Synaptic Transmission Deficits inCaenorhabditis elegansSynaptobrevin Mutants

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

SNAP receptors implicated in vesicle targeting and fusion

1993 • 3,220 citations

Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences.

1991 • 3,108 citations

The synaptic vesicle cycle: a cascade of protein–protein interactions

1995 • 2,004 citations

A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion

1993 • 1,893 citations

Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin

1992 • 1,792 citations

Syntaxin: A Synaptic Protein Implicated in Docking of Synaptic Vesicles at Presynaptic Active Zones

1992 • 1,274 citations

Targeted expression of tetanus toxin light chain in Drosophila specifically eliminates synaptic transmission and causes behavioral defects

1995 • 921 citations

Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C

1990 • 829 citations

Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly.

1994 • 798 citations

[40] Immunofluorescence methods for yeast

1991 • 705 citations

Vesicle fusion from yeast to man

1994 • 635 citations

Toward a physical map of the genome of the nematode Caenorhabditis elegans

1986 • 631 citations

A modular set of lacZ fusion vectors for studying gene expression in Caenorhabditis elegans

1990 • 618 citations

VAMP-1: a synaptic vesicle-associated integral membrane protein.

1988 • 574 citations

Kinesin-related gene unc-104 is required for axonal transport of synaptic vesicles in C. elegans

1991 • 567 citations

Synaptic function is impaired but not eliminated in C. elegans mutants lacking synaptotagmin

1993 • 551 citations

Cell Membrane Resealing by a Vesicular Mechanism Similar to Neurotransmitter Release

1994 • 522 citations

Cellubrevin is a ubiquitous tetanus-toxin substrate homologous to a putative synaptic vesicle fusion protein

1993 • 504 citations

A genetic mapping system in Caenorhabditis elegans based on polymorphic sequence-tagged sites.

1992 • 487 citations

A genetic selection for Caenorhabditis elegans synaptic transmission mutants.

1996 • 449 citations

Genome linking with yeast artificial chromosomes

1988 • 438 citations

Syntaxin and synaptobrevin function downstream of vesicle docking in drosophila

1995 • 389 citations

Caenorhabditis elegans rab-3Mutant Synapses Exhibit Impaired Function and Are Partially Depleted of Vesicles

1997 • 373 citations

The Caenorhabditis elegans unc-17 Gene: a Putative Vesicular Acetylcholine Transporter

1993 • 361 citations

Effects of starvation and neuroactive drugs on feeding in Caenorhabditis elegans

1990 • 359 citations

Homologs of the synaptobrevin/VAMP family of synaptic vesicle proteins function on the late secretory pathway in S. cerevisiae

1993 • 316 citations

Caenorhabditis elegansLevamisole Resistance Geneslev-1,unc-29, andunc-38Encode Functional Nicotinic Acetylcholine Receptor Subunits

1997 • 315 citations

Binding of the synaptic vesicle v-SNARE, synaptotagmin, to the plasma membrane t-SNARE, SNAP-25, can explain docked vesicles at neurotoxin-treated synapses

1997 • 309 citations

SNAP-25, a t-SNARE which binds to both syntaxin and synaptobrevin via domains that may form coiled coils.

1994 • 288 citations

Botulinum neurotoxin serotype F is a zinc endopeptidase specific for VAMP/synaptobrevin

1993 • 283 citations

Interacting genes required for pharyngeal excitation by motor neuron MC in Caenorhabditis elegans.

1995 • 279 citations

A synaptic vesicle membrane protein is conserved from mammals to Drosophila

1989 • 272 citations

Levamisole-resitant mutants of the nematode Caenorhabditis elegans appear to lack pharmacological acetylcholine receptors

1980 • 271 citations

rbSec1A and B colocalize with syntaxin 1 and SNAP-25 throughout the axon, but are not in a stable complex with syntaxin.

1995 • 269 citations

A phorbol ester/diacylglycerol-binding protein encoded by the unc-13 gene of Caenorhabditis elegans.

1991 • 255 citations

A MOLECULAR DESCRIPTION OF SYNAPTIC VESICLE MEMBRANE TRAFFICKING

1994 • 248 citations

Electrical activity and behavior in the pharynx of caenorhabditis elegans

1994 • 224 citations

The C. elegans unc-104 4 gene encodes a putative kinesin heavy chain-like protein

1991 • 220 citations

Caenorhabditis elegans mutants resistant to inhibitors of acetylcholinesterase.

1995 • 211 citations

Botulinum G neurotoxin cleaves VAMP/synaptobrevin at a single Ala-Ala peptide bond.

1994 • 203 citations

Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities

2007 • 199 citations

A possible docking and fusion particle for synaptic transmission

1995 • 177 citations

Regulation of a periodic motor program in C. elegans

1994 • 158 citations

aex-3 Encodes a Novel Regulator of Presynaptic Activity in C. elegans

1997 • 156 citations

Identification and characterization of Drosophila genes for synaptic vesicle proteins

1993 • 149 citations

Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2.

1990 • 144 citations

Motor Neuron M3 Controls Pharyngeal Muscle Relaxation Timing in Caenorhabditis Elegans

1993 • 137 citations

SNC1, a yeast homolog of the synaptic vesicle-associated membrane protein/synaptobrevin gene family: genetic interactions with the RAS and CAP genes.

1992 • 133 citations

The C. elegans unc-18 gene encodes a protein expressed in motor neurons

1993 • 119 citations

The origin of footprints of the Tc1 transposon of Caenorhabditis elegans.

1991 • 111 citations

Mutational analysis of VAMP domains implicated in Ca2+-induced insulin exocytosis.

1996 • 100 citations

xo1-1 acts as an early switch in the C. elegans male/hermaphrodite decision

1995 • 98 citations

Genetic analysis of the cha-1-unc-17 gene complex in Caenorhabditis.

1989 • 82 citations

Cloning and characterization of the choline acetyltransferase structural gene (cha-1) from C. elegans

1994 • 81 citations

A 12-Residue-long Polyleucine Tail Is Sufficient to Anchor Synaptobrevin to the Endoplasmic Reticulum Membrane

1996 • 75 citations

Early aspects of Caenorhabditis elegans sex determination and dosage compensation are regulated by a zinc-finger protein

1991 • 64 citations

Chapter 11 Electrophysiological Methods

1995 • 64 citations

Effect of Mutations in Vesicle-Associated Membrane Protein (VAMP) on the Assembly of Multimeric Protein Complexes

1997 • 58 citations

Tetanus and Botulism Neurotoxins

1996 • 57 citations

Transposable element Tc1 of Caenorhabditis elegans recognizes specific target sequences for integration.

1988 • 53 citations

Cloning and properties of the Caenorhabditis elegans TATA-box-binding protein.

1993 • 25 citations

Genetic Analysis of Caenorhabditis elegans

1980 • 20 citations