GENETICS OF SYNAPTIC VESICLE FUNCTION: Toward the Complete Functional Anatomy of an Organelle

SNAREpins: Minimal Machinery for Membrane Fusion

1998 • 2,456 citations

The synaptic vesicle cycle: a cascade of protein–protein interactions

1995 • 2,004 citations

Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin

1992 • 1,792 citations

Synaptotagmin I: A major Ca2+ sensor for transmitter release at a central synapse

1994 • 1,485 citations

Synaptic vesicle exocytosis captured by quick freezing and correlated with quantal transmitter release.

1979 • 1,408 citations

Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25

1993 • 1,200 citations

Impaired Long-Term Potentiation, Spatial Learning, and Hippocampal Development in fyn Mutant Mice

1992 • 1,138 citations

Definition of the Readily Releasable Pool of Vesicles at Hippocampal Synapses

1996 • 1,088 citations

The Fine Structure of the Nervous System

1991 • 1,058 citations

Identification and characterization of the vesicular GABA transporter

1997 • 860 citations

A 38,000-dalton membrane protein (p38) present in synaptic vesicles.

1985 • 856 citations

Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly.

1994 • 798 citations

Structure and Conformational Changes in NSF and Its Membrane Receptor Complexes Visualized by Quick-Freeze/Deep-Etch Electron Microscopy

1997 • 788 citations

ZnT-3, a putative transporter of zinc into synaptic vesicles

1996 • 712 citations

Essential functions of synapsins I and II in synaptic vesicle regulation

1995 • 699 citations

The release of neural transmitter substances

1970 • 685 citations

Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion

1997 • 673 citations

Nonuniform Probability of Glutamate Release at a Hippocampal Synapse

1993 • 641 citations

The probability of transmitter release at a mammalian central synapse

1993 • 632 citations

Ca2+-dependent and -independent activities of neural and non-neural synaptotagmins

1995 • 597 citations

STRUCTURE, FUNCTION AND REGULATION OF THE VACUOLAR (H⁺)-ATPase

1997 • 588 citations

Release of secretory products during transient vesicle fusion

1993 • 582 citations

Synaptic function is impaired but not eliminated in C. elegans mutants lacking synaptotagmin

1993 • 551 citations

Botulinum neurotoxin C1 blocks neurotransmitter release by means of cleaving HPC-1/syntaxin.

1993 • 540 citations

Synapsins: Mosaics of Shared and Individual Domains in a Family of Synaptic Vesicle Phosphoproteins

1989 • 535 citations

Two components of transmitter release at a central synapse.

1994 • 528 citations

Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors

1991 • 520 citations

Cellubrevin is a ubiquitous tetanus-toxin substrate homologous to a putative synaptic vesicle fusion protein

1993 • 504 citations

The role of Rab3A in neurotransmitter release

1994 • 481 citations

Expression cloning of a reserpine-sensitive vesicular monoamine transporter.

1992 • 481 citations

Geometric packing constraints in egg phosphatidylcholine vesicles.

1978 • 469 citations

Mutational analysis of Drosophila synaptotagmin demonstrates its essential role in Ca2+-activated neurotransmitter release

1993 • 457 citations

Synaptotagmins: C2-Domain Proteins That Regulate Membrane Traffic

1996 • 439 citations

Timing of neurotransmission at fast synapses in the mammalian brain

1996 • 432 citations

VMAT2 knockout mice: Heterozygotes display reduced amphetamine-conditioned reward, enhanced amphetamine locomotion, and enhanced MPTP toxicity

1997 • 420 citations

The small GTP-binding protein Rab3A regulates a late step in synaptic vesicle fusion

1997 • 414 citations

Real-time measurement of transmitter release from single synaptic vesicles

1995 • 404 citations

Differential expression of synaptic vesicle protein 2 (SV2) isoforms

1994 • 391 citations

Sec9 is a SNAP-25-like component of a yeast SNARE complex that may be the effector of Sec4 function in exocytosis

1994 • 380 citations

Knockout of the Vesicular Monoamine Transporter 2 Gene Results in Neonatal Death and Supersensitivity to Cocaine and Amphetamine

1997 • 378 citations

Caenorhabditis elegans rab-3Mutant Synapses Exhibit Impaired Function and Are Partially Depleted of Vesicles

1997 • 373 citations

Paralysis and Early Death in Cysteine String Protein Mutants of Drosophila

1994 • 367 citations

Vesicle hypothesis of the release of quanta of acetylcholine.

1980 • 364 citations

The Caenorhabditis elegans unc-17 Gene: a Putative Vesicular Acetylcholine Transporter

1993 • 361 citations

Rab3A is essential for mossy fibre long-term potentiation in the hippocampus

1997 • 360 citations

A novel gene involved in zinc transport is deficient in the lethal milk mouse

1997 • 359 citations

The organization of cytoplasm at the presynaptic active zone of a central nervous system synapse

1988 • 340 citations

Tetanus toxin action: Inhibition of neurotransmitter release linked to synaptobrevin proteolysis

1992 • 340 citations

Short-term synaptic plasticity is altered in mice lacking synapsin I

1993 • 332 citations

Two Vesicle-associated Membrane Protein Genes Are Differentially Expressed in the Rat Central Nervous System

1989 • 326 citations

The Localization of the Brain-Specific Inorganic Phosphate Transporter Suggests a Specific Presynaptic Role in Glutamatergic Transmission

1998 • 326 citations

A Synaptic Vesicle Protein with a Novel Cytoplasmic Domain and Four Transmembrane Regions

1987 • 326 citations

Ca2+ binding to synaptotagmin: how many Ca2+ ions bind to the tip of a C2-domain?

1998 • 313 citations

Genes required for GABA function in Caenorhabditis elegans

1993 • 303 citations

THE ROLE OF VESICULAR TRANSPORT PROTEINS IN SYNAPTIC TRANSMISSION AND NEURAL DEGENERATION

1997 • 297 citations

Synaptic vesicles retain their identity through the endocytic cycle

1998 • 271 citations

Synaptic transmission deficits in Caenorhabditis elegans synaptobrevin mutants.

1998 • 266 citations

Cleavage of members of the synaptobrevin/VAMP family by types D and F botulinal neurotoxins and tetanus toxin.

1994 • 261 citations

RAB3 AND SYNAPTOTAGMIN: The Yin and Yang of Synaptic Membrane Fusion

1998 • 260 citations

Putative Single Quantum and Single Fibre Excitatory Postsynaptic Currents Show Similar Amplitude Range and Variability in Rat Hippocampal Slices

1992 • 257 citations

The synaptic vesicle protein SV2 is a novel type of transmembrane transporter

1992 • 257 citations

Rabphilin-3A, a putative target protein for smg p25A/rab3A p25 small GTP-binding protein related to synaptotagmin.

1993 • 253 citations

Botulinum Neurotoxin C1 Cleaves both Syntaxin and SNAP-25 in Intact and Permeabilized Chromaffin Cells: Correlation with Its Blockade of Catecholamine Release

1996 • 252 citations

Synaptic vesicle endocytosis

1997 • 249 citations

Synaptic transmission persists in synaptotagmin mutants of Drosophila

1993 • 249 citations

A third member of the synapsin gene family

1998 • 237 citations

Synaptic Transmission Deficits inCaenorhabditis elegansSynaptobrevin Mutants

1998 • 235 citations

Distinct Requirements for Evoked and Spontaneous Release of Neurotransmitter Are Revealed by Mutations in theDrosophilaGeneneuronal-synaptobrevin

1998 • 233 citations

The preparation and characterization of synaptic vesicles of high purity

1976 • 221 citations

Membrane trafficking in the presynaptic nerve terminal

1995 • 217 citations

Synaptic targeting of rabphilin-3A, a synaptic vesicle Ca2+/phospholipid-binding protein, depends on rab3A/3C

1994 • 197 citations

Molecular cloning of a putative vesicular transporter for acetylcholine.

1994 • 183 citations

Brain contains two forms of synaptic vesicle protein 2.

1993 • 182 citations

Cysteine String Proteins: a Potential Link Between Synaptic Vesicles and Presynaptic Ca ²⁺ Channels

1994 • 180 citations

Expression of a Putative Vesicular Acetylcholine Transporter Facilitates Quantal Transmitter Packaging

1997 • 174 citations

Synaptic vesicle recycling in synapsin I knock-out mice.

1996 • 168 citations

Presynaptic dysfunction in drosophila csp mutants

1994 • 166 citations

The involvement of the small GTP-binding protein Rab5a in neuronal endocytosis

1994 • 152 citations

Ca²⁺or Sr²⁺Partially Rescues Synaptic Transmission in Hippocampal Cultures Treated with Botulinum Toxin A and C, But Not Tetanus Toxin

1997 • 147 citations

Rab3 reversibly recruits rabphilin to synaptic vesicles by a mechanism analogous to raf recruitment by ras.

1996 • 136 citations

Suppression cloning of the cDNA for a candidate subunit of a presynaptic calcium channel

1992 • 132 citations

Synapsin I is structurally similar to ATP-utilizing enzymes

1998 • 128 citations

Relative properties and localizations of synaptic vesicle protein isoforms: the case of the synaptophysins

1993 • 127 citations

Localization of Rab5 to synaptic vesicles identifies endosomal intermediate in synaptic vesicle recycling pathway.

1994 • 124 citations

Staurosporine blocks evoked release of FM1-43 but not acetylcholine from frog motor nerve terminals

1995 • 118 citations

Phosphorylation of rabphilin-3A by Ca2+/calmodulin- and cAMP-dependent protein kinases in vitro

1995 • 118 citations

Cysteine string protein, a DnaJ family member, is present on diverse secretory vesicles

1995 • 114 citations

The C2 Domains of Rabphilin3A Specifically Bind Phosphatidylinositol 4,5-Bisphosphate Containing Vesicles in a Ca2+-dependent Manner

1998 • 113 citations

The structure of the human synapsin I gene and protein.

1990 • 107 citations

Synapsins I and II Are ATP-binding Proteins with Differential Ca2+ Regulation

1998 • 97 citations

Synaptic Vesicle Traffic: Rush Hour in the Nerve Terminal

1993 • 95 citations

Synapsin III, a Novel Synapsin with an Unusual Regulation by Ca2+

1998 • 93 citations

SVOP, an Evolutionarily Conserved Synaptic Vesicle Protein, Suggests Novel Transport Functions of Synaptic Vesicles

1998 • 90 citations

DIFFERENT RECOVERY RATES OF THE ELECTROPHYSIOLOGICAL, BIOCHEMICAL AND MORPHOLOGICAL PARAMETERS IN THE CHOLINERGIC SYNAPSES OF THE TORPEDO ELECTRIC ORGAN AFTER STIMULATION

1974 • 88 citations

Region-Specific Phosphorylation of Rabphilin in Mossy Fiber Nerve Terminals of the Hippocampus

1998 • 88 citations

Structure of synaptogyrin (p29) defines novel synaptic vesicle protein.

1995 • 86 citations

SCAMP 37, a new marker within the general cell surface recycling system.

1993 • 81 citations

Cysteine String Protein Is Required for Calcium Secretion Coupling of Evoked Neurotransmission inDrosophilaBut Not for Vesicle Recycling

1998 • 80 citations

Noc2, a Putative Zinc Finger Protein Involved in Exocytosis in Endocrine Cells

1997 • 77 citations

Origin of transmitters released by electrical stimulation from a small, metabolically very active vesicular pool of cholinergic synapses in guinea-pig cerebral cortex

1979 • 77 citations

Pantophysin is a ubiquitously expressed synaptophysin homologue and defines constitutive transport vesicles.

1996 • 73 citations

Three mammalian SCAMPs (secretory carrier membrane proteins) are highly related products of distinct genes having similar subcellular distributions

1997 • 69 citations

Long-term potentiation in mice lacking synapsins

1995 • 67 citations

Attenuated influx of calcium ions at nerve endings of csp and shibire mutant Drosophila.

1998 • 66 citations

Cellugyrin, a Novel Ubiquitous Form of Synaptogyrin That Is Phosphorylated by pp60c-

1998 • 64 citations

Synaptic vesicles contain an ATP-dependent proton pump and show ‘knob-like’ protrusions on their surface.

1984 • 63 citations

Attenuated Influx of Calcium Ions at Nerve Endings ofcspandshibireMutantDrosophila

1998 • 54 citations

Acidification and endosome-like compartments in the presynaptic terminals of frog retinal photoreceptors

1989 • 41 citations

Synaptic plasticity

1998 • 28 citations