Differential Transcriptional Control of the Superoxide Dismutase-2 κB Element in Neurons and Astrocytes

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

2012 • 8,865 citations

NMDA-dependent superoxide production and neurotoxicity

1993 • 1,188 citations

The Sp-family of transcription factors

1999 • 1,098 citations

Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice.

1996 • 1,020 citations

The Rel/NF-κB Family Directly Activates Expression of the Apoptosis Inhibitor Bcl-x_L

2000 • 747 citations

Sp1 and TAFII130 Transcriptional Activity Disrupted in Early Huntington's Disease

2002 • 692 citations

Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E

1997 • 601 citations

Transcription Factor Sp1 Is Essential for Early Embryonic Development but Dispensable for Cell Growth and Differentiation

1997 • 524 citations

Increased mitochondrial oxidative stress in the Sod2 (+/−) mouse results in the age-related decline of mitochondrial function culminating in increased apoptosis

2001 • 478 citations

Regulation of the activity of Sp1-related transcription factors

2002 • 445 citations

Different activation domains of Sp1 govern formation of multimers and mediate transcriptional synergism.

1991 • 437 citations

Interaction of Huntington Disease Protein with Transcriptional Activator Sp1

2002 • 336 citations

Manganese Superoxide Dismutase Mediates the Early Release of Mitochondrial Cytochrome C and Subsequent DNA Fragmentation after Permanent Focal Cerebral Ischemia in Mice

1999 • 315 citations

Major Histocompatibility Complex (MHC) Class I Gene Expression in Single Neurons of the Central Nervous System: Differential Regulation by Interferon (IFN)-γ and Tumor Necrosis Factor (TNF)-α

1997 • 284 citations

NMDA Receptor Activation Produces Concurrent Generation of Nitric Oxide and Reactive Oxygen Species: Implications for Cell Death

1995 • 280 citations

Activation-Dependent Transcriptional Regulation of the Human fas Promoter Requires NF-κB p50-p65 Recruitment

1999 • 232 citations

Tumor Necrosis Factor Alpha and Interleukin-1β Regulate the Murine Manganese Superoxide Dismutase Gene Through a Complex Intronic Enhancer Involving C/EBP-β and NF-κB

1997 • 231 citations

An Intronic NF-kappaB Element Is Essential for Induction of the Human Manganese Superoxide Dismutase Gene by Tumor Necrosis Factor-alpha and Interleukin-1beta

1999 • 225 citations

Transcription factor Sp3 is essential for post-natal survival and late tooth development

2000 • 192 citations

Strong nuclear factor-?B-DNA binding parallels cyclooxygenase-2 gene transcription in aging and in sporadic alzheimer's disease superior temporal lobe neocortex

1998 • 181 citations

Sp4, a Member of the Sp1-Family of Zinc Finger Transcription Factors, Is Required for Normal Murine Growth, Viability, and Male Fertility

1996 • 170 citations

Functional Interference of Sp1 and NF-κB through the Same DNA Binding Site

1998 • 160 citations

A Sod2 Null Mutation Confers Severely Reduced Adult Life Span in Drosophila

2003 • 154 citations

Interleukin-1β and Glutamate Activate the NF-κB/Rel Binding Site from the Regulatory Region of the Amyloid Precursor Protein Gene in Primary Neuronal Cultures

1996 • 152 citations

RNA Leaching of Transcription Factors Disrupts Transcription in Myotonic Dystrophy

2003 • 149 citations

Sp3 and Sp4 Can Repress Transcription by Competing with Sp1 for the Core cis-Elements on the Human ADH5/FDHMinimal Promoter

1999 • 126 citations

Transcriptional regulation of the human manganese superoxide dismutase gene: the role of specificity protein 1 (Sp1) and activating protein-2 (AP-2)

2002 • 126 citations

Nuclear factor κB-dependent mechanisms coordinate the synergistic effect of PMA and cytokines on the induction of superoxide dismutase 2

2000 • 115 citations

S100β Induction of the Proinflammatory Cytokine Interleukin‐6 in Neurons

2000 • 111 citations

Complexity of Translationally Controlled Transcription Factor Sp3 Isoform Expression

2004 • 108 citations

Cyclooxygenase-2 is a neuronal target gene of NF-kappaB.

2002 • 107 citations

Modulation of Synaptic Transmission by the BCL-2 Family Protein BCL-xL

2003 • 98 citations

NF-κB Site Interacts with Sp Factors and Up-regulates the NR1 Promoter during Neuronal Differentiation

2004 • 87 citations

Reduced expression of the Sp4 gene in mice causes deficits in sensorimotor gating and memory associated with hippocampal vacuolization

2004 • 83 citations

The Mammalian Transcriptional Repressor RBP (CBF1) Regulates Interleukin-6 Gene Expression

1997 • 80 citations

Role of Sp1 in cAMP-dependent Transcriptional Regulation of the Bovine CYP11A Gene

1999 • 77 citations

Transcriptional regulation of the human manganese superoxide dismutase gene: the role of specificity protein 1 (Sp1) and activating protein-2 (AP-2)

2002 • 70 citations

Transcriptional Activity of Sp1 Is Regulated by Molecular Interactions between the Zinc Finger DNA Binding Domain and the Inhibitory Domain with Corepressors, and This Interaction Is Modulated by MEK

2005 • 70 citations

Retinoic acid induction of major histocompatibility complex class I genes in NTera-2 embryonal carcinoma cells involves induction of NF-kappa B (p50-p65) and retinoic acid receptor beta-retinoid X receptor beta heterodimers.

1993 • 62 citations

The cannabinoid dexanabinol is an inhibitor of the nuclear factor-kappa B (NF-κB)

2004 • 53 citations

Glutamate receptor activation evokes calpain‐mediated degradation of Sp3 and Sp4, the prominent Sp‐family transcription factors in neurons

2006 • 51 citations

NFκB in neurons? The Uncertainty Principle in neurobiology

2006 • 51 citations

Novel Transcriptional Regulation of the Human CYP3A7Gene by Sp1 and Sp3 through Nuclear Factor κB-like Element

2001 • 50 citations

Characterization of a neuronal κB-binding factor distinct from NF-κB

1999 • 47 citations

Transcriptional Regulation of Mouse μ Opioid Receptor Gene: Sp3 Isoforms (M1, M2) Function as Repressors in Neuronal Cells to Regulate the μ Opioid Receptor Gene

2005 • 43 citations

Production of Human CNS Neurons from Embryonal Carcinoma Cells Using a Cell Aggregation Method

1999 • 42 citations

IIIIIIInteraction of Na⁺, K⁺, and Cl^‐ with the Binding of Amphetamine, Octopamine, and Tyramine to the Human Dopamine Transporter

2000 • 38 citations

Molecular Mechanisms of Cytokine-Induced Neuroprotection: NFκB and Neuroplasticity

2005 • 37 citations

Neuronal κB-binding Factors Consist of Sp1-related Proteins

2002 • 35 citations

Transcriptional regulation of rat Na⁺/H⁺exchanger isoform-2 (NHE-2) gene by Sp1 transcription factor

2001 • 30 citations

Inhibition of the activity of a neuronal kappaB-binding factor by glutamate.

1999 • 22 citations

Specific Deficiency in Nuclear Factor-κB Activation in Neurons of the Central Nervous System

2001 • 21 citations

Members of the Sp transcription factor family regulate rat calmodulin gene expression

2000 • 20 citations

Inhibition of the Activity of a Neuronal κB‐Binding Factor by Glutamate

1999 • 19 citations

Retinoic Acid Induction of Major Histocompatibility Complex Class I Genes in NTera-2 Embryonal Carcinoma Cells Involves Induction of NF-κB (p50-p65) and Retinoic Acid Receptor β-Retinoid X Receptor β Heterodimers

1993 • 18 citations

Oral Session O04: Intracellular signaling in glia and neurons

2005 • 4 citations