mRNA and protein expression of p53 mutations in human bladder cancer cell lines

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.

1980 • 8,711 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction

1989 • 3,557 citations

A general method for isolation of high molecular weight DNA from eukaryotes

1976 • 2,827 citations

Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas

1989 • 2,081 citations

Mutational hot spot in the p53 gene in human hepatocellular carcinomas

1991 • 1,525 citations

p53 mutations in colorectal cancer.

1990 • 1,030 citations

Identification of p53 Gene Mutations in Bladder Cancers and Urine Samples

1991 • 891 citations

Wild-type p53 can inhibit oncogene-mediated focus formation.

1989 • 738 citations

Structural aspects of the p53 protein in relation to gene evolution.

1990 • 618 citations

Detection of p53 Gene Mutations in Human Brain Tumors by Single-strand Conformation Polymorphism Analysis of Polymerase Chain Reaction Products

1991 • 556 citations

Nuclear Overexpression of p53 Protein in Transitional Cell Bladder Carcinoma: A Marker for Disease Progression

1993 • 544 citations

Established cell line of urinary bladder carcinoma (T24) containing tumour‐specific antigen

1973 • 514 citations

Localization of gene for human p53 tumour antigen to band 17p13

1986 • 498 citations

Primary structure polymorphism at amino acid residue 72 of human p53.

1987 • 466 citations

p53 nuclear protein accumulation correlates with mutations in the p53 gene, tumor grade, and stage in bladder cancer.

1993 • 464 citations

Nonsense mutations in the dihydrofolate reductase gene affect RNA processing.

1989 • 367 citations

Characterization of the human p53 gene.

1986 • 321 citations

Two distinct mechanisms regulate the levels of a cellular tumor antigen, p53.

1983 • 313 citations

Frequent association of p53 gene mutation in Invasive bladder cancer

1992 • 265 citations

A Human Tissue Culture Cell Line from a Transitional Cell Tumour of the Urinary Bladder: Growth, Chromosome Pattern and Ultrastructure

1970 • 254 citations

Nonsense mutations in the human beta-globin gene affect mRNA metabolism.

1988 • 229 citations

Human p53 gene localized to short arm of chromosome 17

1986 • 222 citations

Inactivation of the retinoblastoma gene in human bladder and renal cell carcinomas.

1991 • 184 citations

Expression of mutant p53, c-erbB-2 and the epidermal growth factor receptor in transitional cell carcinoma of the human urinary bladder

1991 • 181 citations

Distinct pattern of p53 mutations in bladder cancer: relationship to tobacco usage.

1993 • 170 citations

Translation to near the distal end of the penultimate exon is required for normal levels of spliced triosephosphate isomerase mRNA.

1990 • 159 citations

Human Bladder Carcinoma: Characterization of Two New Tumor Cell Lines and Search for Tumor Viruses23

1977 • 131 citations

Gene mutations and increased levels of p53 protein in human squamous cell carcinomas and their cell lines

1993 • 127 citations

Identification of intronic point mutations as an alternative mechanism for p53 inactivation in lung cancer.

1990 • 127 citations

Influence of cigarette smoking and schistosomiasis on p53 gene mutation in urothelial cancer.

1993 • 115 citations

Mutation of H-ras is infrequent in bladder cancer: confirmation by single-strand conformation polymorphism analysis, designed restriction fragment length polymorphisms, and direct sequencing.

1993 • 114 citations

The p53 tumor‐suppressor gene and ras oncogene mutations in oral squamous‐cell carcinoma

1992 • 105 citations

p53 immunohistochemistry in transitional cell carcinoma and dysplasia of the urinary bladder correlates with disease progression

1993 • 94 citations

Molecular Genetic Alterations of Chromosome 17 and p53 Nuclear Overexpression in Human Bladder Cancer

1993 • 94 citations

p53 anderbB-2 protein overexpression are associated with early invasion and metastasis in bladder cancer

1993 • 68 citations

A cell line (SCaBER) derived from squamous cell carcinoma of the human urinary bladder

1976 • 64 citations

Molecular basis for nondeletion alpha-thalassemia in American blacks. Alpha 2(116GAG----UAG).

1987 • 51 citations

Effect of Glutathione and its Related Enzymes on Chemosensitivity of Renal Cell Carcinoma and Bladder Carcinoma Cell Lines

1994 • 48 citations

Mutation of p53 in primary biopsy material and cell lines from Hodgkin disease.

1993 • 44 citations

Molecular Genetic Alterations of Chromosome 17 and p53 Nuclear Overexpression in Human Bladder Cancer

1993 • 43 citations

A splicing mutation accounts for the lack of p53 gene expression in a CML blast crisis cell line: a novel mechanism of p53 gene inactivation

1990 • 40 citations

Expression of intercellular adhesion molecule-1 on transitional cell cancer. Possible significance in immunity against tumor cells.

1993 • 37 citations

Point mutation of the p53 gene resulting in splicing inhibition in small cell lung carcinoma

1990 • 34 citations

Mutations of the p53 gene in carcinomas of the urinary system

1993 • 14 citations

A new in vivo model for studying invasion and metastasis of rat and human bladder carcinomas

1993 • 13 citations

Inhibitory effects on in vitro cell growth of human urothelial tumor cell lines under the combined administration of hematopoietic growth factors and clinically relevant antineoplastic agents

1993 • 7 citations

Mutations of the p53 gene in carcinomas of the urinary system

1994 • 6 citations