Could treatment with scavengers of oxygen free radicals minimize complications in cardiac surgery?

Oxygen-Derived Free Radicals in Postischemic Tissue Injury

1985 • 5,488 citations

The stunned myocardium: prolonged, postischemic ventricular dysfunction.

1982 • 2,825 citations

The antioxidant action of N-acetylcysteine: Its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid

1989 • 1,769 citations

Myocardial reperfusion: a double-edged sword?

1985 • 1,355 citations

Mechanism for irreversible self-deactivation of prostaglandin synthetase.

1976 • 600 citations

Marked reduction of free radical generation and contractile dysfunction by antioxidant therapy begun at the time of reperfusion. Evidence that myocardial "stunning" is a manifestation of reperfusion injury.

1989 • 580 citations

Reperfusion injury and its pharmacologic modification.

1989 • 509 citations

A New Non-Thrombogenic Surface Prepared by Selective Covalent Binding of Heparin Via a Modified Reducing Terminal Residue

1983 • 437 citations

Free Radicals in Medicine. I. Chemical Nature and Biologic Reactions

1988 • 398 citations

Long-Lived Oxidants Generated by Human Neutrophils: Characterization and Bioactivity

1983 • 396 citations

Oxygen-derived free radicals and postischemic myocardial dysfunction (“stunned myocardium”)

1988 • 349 citations

Free Radicals in Medicine. II. Involvement in Human Disease

1988 • 344 citations

Acute myocardial dysfunction and recovery: A common occurrence after coronary bypass surgery

1990 • 322 citations

Occurrence of oxidative stress during reperfusion of the human heart.

1990 • 297 citations

Free radicals in biological systems—a review orientated to inflammatory processes

1987 • 235 citations

Liposome-mediated augmentation of superoxide dismutase in endothelial cells prevents oxygen injury.

1983 • 230 citations

The role of the neutrophil and free radicals in ischemic myocardial injury

1989 • 214 citations

Free radical-producing enzyme, xanthine oxidase, is undetectable in human hearts

1987 • 199 citations

Modulation of deferoxamine toxicity and clearance by covalent attachment to biocompatible polymers.

1989 • 185 citations

Mechanisms of oxidant injury of cells

1991 • 177 citations

Increased production of peroxidation products associated with cardiac operations

1986 • 175 citations

Reperfusion injury: laboratory artifact or clinical dilemma?

1986 • 174 citations

Superoxide production and reducing activity in human platelets.

1977 • 162 citations

Possible role for cytotoxic oxygen metabolites in the pathogenesis of cardiac ischemic injury.

1982 • 160 citations

A randomized controlled trial of allopurinol in coronary bypass surgery

1991 • 144 citations

Effects of supplementing hypothermic crystalloid cardioplegic solution with catalase, superoxide dismutase, allopurinol, or deferoxamine on functional recovery of globally ischemic and reperfused isolated hearts

1986 • 139 citations

The role of neutrophils and free radicals in the ischemic-reperfused heart: Why the confusion and controversy?

1989 • 129 citations

Prevention of reperfusion injury in the neonatal heart with leukocyte-depleted blood

1989 • 127 citations

Xanthine oxidase is not a source of free radicals in the ischemic rabbit heart

1987 • 127 citations

Vitamin E: Biochemistry and health implications

1990 • 125 citations

Prevention of free radical-induced myocardial reperfusion injury with allopurinol

1985 • 122 citations

Oxygen free radical generation during cardiopulmonary bypass: correlation with complement activation.

1986 • 114 citations

Is the autoxidation of catecholamines involved in ischemia-reperfusion injury?

1989 • 101 citations

Superoxide generation during cardiopulmonary bypass: Is there a role for vitamin E?

1986 • 96 citations

Influence of antioxidants (mannitol and allopurinol) on oxygen free radical generation during and after cardiopulmonary bypass.

1986 • 84 citations

Deferoxamine reduces neutrophil-mediated free radical production during cardiopulmonary bypass in man

1988 • 83 citations

Assessment of myocardial oxidative stress in patients after myocardial revascularization

1988 • 82 citations

Studies of controlled reperfusion after ischemia. XXI. Reperfusate composition: superiority of blood cardioplegia over crystalloid cardioplegia in limiting reperfusion damage--importance of endogenous oxygen free radical scavengers in red blood cells.

1991 • 78 citations

Hypercapnic acidosis and increased H2PO4- concentration do not decrease force in cat skeletal muscle

1991 • 69 citations

Studies of controlled reperfusion after ischemia

1991 • 65 citations

Existence and participation of xanthine oxidase in reperfusion injury of ischemic rabbit myocardium

1991 • 60 citations

Arachidonic acid metabolites and endothelial injury: studies with cultures of human endothelial cells.

1985 • 53 citations

In vivo infusion of oxygen free radical substrates causes myocardial systolic, but not diastolic dysfunction

1990 • 41 citations

Myocardial Protection with Blood Cardioplegia in Ischemically Injured Hearts: Reduction of Reoxygenation Injury with Allopurinol

1988 • 34 citations

Studies of controlled reperfusion after ischemia. XXII. Reperfusate composition: effects of leukocyte depletion of blood and blood cardioplegic reperfusates after acute coronary occlusion.

1991 • 32 citations

Influence of operations with cardiopulmonary bypass on polymorphonuclear leukocyte function in infants

1987 • 31 citations

Functional impairment in isolated rat hearts induced by activated leukocytes: Protective effect of oxygen free radical scavengers

1989 • 30 citations

Oxygen free radical producing leukocytes cause functional depression of isolated rat hearts: Role of leukotrienes

1990 • 30 citations

Studies of controlled reperfusion after ischemia

1991 • 25 citations

Granulocyte and eicosanoid gradients across the coronary circulation during myocardial reperfusion in cardiac surgery

1990 • 24 citations

Enhancement of cardioplegic protection with the free-radical scavenger peroxidase.

1986 • 21 citations

Studies of controlled reperfusion after ischemia

1991 • 19 citations

No evidence for reactive oxygen damage in ischemia-reflow injury.

1987 • 16 citations

Evidence for the presence of lipoxygenase pathway in cultured endothelial cells.

1983 • 14 citations

Leucocytes and cardiopulmonary bypass: in vitro production of oxygen free radicals and trapping in the reperfused myocardium

1990 • 13 citations

Recovery of the neonatal heart after normothermic ischemia. Effect of oxygen and catalase.

1991 • 7 citations

Recovery of the neonatal heart after normothermic ischemia

1991 • 7 citations

Influence of age on oxidative damage in mitochondria of ischemic and reperfused rat hearts.

1990 • 7 citations

Oxygen-derived free radical damage in canine heart transplantation

1989 • 7 citations

Age Related Differences in Oxygen Free Radical Injury during Myocardial Ischemia

1987 • 5 citations

Deleted Work

1955 • 0 citations