Interaction of Hic-5, A Senescence-related Protein, with Focal Adhesion Kinase

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Production of high-titer helper-free retroviruses by transient transfection.

1993 • 2,280 citations

Focal Adhesions: Transmembrane Junctions Between the Extracellular Matrix and the Cytoskeleton

1988 • 2,137 citations

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1990 • 2,129 citations

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

1995 • 1,810 citations

Signal transduction from the extracellular matrix.

1993 • 1,727 citations

VLA Proteins in the Integrin Family: Structures, Functions, and Their Role on Leukocytes

1990 • 1,592 citations

Integrins: Emerging Paradigms of Signal Transduction

1995 • 1,591 citations

pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions.

1992 • 1,456 citations

Anchorage dependence, integrins, and apoptosis

1994 • 1,016 citations

A ras-related gene with transformation suppressor activity

1989 • 979 citations

MAPKs: new JNK expands the group

1994 • 949 citations

Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase

1991 • 869 citations

A novel viral oncogene with structural similarity to phospholipase C

1988 • 789 citations

Paxillin: a new vinculin-binding protein present in focal adhesions.

1990 • 687 citations

CAS/Crk Coupling Serves as a “Molecular Switch” for Induction of Cell Migration

1998 • 668 citations

A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner.

1994 • 653 citations

pp125^FAK-Dependent Tyrosine Phosphorylation of Paxillin Creates a High-Affinity Binding Site for Crk

1995 • 534 citations

Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK.

1994 • 525 citations

Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation.

1996 • 514 citations

A mechanism for regulation of the adhesion-associated protein tyrosine kinase pp125FAK

1996 • 488 citations

Signaling through focal adhesion kinase

1997 • 468 citations

Costimulation of proliferative responses of resting CD4+ T cells by the interaction of VLA-4 and VLA-5 with fibronectin or VLA-6 with laminin.

1990 • 400 citations

C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins.

1994 • 391 citations

Identification of Rap1 as a Target for the Crk SH3 Domain-Binding Guanine Nucleotide-Releasing Factor C3G

1995 • 359 citations

Identification of LIM3 as the principal determinant of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion kinase binding.

1996 • 347 citations

Characterization of Tyrosine Phosphorylation of Paxillin in Vitro by Focal Adhesion Kinase

1995 • 334 citations

Primary sequence of paxillin contains putative SH2 and SH3 domain binding motifs and multiple LIM domains: identification of a vinculin and pp125Fak- binding region

1994 • 311 citations

Activation of CD4 cells by fibronectin and anti-CD3 antibody. A synergistic effect mediated by the VLA-5 fibronectin receptor complex.

1989 • 291 citations

Molecular Cloning Of Human Paxillin, a Focal Adhesion Protein Phosphorylated by P210BCR/ABL

1995 • 275 citations

Direct association of pp125FAK with paxillin, the focal adhesion-targeting mechanism of pp125FAK.

1995 • 261 citations

Differential Inhibition of Signaling Pathways by Dominant-Negative SH2/SH3 Adapter Proteins

1995 • 233 citations

Characterization of the TGF beta 1-inducible hic-5 gene that encodes a putative novel zinc finger protein and its possible involvement in cellular senescence.

1994 • 207 citations

Structure and function of Cas-L, a 105-kD Crk-associated substrate-related protein that is involved in beta 1 integrin-mediated signaling in lymphocytes.

1996 • 165 citations

Tyrosine Phosphorylation of Crk-associated Substrates by Focal Adhesion Kinase

1997 • 155 citations

Characterisation of the paxillin-binding site and the C-terminal focal adhesion targeting sequence in vinculin

1994 • 151 citations

Downstream of Crk adaptor signaling pathway: Activation of Jun kinase by v-Crk through the guanine nucleotide exchange protein C3G

1997 • 135 citations

Cell Adhesion Kinase β Forms a Complex with a New Member, Hic-5, of Proteins Localized at Focal Adhesions

1998 • 127 citations

Cellular proteins binding to the first Src homology 3 (SH3) domain of the proto-oncogene product c-Crk indicate Crk-specific signaling pathways.

1995 • 100 citations

Induction of Senescence-Like Phenotypes by Forced Expression of hic-5, Which Encodes a Novel LIM Motif Protein, in Immortalized Human Fibroblasts

1997 • 97 citations

CrkII signals from epidermal growth factor receptor to Ras.

1996 • 32 citations