Serotonylation of Small GTPases Is a Signal Transduction Pathway that Triggers Platelet α-Granule Release

Synthesis of Serotonin by a Second Tryptophan Hydroxylase Isoform

2003 • 1,478 citations

Transglutaminases: Nature’s biological glues

2002 • 1,004 citations

Transglutaminases: multifunctional cross‐linking enzymes that stabilize tissues

1991 • 999 citations

Molecular mechanisms of platelet activation.

1989 • 903 citations

Defective platelet activation in Gαq-deficient mice

1997 • 566 citations

Primary Structure of the Human Platelet Serotonin Uptake Site: Identity with the Brain Serotonin Transporter

1993 • 543 citations

Gln 63 of Rho is deamidated by Escherichia coli cytotoxic necrotizing factor-1

1997 • 531 citations

A mouse model of severe von Willebrand disease: Defects in hemostasis and thrombosis

1998 • 512 citations

Serotonin transporter overexpression is responsible for pulmonary artery smooth muscle hyperplasia in primary pulmonary hypertension

2001 • 506 citations

Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen

2000 • 490 citations

Modern views on an ancient chemical: serotonin effects on cell proliferation, maturation, and apoptosis

2001 • 486 citations

Serotonin transporter overexpression is responsible for pulmonary artery smooth muscle hyperplasia in primary pulmonary hypertension

2001 • 450 citations

Signaling events underlying thrombus formation

2003 • 374 citations

Inhibitory Role of the Endothelium in the Response of Isolated Coronary Arteries to Platelets

1983 • 353 citations

Stimulated platelets use serotonin to enhance their retention of procoagulant proteins on the cell surface

2002 • 317 citations

CNF1 Exploits the Ubiquitin-Proteasome Machinery to Restrict Rho GTPase Activation for Bacterial Host Cell Invasion

2002 • 284 citations

Platelet Dense Granules

1999 • 274 citations

Tissue Transglutaminase and Apoptosis: Sense and Antisense Transfection Studies with Human Neuroblastoma Cells

1994 • 253 citations

Crystalline Serotonin

1948 • 249 citations

Tissue transglutaminase and apoptosis: sense and antisense transfection studies with human neuroblastoma cells.

1994 • 183 citations

Rho GTPases as Targets of Bacterial Protein Toxins

2000 • 167 citations

Platelet Inhibition by Sertraline and N-Desmethylsertraline: A Possible Missing Link Between Depression, Coronary Events, and Mortality Benefits of Selective Serotonin Reuptake Inhibitors

2001 • 164 citations

Tissue Transglutaminase Mediates Activation of RhoA and MAP Kinase Pathways during Retinoic Acid-induced Neuronal Differentiation of SH-SY5Y Cells

2002 • 152 citations

Tissue transglutaminase is essential for neurite outgrowth in human neuroblastoma SH-SY5Y cells

2001 • 118 citations

Activation of Rho through a cross-link with polyamines catalyzed by Bordetella dermonecrotizing toxin

2000 • 111 citations

Small GTPase Rab4 Regulates Ca2+-induced α-Granule Secretion in Platelets

2000 • 105 citations

5-Hydroxytryptamine drives apoptosis in biopsylike Burkitt lymphoma cells: reversal by selective serotonin reuptake inhibitors

2002 • 94 citations

Activation of the small GTPases, rac and cdc42, after ligation of the platelet PAR-1 receptor

2000 • 90 citations

Role of transglutaminase II in retinoic acid-induced activation of RhoA-associated kinase-2

2001 • 84 citations

Serotonin Deficiency and Prolonged Bleeding in Beige Mice

1976 • 79 citations

Immunoneutralization of Glycoprotein Ibα Attenuates Endotoxin-Induced Interactions of Platelets and Leukocytes With Rat Venular Endothelium In Vivo

2000 • 76 citations

Is the serotonin transporter involved in the pathogenesis of pulmonary hypertension?

2002 • 75 citations

Identification of the C-terminal Part of BordetellaDermonecrotic Toxin as a Transglutaminase for Rho GTPases

1999 • 72 citations

RhoA Sustains Integrin αIIbβ3Adhesion Contacts under High Shear

2002 • 70 citations

EFFECT OF FENFLURAMINE ON 5‐HYDROXYTRYPTAMINE UPTAKE AND RELEASE BY RAT BLOOD PLATELETS

1975 • 65 citations

Thrombospondin and fibrinogen bind serotonin-derivatized proteins on COAT-platelets

2002 • 63 citations

Catalytic properties of a calmodulin-regulated transglutaminase from human platelet and chicken gizzard.

1985 • 63 citations

The Vesicular Monoamine Content Regulates VMAT2 Activity through Gαq in Mouse Platelets

2003 • 62 citations

Kinetic Analysis of the Action of Tissue Transglutaminase on Peptide and Protein Substrates

2003 • 53 citations

“Tissue” transglutaminase and apoptosis

1998 • 50 citations

Serotonin synthesis in murine embryonic stem cells

1999 • 41 citations

Tissue-transglutaminase in rat and human brain: light and electron immunocytochemical analysis and in situ hybridization study

2001 • 41 citations

Adenosine Nucleotides and Serotonin Stimulate von Wille-brand Factor Release from Cultured Human Endothelial Cells

1994 • 34 citations

Thrombin-Induced Activation of RhoA in Platelet Shape Change

2001 • 29 citations

Small GTPase Rho Regulates Thrombin-Induced Platelet Aggregation

2001 • 27 citations

Serotonin-induced secretion of von Willebrand factor from human umbilical vein endothelial cells via the cyclic AMP-signaling systems independent of increased cytoplasmic calcium concentration

1999 • 25 citations

Platelet-vessel wall interactions in hemostasis: Implication of 5-hydroxytryptamine

1984 • 22 citations

Characterization of human platelets separated from blood by ADP-induced aggregation.

1975 • 18 citations

Regulation of the dual function tissue transglutaminase/Gαh during murine neuromuscular development: gene and enzyme isoform expression

2000 • 17 citations

Activation of the 2A –adrenoceptor mediates deceleration of the deaggregation component of the response to ADP or 5-HT in human platelets in vitro

2001 • 16 citations

Deaggregation is an integral component of the response of platelets to ADP in vitro : kinetic studies of literature and original data

2001 • 13 citations

Transient Expression of Transglutaminase C During Prenatal Development of Human Muscles

2000 • 11 citations

Characterization of rat platelet serotonin receptors with tryptamine agonists and the antagonists: Ketanserin and SCH 23390

1991 • 6 citations

The effect of fenfluramine on collagen‐induced platelet aggregation in vitro.

1983 • 5 citations