IL-3 dependent regulation of Bcl-xL gene expression by STAT5 in a bone marrow derived cell line

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

1997 • 2,245 citations

Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation

1995 • 1,960 citations

PI3K: Downstream AKTion Blocks Apoptosis

1997 • 1,693 citations

STATs: Signal Transducers and Activators of Transcription

1996 • 1,414 citations

Cytokine signal transduction

1994 • 1,358 citations

Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses

1998 • 1,316 citations

Stat5a is mandatory for adult mammary gland development and lactogenesis.

1997 • 1,106 citations

Choice of STATs and Other Substrates Specified by Modular Tyrosine-Based Motifs in Cytokine Receptors

1995 • 992 citations

Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression

1997 • 989 citations

Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

1994 • 813 citations

Two Signals Are Necessary for Cell Proliferation Induced by a Cytokine Receptor gp130: Involvement of STAT3 in Anti-Apoptosis

1996 • 661 citations

Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha.

1992 • 661 citations

Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs.

1995 • 641 citations

Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription.

1994 • 599 citations

Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue.

1995 • 556 citations

Requirement for MAP Kinase (ERK2) Activity in Interferon α- and Interferon β-Stimulated Gene Expression Through STAT Proteins

1995 • 549 citations

Bcl-2 Phosphorylation Required for Anti-apoptosis Function

1997 • 540 citations

CIS, a Cytokine Inducible SH2 Protein, Is a Target of the JAK-STAT5 Pathway and Modulates STAT5 Activation

1997 • 538 citations

A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain.

1995 • 531 citations

Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins

1993 • 504 citations

Contribution of STAT SH2 Groups to Specific Interferon Signaling by the Jak-STAT pathway

1995 • 428 citations

Suppression of interleukin-3-induced gene expression by a C-terminal truncated Stat5: role of Stat5 in proliferation.

1996 • 414 citations

STAT3β, a Splice Variant of Transcription Factor STAT3, Is a Dominant Negative Regulator of Transcription

1996 • 378 citations

Prolactin, growth hormone, erythropoietin and granulocyte-macrophage colony stimulating factor induce MGF-Stat5 DNA binding activity.

1995 • 374 citations

Jak-STAT Signaling Induced by the v- abl oncogene

1995 • 341 citations

Interleukin-3 signals through multiple isoforms of Stat5.

1995 • 327 citations

Suppression of apoptotic death in hematopoietic cells by signalling through the IL-3/GM-CSF receptors.

1995 • 321 citations

Constitutive activation of JAKs and STATs in BCR-Abl-expressing cell lines and peripheral blood cells derived from leukemic patients.

1997 • 283 citations

Deletion of the Carboxyl-Terminal Transactivation Domain of MGF-Stat5 Results in Sustained DNA Binding and a Dominant Negative Phenotype

1996 • 276 citations

Erythropoietin Induces Activation of Stat5 through Association with Specific Tyrosines on the Receptor That Are Not Required for a Mitogenic Response

1996 • 272 citations

Naturally Occurring Dominant Negative Variants of Stat5

1996 • 270 citations

Components of a stat recognition code: Evidence for two layers of molecular selectivity

1995 • 254 citations

Bcl-2-independent Bcr–Abl-mediated resistance to apoptosis: protection is correlated with up regulation of Bcl-xL

1998 • 238 citations

Mouse oncostatin M: an immediate early gene induced by multiple cytokines through the JAK-STAT5 pathway.

1996 • 224 citations

Interleukin 2 and erythropoietin activate STAT5/MGF via distinct pathways.

1995 • 224 citations

Thrombopoietin activates a STAT5-like factor in hematopoietic cells.

1995 • 218 citations

Identification of tyrosine residues within the intracellular domain of the erythropoietin receptor crucial for STAT5 activation.

1996 • 206 citations

Different interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation.

1996 • 202 citations

Signals through gp130 upregulate bcl-x gene expression via STAT1-binding cis-element in cardiac myocytes.

1997 • 201 citations

Activation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interleukin 2 receptor beta chain but is not essential for the proliferative signal transmission.

1995 • 190 citations

Genomic organization, promoter region analysis, and chromosome localization of the mouse bcl-x gene.

1997 • 188 citations

STAT5A-Deficient Mice Demonstrate a Defect in Granulocyte-Macrophage Colony-Stimulating Factor–Induced Proliferation and Gene Expression

1997 • 180 citations

Mediation of Growth Hormone-dependent Transcriptional Activation by Mammary Gland Factor/Stat 5

1995 • 169 citations

Expression of Bcl-2, Bcl-x, and Bax after T cell activation and IL-2 withdrawal.

1995 • 167 citations

A Sequence of the CIS Gene Promoter Interacts Preferentially with Two Associated STAT5A Dimers: a Distinct Biochemical Difference between STAT5A and STAT5B

1998 • 160 citations

Functionally Distinct Isoforms of STAT5 Are Generated by Protein Processing

1997 • 155 citations

Functional Differences between Stat3α and Stat3β

1997 • 145 citations

Interleukin-3, Erythropoietin, and Prolactin Activate a STAT5-like Factor in Lymphoid Cells

1995 • 128 citations

Comparison of the Transactivation Domains of Stat5 and Stat6 in Lymphoid Cells and Mammary Epithelial Cells

1997 • 126 citations

Regulation of mammary gland factor/Stat5a during mammary gland development.

1995 • 119 citations

Elf-1 and Stat5 Bind to a Critical Element in a New Enhancer of the Human Interleukin-2 Receptor α Gene

1996 • 117 citations

Role of PI3-kinase in Bcl-X induction and apoptosis inhibition mediated by IL-3 or IGF-1 in Baf-3 cells

1999 • 92 citations

Regulation of Cell Growth by IL-2: Role of STAT5 in Protection from Apoptosis But Not in Cell Cycle Progression

1998 • 90 citations

STAT5 Activation Correlates with Erythropoietin Receptor-mediated Erythroid Differentiation of an Erythroleukemia Cell Line

1997 • 90 citations

Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response.

1995 • 90 citations

Carboxyl-Truncated STAT5β Is Generated by a Nucleus-Associated Serine Protease in Early Hematopoietic Progenitors

1998 • 87 citations

Erythropoietin-induced erythroid differentiation of the human erythroleukemia cell line TF-1 correlates with impaired STAT5 activation.

1996 • 83 citations

Activation of the Jak2-Stat5 Signaling Pathway in Nb2 Lymphoma Cells by an Anti-apoptotic Agent, Aurintricarboxylic Acid

1998 • 79 citations

Mitogen-activated protein kinase kinase inhibition decreases growth hormone stimulated transcription mediated by STAT5

1997 • 61 citations

In bone marrow derived Baf-3 cells, inhibition of apoptosis by IL-3 is mediated by two independent pathways

1997 • 56 citations

STATs as activators of apoptosis

1998 • 51 citations

STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients

1996 • 44 citations

Cytokine regulation of apoptosis in hematopoietic precursor cells

1996 • 38 citations

v-Abl protein tyrosine kinase (PTK) mediated suppression of apoptosis is associated with the up-regulation of Bcl-XL

1997 • 31 citations

Bcl-X is the major pleiotropic anti-apoptotic gene activated by retroviral insertion mutagenesis in an IL-3 dependent bone marrow derived cell line

1998 • 24 citations

BCR-ABL and constitutively active erythropoietin receptor (cEpoR) activate distinct mechanisms for growth factor-independence and inhibition of apoptosis in Ba/F3 cell line

1998 • 23 citations

Carboxyl-Truncated STAT5β Is Generated by a Nucleus-Associated Serine Protease in Early Hematopoietic Progenitors

1998 • 10 citations

K

1995 • 1 citations