A Mutation in the Methylenetetrahydrofolate Reductase Gene Is Not Associated With Increased Risk for Coronary Artery Disease or Myocardial Infarction

The Metabolic and Molecular Bases of Inherited Disease

1995 • 12,086 citations

A Quantitative Assessment of Plasma Homocysteine as a Risk Factor for Vascular Disease

1995 • 3,645 citations

Vitamin Status and Intake as Primary Determinants of Homocysteinemia in an Elderly Population

1993 • 1,920 citations

Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis.

1969 • 1,846 citations

A Prospective Study of Plasma Homocyst(e)ine and Risk of Myocardial Infarction in US Physicians

1992 • 1,686 citations

Relation Between Folate Status, a Common Mutation in Methylenetetrahydrofolate Reductase, and Plasma Homocysteine Concentrations

1996 • 1,423 citations

Association between Plasma Homocysteine Concentrations and Extracranial Carotid-Artery Stenosis

1995 • 1,244 citations

Hyperhomocysteinemia as a Risk Factor for Deep-Vein Thrombosis

1996 • 1,034 citations

Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida

1995 • 870 citations

Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease.

1996 • 670 citations

Serum Total Homocysteine and Coronary Heart Disease

1995 • 668 citations

Thermolabile methylenetetrahydrofolate reductase: an inherited risk factor for coronary artery disease.

1991 • 615 citations

Methylenetetrahydrofolate Reductase Polymorphism, Plasma Folate, Homocysteine, and Risk of Myocardial Infarction in US Physicians

1996 • 496 citations

Homocysteine Metabolism and Risk of Myocardial Infarction: Relation with Vitamins B6, B12, and Folate

1996 • 493 citations

Elevation of total homocysteine in the serum of patients with cobalamin or folate deficiency detected by capillary gas chromatography-mass spectrometry.

1988 • 479 citations

Carotid artery intimal-medial wall thickening and plasma homocyst(e)ine in asymptomatic adults. The Atherosclerosis Risk in Communities Study.

1993 • 460 citations

Homocysteinemia due to folate deficiency

1987 • 423 citations

Thermolabile 5,10-methylenetetrahydrofolate reductase as a cause of mild hyperhomocysteinemia.

1995 • 421 citations

Hyperhomocysteinemia and Low Pyridoxal Phosphate

1995 • 401 citations

Impaired homocysteine metabolism in early-onset cerebral and peripheral occlusive arterial disease Effects of pyridoxine and folic acid treatment

1990 • 397 citations

A prospective study of plasma homocyst(e)ine and risk of ischemic stroke.

1994 • 386 citations

Myocardial Infarction and Mortality in the Coronary Artery Surgery Study (CASS) Randomized Trial

1984 • 365 citations

A genetic defect in 5,10 methylenetetrahydrofolate reductase in neural tube defects

1995 • 314 citations

Plasma homocyst(e)ine levels in men with premature coronary artery disease

1990 • 304 citations

Hyperhomocysteinaemia in stroke: prevalence, cause, and relationships to type of stroke and stroke risk factors

1992 • 261 citations

Thermolabile defect of methylenetetrahydrofolate reductase in coronary artery disease.

1993 • 230 citations

Inherited disorders of folate transport and metabolism

1995 • 201 citations

Genetic distances between the Utah Mormons and related populations.

1984 • 180 citations

Methylenetetrahydrofolate Reductase Gene and Coronary Artery Disease

1997 • 169 citations

Genetic Polymorphism of Methylenetetrahydrofolate Reductase and Myocardial Infarction

1996 • 145 citations

Thermolabile defect of methylenetetrahydrofolate reductase in coronary artery disease.

1993 • 143 citations

Apolipoprotein polymorphisms fail to define risk of coronary artery disease. Results of a prospective, angiographically controlled study.

1994 • 79 citations

Immune response factors in rheumatic heart disease: meta-analysis of HLA-DR associations and evaluation of additional class II alleles

1995 • 33 citations

Thermolabile Methylenetetrahydrofolate Reductase

1997 • 24 citations