Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines

Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation

1995 • 1,960 citations

GROWTH FACTOR RECEPTOR TYROSINE KINASES

1988 • 1,841 citations

Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth Factor

1995 • 906 citations

Fetal Anemia and Apoptosis of Red Cell Progenitors in Stat5a−/−5b−/− Mice

1999 • 710 citations

A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations

1991 • 606 citations

Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors

1995 • 596 citations

Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. A study on a large series of patients and cell lines

1997 • 462 citations

Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product

1998 • 456 citations

Suppression of interleukin-3-induced gene expression by a C-terminal truncated Stat5: role of Stat5 in proliferation.

1996 • 414 citations

Transcriptional regulation of the cyclin D1 promoter by STAT5: its involvement in cytokine-dependent growth of hematopoietic cells

1999 • 341 citations

Receptor tyrosine kinases

1992 • 271 citations

Platelet-Derived Growth Factor Induces Phosphorylation of Multiple JAK Family Kinases and STAT Proteins

1996 • 247 citations

Tandem duplications of the FLT3 receptor gene are associated with leukemic transformation of myelodysplasia

1997 • 207 citations

Mitogenic signalling and substrate specificity of the Flk2/Flt3 receptor tyrosine kinase in fibroblasts and interleukin 3-dependent hematopoietic cells.

1993 • 174 citations

IL-3 dependent regulation of Bcl-xL gene expression by STAT5 in a bone marrow derived cell line

1999 • 157 citations

Isolation and chromosomal localization of a novel FMS-like tyrosine kinase gene

1991 • 153 citations

Constitutive activation of mitogen-activated protein kinase pathway in acute leukemia cells

1997 • 147 citations

Flt3 ligand stimulates proliferation and inhibits apoptosis of acute myeloid leukemia cells: regulation of Bcl-2 and Bax

1996 • 145 citations

Interleukin-3 regulates the activity of the LYN protein-tyrosine kinase in myeloid-committed leukemic cell lines

1992 • 128 citations

Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells

1999 • 118 citations

Resistance of Paroxysmal Nocturnal Hemoglobinuria Cells to the Glycosylphosphatidylinositol-Binding Toxin Aerolysin

1999 • 102 citations

FLT3 signaling in hematopoietic cells involves CBL, SHC and an unknown P115 as prominent tyrosine-phosphorylated substrates

1998 • 97 citations

Effects of human FLT3 ligand on myeloid leukemia cell growth: heterogeneity in response and synergy with other hematopoietic growth factors

1995 • 87 citations

Activation of Stat5 by platelet-derived growth factor (PDGF) is dependent on phosphorylation sites in PDGF β-receptor juxtamembrane and kinase insert domains

1998 • 85 citations

Differential constitutive activation between STAT‐related proteins and MAP kinase in primary acute myelogenous leukaemia

1998 • 75 citations

The role of MAP kinase kinase in interleukin-3 stimulation of proliferation

1996 • 56 citations

IMMUNOHISTOCHEMICAL DETECTION OF p53 PROTEIN OVEREXPRESSION VERSUS GENE SEQUENCING IN URINARY BLADDER CARCINOMAS

1999 • 52 citations

Effects of flt3 ligand on acute myeloid and lymphocytic leukemic blast cells from children.

1996 • 50 citations

The CBL-related Protein CBLB Participates in FLT3 and Interleukin-7 Receptor Signal Transduction in Pro-B Cells

1998 • 50 citations

Mitogenic Signalling and Substrate Specificity of the Flk2/Flt3 Receptor Tyrosine Kinase in Fibroblasts and Interleukin 3-Dependent Hematopoietic Cells

1993 • 40 citations

Human FLT3/FLK2 gene: cDNA cloning and expression in hematopoietic cells

1993 • 37 citations

Lyn Physically Associates With the Erythropoietin Receptor and May Play a Role in Activation of the Stat5 Pathway

1998 • 15 citations

Book Review

1996 • 2 citations