Inactivation of the p53 protein in cell lines derived from human esophageal cancers

Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

1994 • 2,460 citations

p53: puzzle and paradigm.

1996 • 2,363 citations

Estimates of the worldwide incidence of eighteen major cancers in 1985

1993 • 1,680 citations

p53: A Frequent Target for Genetic Abnormalities in Lung Cancer

1989 • 1,214 citations

Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma

1993 • 884 citations

A transcriptionally active DNA-binding site for human p53 protein complexes.

1992 • 729 citations

Fusion of PAX7 to FKHR by the variant t(1;13)(p36;q14) translocation in alveolar rhabdomyosarcoma.

1994 • 580 citations

Somatic point mutations in the p53 gene of human tumors and cell lines: updated compilation

1996 • 508 citations

Pax-2 is a DNA-binding protein expressed in embryonic kidney and Wilms tumor.

1992 • 417 citations

Frequent mutation of the p53 gene in human esophageal cancer.

1990 • 393 citations

p53 mutations, ras mutations, and p53-heat shock 70 protein complexes in human lung carcinoma cell lines.

1991 • 349 citations

Genetic alterations in esophageal cancer and their relevance to etiology and pathogenesis: A review

1996 • 299 citations

Loss of p53 function through PAX-mediated transcriptional repression.

1995 • 236 citations

PAX8, a human paired box gene: isolation and expression in developing thyroid, kidney and Wilms’ tumors

1992 • 223 citations

Abnormal structure and expression of the p53 gene in human ovarian carcinoma cell lines.

1992 • 213 citations

Molecular basis for heterogeneity of the human p53 protein.

1986 • 167 citations

Detection of aberrations of the p53 alleles and the gene transcript in human tumor cell lines by single-strand conformation polymorphism analysis.

1991 • 165 citations

p53 gene mutations in gastric cancer metastases and in gastric cancer cell lines derived from metastases.

1991 • 150 citations

Retinoblastoma and p 53 tumor suppressor genes in human hepatoma cell lines

1993 • 128 citations

Altered messenger RNA and unique mutational profiles of p53 and Rb in human esophageal carcinomas.

1993 • 118 citations

Characterization of the human p53 gene promoter.

1989 • 108 citations

The tumor suppressor protein p53

1995 • 98 citations

Specific DNA binding by different classes of human p53 mutants.

1995 • 81 citations

PAX5 expression correlates with increasing malignancy in human astrocytomas.

1995 • 79 citations

The tumor suppressor protein p53

1995 • 74 citations

Characterization ofp53 gene mutations in esophageal squamous cell carcinoma cell lines: Increased frequency and different spectrum of mutations from primary tumors

1996 • 51 citations

Loss of heterozygosity of the short arm of chromosomes 3 and 9 in oral cancer

1996 • 49 citations

Expression and stability of p53 protein in normal human mammary epithelial cells

1993 • 46 citations

Epidemiology of oesophageal cancer

1994 • 30 citations

p53 mutations in esophageal tumors from high‐incidence areas of China

1995 • 30 citations

mRNA and protein expression of p53 mutations in human bladder cancer cell lines

1994 • 27 citations

Expression of cyclin D1, CDK4 and p27KIP1 is associated with the p16MTS1 gene status in human esophageal carcinoma cell lines.

1996 • 22 citations

Genomic DNA and messenger rna expression alterations of the CDKN2B and CDKN2 genes in esophageal squamous carcinoma cell lines

1995 • 16 citations

A unique p53 intragenic deletion flanked by short direct repeats results in loss ofmRNA expression in a human esophageal carcinoma

1994 • 8 citations