Platelet Inhibition by Sertraline and N-Desmethylsertraline: A Possible Missing Link Between Depression, Coronary Events, and Mortality Benefits of Selective Serotonin Reuptake Inhibitors

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1988 • 3,403 citations

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1988 • 1,973 citations

Depression Following Myocardial Infarction

1993 • 1,958 citations

Depression and 18-Month Prognosis After Myocardial Infarction

1995 • 1,594 citations

Depression and the Course of Coronary Artery Disease

1998 • 685 citations

Exaggerated platelet reactivity in major depression

1996 • 575 citations

Biobehavioral variables and mortality or cardiac arrest in the Cardiac Arrhythmia Pilot Study (CAPS)

1990 • 444 citations

Zur Serotonin-Hypothese der Depression*

1990 • 397 citations

Major depressive disorder in coronary artery disease

1987 • 364 citations

Elevated platelet factor 4 and β-thromboglobulin plasma levels in depressed patients with ischemic heart disease

1997 • 349 citations

Rapid Platelet-Function Assay

1999 • 267 citations

Abciximab (ReoPro, Chimeric 7E3 Fab) Demonstrates Equivalent Affinity and Functional Blockade of Glycoprotein IIb/IIIa and α _v β ₃ Integrins

1998 • 264 citations

Decreased uptake of 5-hydroxytryptamine in blood platelets from depressed patients

1976 • 251 citations

Pharmacokinetic-Pharmacodynamic Relationship of the Selective Serotonin Reuptake Inhibitors???

1996 • 212 citations

Platelet 5-hydroxytryptamine accumulation in depressive illness

1978 • 196 citations

Potential Vascular and Bleeding Complications of Treatment With Selective Serotonin Reuptake Inhibitors

1996 • 178 citations

Characterization of an In Vitro Platelet Function Analyzer, PFA-100™

1996 • 177 citations

Serotonin 5-HT2 receptor binding on blood platelets - a peripheral marker for depression?

1987 • 170 citations

Effects of serotonin on platelet activation in whole blood

1997 • 168 citations

Clinical overview of serotonin reuptake inhibitors.

1990 • 166 citations

An open-label preliminary trial of sertraline for treatment of major depression after acute myocardial infarction (the SADHAT Trial)

1999 • 161 citations

Effects of Serotonin on Platelets and Blood Vessels

1991 • 157 citations

Effects of Reteplase and Alteplase on Platelet Aggregation and Major Receptor Expression During the First 24 Hours of Acute Myocardial Infarction Treatment

1998 • 143 citations

New insights into the mechanisms of platelet adhesion and aggregation.

1994 • 130 citations

Sertraline: a new antidepressant.

1988 • 122 citations

Comparison of Antiplatelet Effects of Aspirin, Ticlopidine, or Their Combination After Stent Implantation

1998 • 120 citations

Platelet serotonergic indices in major depression: up-regulation of 5-HT2A receptors unchanged by antidepressant treatment

1997 • 108 citations

Modification of serotonergic neuron properties by long-term treatment with serotonin reuptake blockers.

1990 • 106 citations

Flow Cytometric Measurement of Platelet Function and Reticulated Platelets

1993 • 101 citations

Platelet-Derived Serotonin, the Endothelium, and Cardiovascular Disease

1991 • 83 citations

Phenytoin in Wound Healing

1996 • 78 citations

The Platelet Serotonergic System in Depression and Following Sertraline Treatment

1988 • 74 citations

Abnormal Platelet Aggregation Associated with Fluoxetine Therapy

1992 • 68 citations

Platelet serotonin markers and depressive symptomatology

1995 • 68 citations

Discussion

1999 • 64 citations

Factors Influencing Platelet Aggregation in Whole Blood

1986 • 63 citations

Preclinical pharmacology of sertraline: A potent and specific inhibitor of serotonin reuptake.

1990 • 63 citations

Ultrastructural Studies of Platelet Aggregates From Human Subjects Receiving Clopidogrel and From a Patient With an Inherited Defect of an ADP-Dependent Pathway of Platelet Activation

1996 • 62 citations

Bruising Associated with the Use of Fluoxetine

1996 • 59 citations

Heterogeneity of platelet aggregation and major surface receptor expression in patients with acute myocardial infarction

1998 • 56 citations

Blood coagulation and platelet aggregation in major depression

1996 • 53 citations

Modulation of Platelet-neutrophil Interaction with Pharmacological Inhibition of Fibrinogen Binding to Platelet GPIIb/IIIa Receptor

1999 • 53 citations

Serotonin-induced increases in platelet cytosolic calcium concentration in depressed, schizophrenic, and substance abuse patients

1996 • 51 citations

Effects of Serotonin Reuptake Inhibitors on Hemostasis

1996 • 51 citations

Different Effects of Calcium Antagonists, Nitrates, and β-Blockers on Platelet Function

1997 • 50 citations

Forskolin-stimulated platelet adenylyl cyclase activity is lower in persons with major depression

1997 • 48 citations

Role of thromboxane and serotonin as mediators in the development of spontaneous alterations in coronary blood flow and neointimal proliferation in canine models with chronic coronary artery stenoses and endothelial injury

1991 • 44 citations

Dietary Coenzyme Q10 Supplementation Alters Platelet Size and Inhibits Human Vitronectin (CD51/CD61) Receptor Expression

1997 • 42 citations

Platelet Cytosolic Calcium Responses to Serotonin in Depressed Patients and Controls: Relationship to Symptomatology and Medication

1998 • 39 citations

[3H]-Imipramine binding in human platelets: A new biochemical parameter in depression

1980 • 39 citations

Preclinical pharmacology of sertraline: a potent and specific inhibitor of serotonin reuptake.

1990 • 35 citations

Elevated [ 3 H]inositol 1,4,5-trisphosphate binding sites and expressed inositol 1,4,5-trisphosphate receptor protein level in platelets of depressed patients

1998 • 28 citations

Platelet imidazoline receptors and regulatory G proteins in patients with major depression

1996 • 23 citations

The effect of clinical outcome on platelet G proteins of major depressed patients

1998 • 23 citations

Alteration by a plasma factor(s) of platelet aggregation in unmedicated unipolar depressed patients

1994 • 22 citations

Platelet monoamine oxidase activity in elderly depressed outpatients

1986 • 22 citations

Effects of Fluoxetine and Norfluoxetine on 5-Hydroxytryptamine Metabolism in Blood Platelets and Brain after Administration to Rats

1998 • 22 citations

Platelet monoamine oxidase activity in patients with winter seasonal affective disorder

1996 • 22 citations

Classification of patients with affective disorders using platelet monoamine oxidase activity, serum melatonin and post‐dexamethasone Cortisol

1995 • 20 citations

Further characterization of the inhibition of platelet aggregation by a plasma factor(s) in unmedicated unipolar depressed patients

1995 • 20 citations

Alteration by a plasma factor of platelet aggregation and 5HT uptake in depression

1992 • 18 citations

Adrenaline-Induced Platelet Aggregation in Depressed Patients and Control Subjects

1993 • 18 citations

Baseline Platelet Aggregation and Major Receptor Expression Predict Subsequent Activity Following Thrombolysis for Acute Myocardial Infarction

2000 • 13 citations

[Antithrombocytic effectiveness of magnesium].

1996 • 8 citations