Glutamine: recent developments in research on the clinical significance of glutamine

Physiological actions of taurine

1992 • 2,555 citations

The prevalence of nosocomial infection in intensive care units in Europe. Results of the European Prevalence of Infection in Intensive Care (EPIC) Study. EPIC International Advisory Committee

1995 • 2,104 citations

The Prevalence of Nosocomial Infection in Intensive Care Units in Europe

1995 • 1,469 citations

Multiple Organ Failure Pathophysiology and Potential Future Therapy

1992 • 1,398 citations

Intestinal permeability: An overview

1995 • 940 citations

Glutathione deficiency produced by inhibition of its synthesis, and its reversal; Applications in research and therapy

1991 • 906 citations

INCREASED MORTALITY ASSOCIATED WITH GROWTH HORMONE TREATMENT IN CRITICALLY ILL ADULTS

1999 • 894 citations

Serum Cytokine Levels in Human Septic Shock

1993 • 882 citations

Glutamine supplementation in serious illness: A systematic review of the evidence*

2002 • 727 citations

Randomised trial of glutamine-enriched enteral nutrition on infectious morbidity in patients with multiple trauma

1998 • 633 citations

POST-INJURY MULTIPLE ORGAN FAILURE: THE ROLE OF THE GUT

2001 • 538 citations

Six-month outcome of critically ill patients given glutamine-supplemented parenteral nutrition

1997 • 534 citations

Glutamine metabolism in lymphocytes of the rat

1983 • 442 citations

Organ dysfunction after cardiopulmonary bypass. A systemic inflammatory reaction initiated by the extracorporeal circuit

1987 • 350 citations

Decreased mortality and infectious morbidity in adult burn patients given enteral glutamine supplements: A prospective, controlled, randomized clinical trial*

2003 • 298 citations

Parenteral l-alanyl-l-glutamine improves 6-month outcome in critically ill patients*

2002 • 286 citations

Glutamine Preserves Liver Glutathione After Lethal Hepatic Injury

1992 • 258 citations

Role of osmoregulation in the actions of taurine

2000 • 241 citations

Glutamine induces heat shock protein and protects against endotoxin shock in the rat

2001 • 238 citations

Regulative potential of glutamine—relation to glutathione metabolism

2002 • 220 citations

Intestinal Cytokine Response After Gut Ischemia

1999 • 219 citations

T<scp>ROPHIC AND</scp> C<scp>YTOPROTECTIVE</scp> N<scp>UTRITION FOR</scp> I<scp>NTESTINAL</scp> A<scp>DAPTATION</scp>, M<scp>UCOSAL</scp> R<scp>EPAIR, AND</scp> B<scp>ARRIER</scp> F<scp>UNCTION</scp>

2003 • 204 citations

The effect of supplemental enteral glutamine on plasma levels, gut function, and outcome in severe burns: a randomized, double‐blind, controlled clinical trial

2003 • 203 citations

Taurine chloramine, a product of activated neutrophils, inhibits in vitro the generation of nitric oxide and other macrophage inflammatory mediators

1995 • 200 citations

Glutamine delays spontaneous apoptosis in neutrophils

2003 • 175 citations

Glutamine Metabolism in Sepsis and Infection

2001 • 164 citations

Nutritional and Metabolic Aspects of Glutathione

1989 • 164 citations

Glutamine attenuates post-traumatic glutathione depletion in human muscle

2003 • 161 citations

Glutamine Protects Activated Human T Cells from Apoptosis by Up-Regulating Glutathione and Bcl-2 Levels

2002 • 159 citations

Infection, multiple organ failure, and survival in the intensive care unit: influence of glutamine-supplemented parenteral nutrition on acquired infection

2002 • 151 citations

Effect of free glutamine and alanyl-glutamine dipeptide on mucosal proliferation of the human ileum and colon

1994 • 149 citations

Glutamine attenuates tumor necrosis factor-α release and enhances heat shock protein 72 in human peripheral blood mononuclear cells

2002 • 138 citations

Effect of a glutamine-enriched enteral diet on intestinal permeability and infectious morbidity at 28 days in critically ill patients with Systemic Inflammatory Response Syndrome

2002 • 132 citations

A prospective randomized trial of enteral glutamine in critical illness

2003 • 127 citations

Importance of glutamine metabolism in murine macrophages and human monocytes to L-arginine biosynthesis and rates of nitrite or urea production

1998 • 126 citations

The Metabolic Response to Injury and Its Nutritional Implications: Retrospect and Prospect

1979 • 123 citations

Metabolic fate of glutamine in lymphocytes, macrophages and neutrophils

1999 • 123 citations

Influence of glutamine on the phenotype and function of human monocytes

1995 • 119 citations

Modulating effect of glutamine on IL-1β-induced cytokine production by human gut

2003 • 115 citations

Glutamine-enriched Intravenous Feedings Attenuate Extracellular Fluid Expansion After a Standard Stress

1991 • 113 citations

Glutamine Enhances Gut Glutathione Production

1998 • 109 citations

Standardized parenteral alanyl-glutamine dipeptide supplementation is not beneficial in autologous transplant patients: a randomized, double-blind, placebo controlled study

2002 • 108 citations

Enteral glutamine supplementation and morbidity in low birth weight infants

2003 • 100 citations

Oral Feeding With Glutamine Prevents Lymphocyte and Glutathione Depletion of Peyer’s Patches in Endotoxemic Mice

2001 • 97 citations

Glutamine deprivation facilitates tumour necrosis factor induced bacterial translocation in Caco-2 cells by depletion of enterocyte fuel substrate

2003 • 97 citations

Preoperative Glutamine Administration Induces Heat-Shock Protein 70 Expression and Attenuates Cardiopulmonary Bypass–Induced Inflammatory Response by Regulating Nitric Oxide Synthase Activity

2002 • 94 citations

Glutamine and the gastrointestinal tract

2000 • 91 citations

Supplemental glutamine augments phagocytosis and reactive oxygen intermediate production by neutrophils and monocytes from postoperative patients in vitro

2000 • 89 citations

Skeletal Muscle Glutathione After Surgical Trauma

1996 • 85 citations

Closed Head Injury in the Rat Induces Whole Body Oxidative Stress: Overall Reducing Antioxidant Profile

1999 • 84 citations

Is glutamine beneficial in ischemic heart disease? 1 1Guest Editor: Gil Hardy, PhD

2002 • 84 citations

Glutathione deficiency increases organ dysfunction after hemorrhagic shock.

1992 • 82 citations

Glutamine attenuates post-traumatic glutathione depletion in human muscle

2003 • 80 citations

Glutamine depletion impairs cellular stress response in human leucocytes

2002 • 76 citations

Enteral Nutrition Prevents Remote Organ Injury and Death After a Gut Ischemic Insult

2001 • 74 citations

Glutamine-Enriched Enteral Nutrition Increases HLA-DR Expression on Monocytes of Trauma Patients

2002 • 72 citations

Glutamine preserves protein synthesis and paracellular permeability in Caco-2 cells submitted to ”luminal fasting“

2003 • 71 citations

Review: Glutamine and Nucleotide Metabolism Within Enterocytes

1998 • 62 citations

Renal transport of taurine adapts to perturbed taurine homeostasis.

1982 • 59 citations

Glutamine preserves cardiomyocyte viability and enhances recovery of contractile function after ischemia‐reperfusion injury

2003 • 59 citations

Postoperative glycyl-glutamine infusion reduces immunosuppression: partial prevention of the surgery induced decrease in HLA-DR expression on monocytes

2001 • 57 citations

Glutamine Supplementation and Deprivation: Effect on Artificially Reared Rat Small Intestinal Morphology

2002 • 52 citations

Participation of nitric oxide in the mucosal injury of rat intestine induced by ischemia-reperfusion.

1998 • 52 citations

Total parenteral nutrition supplementation with glutamine improves survival after gut ischemia/reperfusion

2002 • 47 citations

The effect of glutamine-supplemented total parenteral nutrition on nitrogen economy depends on severity of diseases in surgical patients

2002 • 45 citations

The Relationship between Plasma Taurine and Other Amino Acid Levels in Human Sepsis

2000 • 44 citations

Gut-Associated Lymphoid Tissue

1994 • 42 citations

Effects of adrenaline on glucose and glutamine metabolism and superoxide production by rat neutrophils

1999 • 40 citations

Combined growth hormone/insulin-like growth factor I in addition to glutamine-supplemented TPN results in net protein anabolism in critical illness

2004 • 39 citations

Plasma taurine concentrations increase after enteral glutamine supplementation in trauma patients and stressed rats

2003 • 37 citations

The role of glutamine, serum and energy factors in growth of enterocyte-like cell lines

1998 • 32 citations

The Protective Effect of Taurine on the Biomembrane Against Damage Produced by the Oxygen Radical

1992 • 30 citations

Glutamine infusion during ischemia is detrimental in a murine gut ischemia/reperfusion model

2003 • 29 citations

Function of renal γ-glutamyltransferase: Significance of glutathione and glutamine interactions

1982 • 28 citations

ORGAN SPECIFIC FORMATION OF NITROSYL COMPLEXES UNDER INTESTINAL ISCHEMIA/REPERFUSION IN RATS INVOLVES NOS-INDEPENDENT MECHANISM(S)

2001 • 28 citations

Glutamine Reduces Phorbol‐12,13‐Dibutyrate‐Induced Macromolecular Hyperpermeability in HT‐29Cl.19A Intestinal Cells

1999 • 25 citations

Glutamine-enriched enteral nutrition increases in vitro interferon-gamma production but does not influence the in vivo specific antibody response to KLH after severe trauma. A prospective, double blind, randomized clinical study

2004 • 24 citations

Glutamine Improves Impaired Cellular Exudation and Polymorphonuclear Neutrophil Phagocytosis Induced by Total Parenteral Nutrition After Glycogen-Induced Murine Peritonitis

2003 • 20 citations

Oral glutamine does not prevent bacterial translocation in rats subjected to intestinal obstruction and Escherichia coli challenge but reduces systemic bacteria spread

2002 • 20 citations

Glutamine starvation of monocytes inhibits the ubiquitin–proteasome proteolytic pathway

2003 • 19 citations

The effect of glutamine on inducible nitric oxide synthase gene expression in intestinal ischemia-reperfusion injury

2003 • 12 citations

Bench to Bedside Nitric Oxide in Emergency Medicine

2000 • 10 citations

Myocardial self-preservative effect of heat shock protein 70 on an immature lamb heart

1999 • 9 citations