HYPERCOAGULABILITY IN CANCER

Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid

1983 • 3,942 citations

Mutation in blood coagulation factor V associated with resistance to activated protein C

1994 • 3,871 citations

Heparin-Induced Thrombocytopenia in Patients Treated with Low-Molecular-Weight Heparin or Unfractionated Heparin

1995 • 2,330 citations

Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C.

1993 • 1,997 citations

Hemostasis and Thrombosis: Basic Principles and Clinical Practice.

1988 • 1,817 citations

A Randomized Clinical Trial Evaluating Tamoxifen in the Treatment of Patients with Node-Negative Breast Cancer Who Have Estrogen-Receptor–Positive Tumors

1989 • 1,471 citations

Low molecular weight heparin

1992 • 921 citations

Very Low Doses of Warfarin Can Prevent Thrombosis in Central Venous Catheters

1990 • 805 citations

Central pulmonary thromboembolism: diagnosis with spiral volumetric CT with the single-breath-hold technique--comparison with pulmonary angiography.

1992 • 784 citations

Hemostasis and Thrombosis: Basic Principles and Clinical Practice

1994 • 723 citations

The Regulation of Natural Anticoagulant Pathways

1987 • 702 citations

Deep-Vein Thrombosis and the Incidence of Subsequent Symptomatic Cancer

1992 • 689 citations

Activation of blood coagulation in cancer: Trousseau's syndrome revisited

1983 • 676 citations

Trousseau's syndrome and other manifestations of chronic disseminated coagulopathy in patients with neoplasms: clinical, pathophysiologic, and therapeutic features.

1977 • 674 citations

Pulmonary Angiography, Ventilation Lung Scanning, and Venography for Clinically Suspected Pulmonary Embolism with Abnormal Perfusion Lung Scan

1983 • 666 citations

Low molecular weight heparin

1992 • 657 citations

Causes of death in cancer patients

1974 • 597 citations

Activation of blood coagulation in cancer: Trousseau's syndrome revisited

1983 • 590 citations

Is Embolic Risk Conditioned By Location of Deep Venous Thrombosis?

1981 • 577 citations

TROUSSEAUʼS SYNDROME AND OTHER MANIFESTATIONS OF CHRONIC DISSEMINATED COAGULOPATHY IN PATIENTS WITH NEOPLASMS

1977 • 547 citations

Molecular and Cellular Biology of Blood Coagulation

1992 • 539 citations

Double-blind randomised trial of very-low-dose warfarin for prevention of thromboembolism in stage IV breast cancer

1994 • 517 citations

An endothelial cell receptor for plasminogen/tissue plasminogen activator. I. Identity with annexin II.

1994 • 509 citations

Phlegmasia alba dolens.

1865 • 503 citations

The syndrome of hepatic veno-occlusive disease after marrow transplantation

1995 • 475 citations

The Relationship Between the Thrombotic and Infectious Complications of Central Venous Catheters

1994 • 465 citations

Bleeding and thrombosis in the myeloproliferative disorders

1984 • 428 citations

The Thrombogenic Effect of Anticancer Drug Therapy in Women with Stage II Breast Cancer

1988 • 424 citations

Venous and arterial thrombosis in patients who received adjuvant therapy for breast cancer.

1991 • 399 citations

VASCULAR OCCLUSIVE EPISODES AND VENOUS HÆMATOCRIT IN PRIMARY PROLIFERATIVE POLYCYTHÆMLX

1978 • 377 citations

Diagnostic Value of Ventilation-Perfusion Lung Scanning in Patients with Suspected Pulmonary Embolism

1985 • 375 citations

Serial Impedance Plethysmography for Suspected Deep Venous Thrombosis in Outpatients

1986 • 372 citations

Diagnostic Efficacy of Impedance Plethysmography for Clinically Suspected Deep-Vein Thrombosis

1985 • 355 citations

An endothelial cell receptor for plasminogen/tissue plasminogen activator (t-PA). II. Annexin II-mediated enhancement of t-PA-dependent plasminogen activation.

1994 • 341 citations

Budd-Chiari Syndrome

1982 • 328 citations

OCCLUSION OF THE HEPATIC VEINS IN MAN

1959 • 312 citations

Reassessing the hemostatic disorder associated with acute promyelocytic leukemia [see comments]

1992 • 306 citations

Primary Myeloproliferative Disorder and Hepatic Vein Thrombosis

1985 • 300 citations

Tumor Shedding and Coagulation

1981 • 291 citations

Carcinoma and Venous Thrombosis: The Frequency of Association of Carcinoma in the Body or Tail of the Pancreas with Multiple Venous Thrombosis

1938 • 287 citations

Complications and management of implanted venous access catheters.

1985 • 285 citations

Hemostatic alterations in cancer patients

1992 • 284 citations

Thromboregulation: multicellular modulation of platelet reactivity in hemostasis and thrombosis

1993 • 279 citations

Diagnosis of Deep-Vein Thrombosis Using Duplex Ultrasound

1989 • 278 citations

Role of plasma, platelets, and endothelial cells in tumor metastasis

1984 • 260 citations

Regulation of Extravascular Coagulation by Microvascular Permeability

1985 • 258 citations

Causes of death in cancer patients.

1975 • 254 citations

Abnormalities of PIG-A Transcripts in Granulocytes from Patients with Paroxysmal Nocturnal Hemoglobinuria

1994 • 249 citations

Superior vena cava thrombosis related to catheter malposition in cancer chemotherapy given through implanted ports

1993 • 239 citations

Etiology of portal vein thrombosis in adults

1988 • 236 citations

Vascular toxicity associated with antineoplastic agents.

1986 • 231 citations

Magnetic resonance venography for the detection of deep venous thrombosis: Comparison with contrast venography and duplex Doppler ultrasonography

1993 • 225 citations

Complications of indwelling venous access devices in cancer patients.

1995 • 220 citations

Hemostatic Abnormalities in Malignancy, a Prospective Study of One Hundred Eight Patients: Part I. Coagulation Studies

1979 • 218 citations

Isolation and characterization of cancer procoagulant: a cysteine proteinase from malignant tissue

1985 • 213 citations

Abnormalities of blood coagulation in patients with cancer. Mononuclear cell tissue factor generation.

1981 • 212 citations

Cancer procoagulant A: A factor X activating procoagulant from malignant tissue

1975 • 211 citations

Increased incidence of thromboembolism in stage IV breast cancer patients treated with a five-drug chemotherapy regimen

1984 • 202 citations

Hyperleukocytic leukemias: rheological, clinical, and therapeutic considerations

1982 • 194 citations

Elevated Plasma von Willebrand Factor Levels and Arterial Occlusive Complications Associated with Cisplatin-Based Chemotherapy

1985 • 189 citations

Hyperleukocytic leukemias: rheological, clinical, and therapeutic considerations

1982 • 186 citations

1992 ARRS Executive Council Award. Detection of deep venous thrombosis: prospective comparison of MR imaging with contrast venography.

1993 • 185 citations

Procoagulant activity associated with plasma membrane vesicles shed by cultured tumor cells.

1983 • 184 citations

A syndrome of thrombosis and hemorrhage complicating l-asparaginase therapy for childhood acute lymphoblastic leukemia

1982 • 179 citations

Occult Cancer in Patients with Acute Pulmonary Embolism

1982 • 175 citations

Occult cancer in patients with deep venous thrombosis. A systematic approach

1991 • 174 citations

The prethrombotic state in cancer.

1990 • 166 citations

Subclavian vein thrombosis in patients treated with infusion chemotherapy for advanced malignancy

1983 • 165 citations

Clinical Manifestations and Management of Inherited Thrombophilia: Retrospective Analysis and Follow-up after Diagnosis of 238 Patients with Congenital Deficiency of Antithrombin III, Protein C, Protein S

1994 • 162 citations

Pathways of Coagulation/Fibrinolysis Activation in Malignancy

1992 • 159 citations

Cachexia and the acute‐phase protein response in inflammation are regulated by interleukin‐6

1993 • 152 citations

Tissue factor as a tumor procoagulant

1992 • 152 citations

Occult Malignant Neoplasm in Patients With Deep Venous Thrombosis

1987 • 151 citations

Chemotherapy for breast cancer decreases plasma protein C and protein S.

1988 • 150 citations

Hypercoagulable States

1993 • 150 citations

Trousseau's syndrome. Devastating coagulopathy in the absence of heparin

1985 • 143 citations

A new procoagulant in acute leukemia

1988 • 128 citations

The activation of coagulation by extracts of mucus: a possible pathway of intravascular coagulation accompanying adenocarcinomas.

1973 • 127 citations

Prevention of Venous Thromboembolism

2008 • 124 citations

Long-term adjuvant therapy with tamoxifen: effects on sex hormone binding globulin and antithrombin III.

1987 • 124 citations

Idiopathic deep vein thrombosis in an apparently healthy patient as a premonitory sign of occult cancer

1986 • 122 citations

The effect of l-asparaginase on antithrombin, plasminogen, and plasma coagulation during therapy for acute lymphoblastic leukemia

1982 • 114 citations

Cancer procoagulant in human tumor cells: evidence from melanoma patients.

1986 • 113 citations

Local infusion of urokinase for the lysis of thrombosis associated with permanent central venous catheters in cancer patients.

1987 • 110 citations

Venous thrombosis as a side effect of tamoxifen treatment.

1984 • 107 citations

Significance of plasma fibrinopeptide A (fpA) in patients with malignancy.

1980 • 100 citations

Induction of tissue factor on monocytes by adhesion to endothelial cells.

1995 • 99 citations

Liver dysfunction rather than intravascular coagulation as the main cause of low protein C and antithrombin III in acute leukemia

1984 • 98 citations

Lectures on Clinical Medicine, Delivered at the Hotel-Dieu, Paris

2010 • 98 citations

Antigenic variation in cancer metastasis: immune escape versus immune control

1982 • 95 citations

The George E. Brown Memorial Lecture

1952 • 94 citations

Fibrinopeptide A in acute leukemia: relationship of activation of blood coagulation to disease activity

1981 • 92 citations

Hemostatic abnormalities in untreated cancer: incidence and correlation with thrombotic and hemorrhagic complications.

1987 • 90 citations

Naturally occurring anticoagulants and bone marrow transplantation: plasma protein C predicts the development of venocclusive disease of the liver

1993 • 89 citations

Spiral-computed tomography versus pulmonary angiography in the diagnosis of acute massive pulmonary embolism

1994 • 87 citations

Hypercoagulable states: molecular genetics to clinical practice

1994 • 86 citations

Erythromelalgia and Myeloproliferative Disorders

1989 • 86 citations

Further Studies on the Hypercoagulable State of Patients with Cushing’s Syndrome

1985 • 83 citations

Preliminary study to identify cancer patients at high risk of venous thrombosis following major surgery

1993 • 82 citations

The Veterans' Administration Cooperative Urological Research Group studies of carcinoma of the prostate: a review.

1975 • 82 citations

Antithrombin III depression and thrombin generation acceleration in women taking oral contraceptives

1971 • 82 citations

Therapeutic efficacy of autologous blood stem cell transplantation (ABSCT): the role of cytotoxic/cytokine stem cell mobilization.

1990 • 81 citations

Acquired protein C deficiency in patients with breast cancer receiving cyclophosphamide, methotrexate, and 5-fluorouracil

1989 • 80 citations

Tamoxifen treatment of metastatic breast cancer and antithrombin III levels

1984 • 80 citations

Fibrinopeptide A in acute leukemia: relationship of activation of blood coagulation to disease activity

1981 • 78 citations

The role of leukocytes in the activation of blood coagulation.

1992 • 78 citations

Platelet Contribution to the Formation of Metastatic Foci: The Role of Cancer Cell-Induced Platelet Activation

1988 • 76 citations

Liver dysfunction rather than intravascular coagulation as the main cause of low protein C and antithrombin III in acute leukemia

1984 • 75 citations

Alterations of Factor VIII von Willebrand Factor in Clinical Conditions Associated with an Increase in its Plasma Concentration

1981 • 71 citations

Human tumor procoagulants: registry of the Subcommittee on Haemostasis and Malignancy of the Scientific and Standardization Committee, International Society on Thrombosis and Haemostasis.

1993 • 68 citations

Fibrinopeptide A (FPA) Level and Fibrinogen Kinetics in Patients with Malignant Disease

1981 • 68 citations

The relationship between the thrombotic and infectious complications of central venous catheters

1994 • 67 citations

Guidelines for Clotting Studies in Cancer Patients

1993 • 63 citations

High frequency of antithrombin 3 and protein C deficiency following autologous bone marrow transplantation for lymphoma.

1991 • 62 citations

Hypercoagulability during <scp>l</scp>‐asparaginase treatment: the effect of antithrombin III supplementation in vivo

1990 • 60 citations

Greenfield filter instead of heparin as primary treatment for deep venous thrombosis or pulmonary embolism in patients with cancer

1992 • 57 citations

Cancer Procoagulant in Acute Non Lymphoid Leukemia: Relationship of Enzyme Detection to Disease Activity

1990 • 56 citations

Altered von Willebrand factor molecule in children with thrombosis following asparaginase-prednisone-vincristine therapy for leukemia.

1985 • 53 citations

Tumor necrosis factor alpha-induced endothelial tissue factor is located on the cell surface rather than in the subendothelial matrix

1994 • 53 citations

Cancer procoagulant in the human promyelocytic cell line NB4 and its modulation by all-trans-retinoic acid.

1994 • 51 citations

The hypercoagulable state in cancer patients

1994 • 51 citations

The diagnosis and treatment of thrombosis in the cancer patient.

1990 • 49 citations

Heparin in the prevention of infusion phlebitis. A double-blind controlled study.

1973 • 49 citations

Evidence of a Hypercoagulable State in Patients with Acute Lymphoblastic Leukemia Treated with Low Dose of E.coli L-Asparaginase: A GIMEMA Study

1993 • 48 citations

The influence of tamoxifen in vivo on the main natural anticoagulants and fibrinolysis

1993 • 48 citations

Mucin-producing adenocarcinomas and nonbacterial thrombotic endocarditis. Pathogenetic role of tumor mucin

1980 • 48 citations

Effects of tamoxifen on blood coagulation

1988 • 47 citations

Fibrinogen kinetics in patients with neoplastic disease

1978 • 47 citations

The influence of tamoxifen in vivo on the main natural anticoagulants and fibrinolysis

1993 • 47 citations

Use of Percutaneously Inserted Venous Catheters in Coronary Care Units

1972 • 46 citations

Antithrombin III Profiles in Malignancy, Relationship to Primary Tumors and Metastatic Sites

1981 • 45 citations

Human Tumor Procoagulants: Registry of the Subcommittee on Haemostasis and Malignancy of the Scientific and Standardization Committee, International Society on Thrombosis and Haemostasis

1993 • 41 citations

Occult malignant neoplasm in patients with deep venous thrombosis

1987 • 40 citations

Cancer procoagulant in acute lymphoblastic leukemia

1990 • 39 citations

Involvement of von willebrand factor in thrombosis following asparaginase‐prednisone‐vincristine therapy for leukemia

1987 • 37 citations

Hypercoagulability in patients undergoing autologous or allogeneic BMT for hematological malignancies.

1993 • 35 citations

Bleeding Problems in the Cancer Patient

1992 • 35 citations

Antithrombin III infusion suppresses the hypercoagulable state in adult acute lymphoblastic leukaemia patients treated with a low dose of Escherichia coli-asparaginase. A Gimema study

1994 • 34 citations

Von willebrand factor in head and neck cancer

1990 • 33 citations

Long-term adjuvant therapy with tamoxifen: Effects on sex hormone binding globulin and antithrombin III

1988 • 32 citations

Comparison of 125I-fibrinogen kinetics and fibrinopeptide A in patients with disseminated neoplasias

1982 • 31 citations

Clinical trials with anticoagulant and antiplatelet therapies

1992 • 26 citations

Binding of human factors X and Xa to HepG2 and J82 human tumor cell lines. Evidence that factor Xa binds to tumor cells independent of factor Va.

1990 • 26 citations

Cancer Cell Procoagulants and Their Implications

1992 • 25 citations

Protein C and S levels in acute leukemia

1991 • 25 citations

Diagnosis and Treatment of Recurrent Venous Thromboembolism

1984 • 25 citations

Clinical and Therapeutic Considerations in Nonbacterial Thrombotic Endocarditis

1973 • 24 citations

Studies on the pathogenesis of coagulopathy in patients with arterial thromboembolism and malignancy

1990 • 23 citations

Different Expression of Procoagulant Activity in Macrophages Associated with Experimental and Human Tumors

1988 • 21 citations

HLA-DR is a procoagulant

1991 • 21 citations

HEPARIN IN THE PREVENTION OF INFUSION PHLEBITIS

1974 • 19 citations

Hyperviscosity syndromes and coagulopathies.

1990 • 16 citations

Fibrinolytic agents in the treatment of thrombotic disorders.

1990 • 14 citations

Heparin in the prevention of infusion phlebitis. A double-blind controlled study

1973 • 13 citations

Effect of interferon alpha, interferon gamma and tumor necrosis factor on the procoagulant activity of human cancer cells.

1993 • 12 citations

Occult malignant neoplasm in patients with deep venous thrombosis

1987 • 12 citations

Erythromelalgia and myeloproliferative disorders

1989 • 7 citations