Common Methylenetetrahydrofolate Reductase Gene Mutation Leads to Hyperhomocysteinemia but Not to Vascular Disease

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The common 'thermolabile' variant of methylene tetrahydrofolate reductase is a major determinant of mild hyperhomocysteinaemia

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Kinetic basis of hyperhomocysteinemia in patients with chronic renal failure

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Homocysteine and Risk of Premature Coronary Heart Disease

1996 • 242 citations

Correlation of a Common Mutation in the Methylenetetrahydrofolate Reductase Gene With Plasma Homocysteine in Patients With Premature Coronary Artery Disease

1997 • 234 citations

Myocardial Infarction in Young Women in Relation to Plasma Total Homocysteine, Folate, and a Common Variant in the Methylenetetrahydrofolate Reductase Gene

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The effect of reduced glomerular filtration rate on plasma total homocysteine concentration

1996 • 233 citations

Thermolabile Methylenetetrahydrofolate Reductase in Coronary Artery Disease

1997 • 230 citations

Common Mutation in Methylenetetrahydrofolate Reductase

1996 • 226 citations

The natural history of vascular disease in homocystinuria and the effects of treatment

1997 • 224 citations

A Common Polymorphism in the Methylenetetrahydrofolate Reductase Gene, Homocysteine, and Ischemic Cerebrovascular Disease

1997 • 178 citations

Distribution in Healthy and Coronary Populations of the Methylenetetrahydrofolate Reductase (MTHFR) C ₆₇₇ T Mutation

1996 • 173 citations

Methylenetetrahydrofolate Reductase Gene and Coronary Artery Disease

1997 • 169 citations

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1992 • 150 citations

Genetic Polymorphism of Methylenetetrahydrofolate Reductase and Myocardial Infarction

1996 • 145 citations

The 677C→T mutation in the methylenetetrahydrofolate reductase gene: associations with plasma total homocysteine levels and risk of coronary atherosclerotic disease

1997 • 139 citations

A Mutation in the Methylenetetrahydrofolate Reductase Gene Is Not Associated With Increased Risk for Coronary Artery Disease or Myocardial Infarction

1997 • 104 citations

Genetic analysis of thermolabile methylenetetrahydrofolate reductase as a risk factor for myocardial infarction

1996 • 104 citations

A common mutation in methylenetetrahydrofolate reductase gene is not a major risk of coronary artery disease or myocardial infarction

1997 • 92 citations

The VITA Project: C677T mutation in the methylene‐tetrahydrofolate reductase gene and risk of venous thromboembolism

1997 • 81 citations

Hyperhomocyst(e)inemia and a Common Methylenetetrahydrofolate Reductase Mutation (Ala ²²³ Val MTHFR) in Patients With Inherited Thrombophilic Coagulation Defects

1997 • 53 citations

The odds ratio: a useful tool in neurosciences.

1989 • 49 citations

Deleted Work

1955 • 0 citations