Increased cell surface expression and enhanced folding in the endoplasmic reticulum of a mutant erythropoietin receptor.

Human Growth Hormone and Extracellular Domain of Its Receptor: Crystal Structure of the Complex

1992 • 2,236 citations

Structural design and molecular evolution of a cytokine receptor superfamily.

1990 • 2,104 citations

Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive

1992 • 1,230 citations

Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure.

1987 • 949 citations

Human IL-3 (multi-CSF): Identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3

1986 • 823 citations

Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor.

1989 • 711 citations

A new cytokine receptor superfamily

1990 • 506 citations

Folding and Assembly of Viral Membrane Proteins

1993 • 447 citations

Homodimerization and constitutive activation of the erythropoietin receptor.

1992 • 326 citations

Friend spleen focus-forming virus glycoprotein gp55 interacts with the erythropoietin receptor in the endoplasmic reticulum and affects receptor metabolism.

1990 • 244 citations

Human erythropoietin receptor: cloning, expression, and biologic characterization

1990 • 242 citations

Erythropoietin receptor and interleukin-2 receptor β chain: A new receptor family

1989 • 208 citations

Activation and inhibition of erythropoietin receptor function: role of receptor dimerization.

1994 • 201 citations

The integrity of the conserved ‘WS motif’ common to IL-2 and other cytokine receptors is essential for ligand binding and signal transduction.

1991 • 130 citations

The gene for the human erythropoietin receptor: analysis of the coding sequence and assignment to chromosome 19p

1990 • 128 citations

Soluble aggregates of the human PiZ alpha 1-antitrypsin variant are degraded within the endoplasmic reticulum by a mechanism sensitive to inhibitors of protein synthesis.

1992 • 123 citations

Mutations in the Trp-Ser-X-Trp-Ser motif of the erythropoietin receptor abolish processing, ligand binding, and activation of the receptor.

1992 • 112 citations

Intracellular degradation of the transport-impaired human PiZ alpha 1-antitrypsin variant. Biochemical mapping of the degradative event among compartments of the secretory pathway.

1990 • 111 citations

[22] Iodine monochloride (ICI) iodination techniques

1983 • 95 citations

Mutational analysis of the ligand-binding domain of the prolactin receptor.

1991 • 84 citations

Intermediates in degradation of the erythropoietin receptor accumulate and are degraded in lysosomes

1993 • 75 citations

Mutations in the WSAWSE and Cytosolic Domains of the Erythropoietin Receptor Affect Signal Transduction and Ligand Binding and Internalization

1992 • 69 citations

Activation and Inhibition of Erythropoietin Receptor Function: Role of Receptor Dimerization

1994 • 53 citations