Detection of aberrations of the p53 alleles and the gene transcript in human tumor cell lines by single-strand conformation polymorphism analysis.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

1990 • 3,720 citations

Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms.

1989 • 3,707 citations

Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction

1989 • 3,557 citations

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

1986 • 2,968 citations

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

1988 • 2,121 citations

Generation of single-stranded DNA by the polymerase chain reaction and its application to direct sequencing of the HLA-DQA locus.

1988 • 1,582 citations

Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma.

1983 • 764 citations

Diagnosis of chronic myeloid and acute lymphocytic leukemias by detection of leukemia-specific mRNA sequences amplified in vitro.

1988 • 741 citations

Major deletions in the gene encoding the p53 tumor antigen cause lack of p53 expression in HL-60 cells.

1985 • 414 citations

Abnormal structure and expression of p53 gene in human hepatocellular carcinoma.

1990 • 413 citations

The HL-60 transforming sequence: A ras oncogene coexisting with altered myc genes in hematopoietic tumors

1983 • 341 citations

A variation in the structure of the protein-coding region of the human p53 gene

1988 • 286 citations

Use of labeled primers in polymerase chain reaction (LP-PCR) for a rapid detection of the product

1989 • 57 citations

Giant cell carcinomas of the lung producing colony-stimulating factor in vitro and in vivo.

1985 • 45 citations

Inactivation of the retinoblastoma gene in a human lung carcinoma cell line detected by single-strand conformation polymorphism analysis of the polymerase chain reaction product of cDNA

1991 • 42 citations

Increased expression of the c-myc gene without gene amplification in human lung cancer and colon cancer cell lines.

1986 • 21 citations