ENTPD1/CD39 is a promising therapeutic target in oncology

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

2004 • 4,872 citations

Ipilimumab plus Dacarbazine for Previously Untreated Metastatic Melanoma

2011 • 4,304 citations

Enhancement of Antitumor Immunity by CTLA-4 Blockade

1996 • 3,585 citations

How regulatory T cells work

2008 • 3,048 citations

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression

2007 • 2,215 citations

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

2009 • 1,694 citations

Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma

2003 • 1,564 citations

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

2009 • 1,449 citations

Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice

2011 • 1,226 citations

Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression

2007 • 1,181 citations

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

1995 • 1,079 citations

Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells

2005 • 998 citations

Transient expression of FOXP3 in human activated nonregulatory CD4⁺ T cells

2006 • 973 citations

A2A adenosine receptor protects tumors from antitumor T cells

2006 • 923 citations

Regulatory T cells in tumor immunity

2010 • 902 citations

Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti–CTLA-4 antibodies

2009 • 882 citations

Interleukin-2–Receptor Blockade with Daclizumab to Prevent Acute Rejection in Renal Transplantation

1998 • 875 citations

Induction and mechanism of action of transforming growth factor‐β‐secreting Th3 regulatory cells

2001 • 856 citations

CD4⁺CD25⁺ regulatory T cells suppress tumor immunity but are sensitive to cyclophosphamide which allows immunotherapy of established tumors to be curative

2004 • 854 citations

Type 1 T regulatory cells

2001 • 829 citations

Ipilimumab (Anti-CTLA4 Antibody) Causes Regression of Metastatic Renal Cell Cancer Associated With Enteritis and Hypophysitis

2007 • 673 citations

Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation

1999 • 554 citations

Extracellular adenosine triphosphate and adenosine in cancer

2010 • 531 citations

The Expression of the Regulatory T Cell–Specific Forkhead Box Transcription Factor FoxP3 Is Associated with Poor Prognosis in Ovarian Cancer

2005 • 494 citations

Cancer Exosomes Express CD39 and CD73, Which Suppress T Cells through Adenosine Production

2011 • 483 citations

Role of A2a Extracellular Adenosine Receptor-Mediated Signaling in Adenosine-Mediated Inhibition of T-Cell Activation and Expansion

1997 • 479 citations

TGF-β regulatesin vivoexpansion of Foxp3-expressing CD4⁺CD25⁺regulatory T cells responsible for protection against diabetes

2004 • 425 citations

Intratumor depletion of CD4+ cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors

2005 • 423 citations

Intratumoral CD4+CD25+ regulatory T-cell-mediated suppression of infiltrating CD4+ T cells in B-cell non-Hodgkin lymphoma

2006 • 412 citations

Regulatory T-cell inhibition versus depletion: the right choice in cancer immunotherapy

2007 • 406 citations

Triggering of OX40 (CD134) on CD4+CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR

2005 • 406 citations

Cutting Edge: TGF-β Signaling Is Required for the In Vivo Expansion and Immunosuppressive Capacity of Regulatory CD4+CD25+ T Cells

2004 • 395 citations

Adenosine receptors in regulation of dendritic cell differentiation and function

2008 • 384 citations

Modulation of tryptophan catabolism by human leukemic cells results in the conversion of CD25− into CD25+ T regulatory cells

2006 • 377 citations

Generation and Accumulation of Immunosuppressive Adenosine by Human CD4+CD25highFOXP3+ Regulatory T Cells

2009 • 363 citations

Ecto‐enzyme and signaling functions of lymphocyte CD 7 3

1998 • 322 citations

In vivo peripheral expansion of naive CD4+CD25highFoxP3+ regulatory T cells in patients with multiple myeloma

2006 • 290 citations

Depletion of human regulatory T cells specifically enhances antigen-specific immune responses to cancer vaccines

2008 • 288 citations

CD39 and control of cellular immune responses

2007 • 281 citations

CD39 deletion exacerbates experimental murine colitis and human polymorphisms increase susceptibility to inflammatory bowel disease

2009 • 263 citations

CD39/ENTPD1 Expression by CD4+Foxp3+ Regulatory T Cells Promotes Hepatic Metastatic Tumor Growth in Mice

2010 • 258 citations

The CD39 lymphoid cell activation antigen. Molecular cloning and structural characterization.

1994 • 256 citations

Tumor-Induced Expansion of Regulatory T Cells by Conversion of CD4+CD25− Lymphocytes Is Thymus and Proliferation Independent

2006 • 252 citations

Depletion of CD25+ regulatory cells results in suppression of melanoma growth and induction of autoreactivity in mice.

2002 • 214 citations

Activation of A2A Adenosine Receptor Attenuates Intestinal Inflammation in Animal Models of Inflammatory Bowel Disease

2005 • 200 citations

Regulation of Macrophage Function by Adenosine

2012 • 197 citations

Selective Depletion of CD4+CD25+Foxp3+ Regulatory T Cells by Low-Dose Cyclophosphamide Is Explained by Reduced Intracellular ATP Levels

2010 • 193 citations

Frequency of regulatory T cells in renal cell carcinoma patients and investigation of correlation with survival

2007 • 191 citations

A2A Adenosine Receptor May Allow Expansion of T Cells Lacking Effector Functions in Extracellular Adenosine-Rich Microenvironments

2009 • 190 citations

Synergistic Up-Regulation of Vascular Endothelial Growth Factor Expression in Murine Macrophages by Adenosine A2A Receptor Agonists and Endotoxin

2002 • 187 citations

Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity

2011 • 175 citations

Polyoxometalates—a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors

2006 • 174 citations

Increased Ectonucleotidase Expression and Activity in Regulatory T Cells of Patients with Head and Neck Cancer

2009 • 166 citations

CD39/Adenosine Pathway Is Involved in AIDS Progression

2011 • 162 citations

Phase III, open-label, randomized, comparative study of tremelimumab (CP-675,206) and chemotherapy (temozolomide [TMZ] or dacarbazine [DTIC]) in patients with advanced melanoma

2008 • 159 citations

Transient T cell depletion causes regression of melanoma metastases

2008 • 153 citations

Altered purinergic signaling in CD73‐deficient mice inhibits tumor progression

2011 • 137 citations

Vascular CD39/ENTPD1 Directly Promotes Tumor Cell Growth by Scavenging Extracellular Adenosine Triphosphate

2011 • 135 citations

Adenosine-Mediated Inhibition of the Cytotoxic Activity and Cytokine Production by Activated Natural Killer Cells

2006 • 127 citations

Upregulation of CD39/NTPDases and P2 receptors in human pancreatic disease

2006 • 124 citations

Analysis of CD39/ATP Diphosphohydrolase (ATPDase) Expression in Endothelial Cells, Platelets and Leukocytes

1999 • 123 citations

Low-dose Cyclophosphamide Treatment Impairs Regulatory T Cells and Unmasks AFP-specific CD4+ T-cell Responses in Patients With Advanced HCC

2010 • 122 citations

Impact of CD39 and purinergic signalling on the growth and metastasis of colorectal cancer

2011 • 118 citations

Synergistic Up-Regulation of Vascular Endothelial Growth Factor (VEGF) Expression in Macrophages by Adenosine A_2AReceptor Agonists and Endotoxin Involves Transcriptional Regulation via the Hypoxia Response Element in the VEGF Promoter

2006 • 117 citations

Regulatory T Cells Are Reduced During Anti-CD25 Antibody Treatment of Multiple Sclerosis

2009 • 96 citations

Disordered Purinergic Signaling Inhibits Pathological Angiogenesis in Cd39/Entpd1-Null Mice

2007 • 95 citations

CD39/NTPDase-1 activity and expression in normal leukocytes

2007 • 92 citations

Extracellular ATP induces ion fluxes and inhibits growth of Friend erythroleukemia cells.

1984 • 85 citations

P2X7 Receptor-Dependent Cell Death Is Modulated during Murine T Cell Maturation and Mediated by Dual Signaling Pathways

2006 • 80 citations

CTLA-4 blockade: therapeutic potential in cancer treatments

2010 • 78 citations

Adenosine receptors are expressed during differentiation of monocytes to macrophages in vitro. Implications for regulation of phagocytosis.

1989 • 78 citations

Human Follicular Lymphoma CD39+-Infiltrating T Cells Contribute to Adenosine-Mediated T Cell Hyporesponsiveness

2009 • 77 citations

Growth inhibition of human tumor cells in soft-agar cultures by treatment with low levels of adenosine 5'-triphosphate.

1983 • 76 citations

Anti-CD25 Antibody-Mediated Depletion of Effector T Cell Populations Enhances Susceptibility of Mice to Acute but Not Chronic Toxoplasma gondii Infection

2009 • 74 citations

The novel NTPDase inhibitor sodium polyoxotungstate (POM-1) inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition

2008 • 74 citations

Separation of human CD4+CD39+ T cells by magnetic beads reveals two phenotypically and functionally different subsets

2011 • 73 citations

CD39 Expression on T Lymphocytes Correlates With Severity of Disease in Patients With Chronic Lymphocytic Leukemia

2011 • 70 citations

Isolated CD39 Expression on CD4+ T Cells Denotes both Regulatory and Memory Populations

2009 • 69 citations

An in vivo model of melanoma: treatment with ATP

2009 • 57 citations

Adenosine receptors and modulation of natural killer cell activity by purine nucleosides.

1990 • 54 citations

IFN-α and CD46 stimulation are associated with active lupus and skew natural T regulatory cell differentiation to type 1 regulatory T (Tr1) cells

2011 • 51 citations

Adenosine Acts through a Novel Extracellular Receptor to Inhibit Granule Exocytosis by Natural Killer Cells

1997 • 44 citations

The CD39 molecule defines distinct cytotoxic subsets within alloactivated human CD8‐positive cells

1992 • 32 citations

Regulatory T Cells from IL-10-Deficient Mice Fail to Suppress Contact Hypersensitivity Reactions Due to Lack of Adenosine Production

2011 • 27 citations

Deleted Work

1955 • 0 citations