toxic lectins on eukaryotic ribosomes. The site and the characteristics of the modification in 28 S ribosomal RNA caused by the toxins.

1987 • 1,153 citations

A Divergence in the MAP Kinase Regulatory Network Defined by MEK Kinase and Raf

1993 • 1,086 citations

Ultraviolet Light and Osmotic Stress: Activation of the JNK Cascade Through Multiple Growth Factor and Cytokine Receptors

1996 • 1,046 citations

Identification of a Dual Specificity Kinase That Activates the Jun Kinases and p38-Mpk2

1995 • 775 citations

Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1

1994 • 706 citations

Ternary complex factors: growth factor regulated transcriptional activators

1994 • 686 citations

NF-kappa B activation by ultraviolet light not dependent on a nuclear signal

1993 • 646 citations

An Osmosensing Signal Transduction Pathway in Mammalian Cells

1994 • 584 citations

Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast

1995 • 578 citations

UV-induced DNA damage is an intermediate step in UV-induced expression of human immunodeficiency virus type 1, collagenase, c-fos, and metallothionein.

1989 • 549 citations

Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents.

1996 • 523 citations

Ribosomes as sensors of heat and cold shock in Escherichia coli.

1990 • 516 citations

The Ribosome : structure, function, and evolution

1990 • 508 citations

Ribotoxic Stress Response: Activation of the Stress-Activated Protein Kinase JNK1 by Inhibitors of the Peptidyl Transferase Reaction and by Sequence-Specific RNA Damage to the α-Sarcin/Ricin Loop in the 28S rRNA

1997 • 463 citations

Involvement of growth factor receptors in the mammalian UVC response

1994 • 456 citations

Three distinct signalling responses by murine fibroblasts to genotoxic stress

1996 • 359 citations

The p38 and ERK MAP kinase pathways cooperate to activate Ternary Complex Factors and c-fos transcription in response to UV light.

1996 • 338 citations

UV-induced signal transduction

1997 • 277 citations

Activation of the c-fos gene by UV and phorbol ester: different signal transduction pathways converge to the same enhancer element.

1988 • 271 citations

UV-induced activation of AP-1 involves obligatory extranuclear steps including Raf-1 kinase.

1993 • 262 citations

Protein Synthesis Inhibitors Reveal Differential Regulation of Mitogen-Activated Protein Kinase and Stress-Activated Protein Kinase Pathways That Converge on Elk-1

1995 • 243 citations

Convergence of MAP kinase pathways on the ternary complex factor Sap-1a

1997 • 226 citations

CREB is activated by UVC through a p38/HOG-1-dependent protein kinase

1997 • 217 citations

Fos is an essential component of the mammalian UV response.

1995 • 200 citations

Ribotoxin recognition of ribosomal RNA and a proposal for the mechanism of translocation

1992 • 193 citations

DNA damage-induced gene expression: Signal transduction and relation to growth factor signaling

1992 • 187 citations

The ribosome: Structure, function and evolution

1991 • 173 citations

The Structure of Ribosomal RNA: A Three‐Dimensional Jigsaw Puzzle

1995 • 162 citations

Fine Structure of the Peptidyl Transferase Centre on 23 S-like rRNAs Deduced from Chemical Probing of Antibiotic-Ribosome Complexes

1995 • 153 citations

The mammalian UV response: Mechanism of DNA damage induced gene expression

1994 • 94 citations

23S Ribosomal RNA mutations in halobacteria conferring resistance to the anti-80S ribosome targeted antibiotic anisomycin

1987 • 63 citations

Anti-peptidyl transferase leader peptides of attenuation-regulated chloramphenicol-resistance genes.

1994 • 61 citations

Radiation-induced activation of transcription factors in mammalian cells

1990 • 54 citations

A conserved secondary structural motif in 23S rRNA defines the site of interaction of amicetin, a universal inhibitor of peptide bond formation.

1994 • 47 citations

Loss of Cellular K+ Mimics Ribotoxic Stress

1998 • 43 citations

Thapsigargin-Induced Gene Expression in Nonexcitable Cells Is Dependent on Calcium Influx

1997 • 34 citations

Mutational Analysis of Two Highly Conserved UGG Sequences of 23 S rRNA from Escherichia coli

1996 • 31 citations

A mutation in the large subunit ribosomal RNA gene of Tetrahymena confers anisomycin resistance and cold sensitivity.

1991 • 23 citations

Transient inhibition of protein synthesis induces the immediate early gene VL30: alternative mechanism for thapsigargin-induced gene expression.

1995 • 14 citations