Endothelial exposure to hypoxia induces Egr‐1 expression involving PKCα‐mediated Ras/Raf‐1/ERK1/2 pathway

Regulatory Functions of the Vascular Endothelium

1990 • 1,899 citations

Protein kinase Cα activates RAF-1 by direct phosphorylation

1993 • 1,282 citations

Inhibition of NIH 3T3 Cell Proliferation by a Mutant ras Protein with Preferential Affinity for GDP

1988 • 757 citations

Ternary complex factors: growth factor regulated transcriptional activators

1994 • 686 citations

Stimulation of the Stress-Activated Mitogen-Activated Protein Kinase Subfamilies in Perfused Heart

1996 • 531 citations

Imaging of Phosphorescence: A Novel Method for Measuring Oxygen Distribution in Perfused Tissue

1988 • 526 citations

Egr-1-Induced Endothelial Gene Expression: A Common Theme in Vascular Injury

1996 • 525 citations

Raf-1 protein kinase is required for growth of induced NIH/3T3 cells

1991 • 489 citations

Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP.

1988 • 470 citations

Requirement of Ras-GTP-Raf Complexes for Activation of Raf-1 by Protein Kinase C

1998 • 437 citations

Perspectives on Oxygen Sensing

1999 • 376 citations

The oxygen dependence of mitochondrial oxidative phosphorylation measured by a new optical method for measuring oxygen concentration.

1988 • 374 citations

ENDOTHELIAL CELL RESPONSES TO HYPOXIC STRESS

1999 • 371 citations

Fluid shear stress modulates cytosolic free calcium in vascular endothelial cells

1992 • 355 citations

Identification of neutral active phospholipase C which hydrolyzes choline glycerophospholipids and plasmalogen selective phospholipase A2 in canine myocardium.

1985 • 315 citations

High-level expression of Egr-1 and Egr-1–inducible genes in mouse and human atherosclerosis

2000 • 293 citations

Role of Diacylglycerol-Regulated Protein Kinase C Isotypes in Growth Factor Activation of the Raf-1 Protein Kinase

1997 • 292 citations

Activation of the c-Raf protein kinase by protein kinase C phosphorylation.

1992 • 288 citations

Interplay of Sp1 and Egr-1 in the Proximal Platelet-derived Growth Factor A-Chain Promoter in Cultured Vascular Endothelial Cells

1995 • 278 citations

The stress-activated protein kinases are major c-Jun amino-terminal kinases activated by ischemia and reperfusion

1994 • 266 citations

Intracellular Ca2+ pool content is linked to control of cell growth.

1993 • 260 citations

Novel Roles of Specific Isoforms of Protein Kinase C in Activation of the c-fos Serum Response Element

1999 • 255 citations

Promoter Sequences of the Human Transforming Growth Factor-β1 Gene Responsive to Transforming Growth Factor-β1 Autoinduction

1989 • 254 citations

Hypoxia-associated Induction of Early Growth Response-1 Gene Expression

1999 • 250 citations

Cyclic Strain–Induced Monocyte Chemotactic Protein-1 Gene Expression in Endothelial Cells Involves Reactive Oxygen Species Activation of Activator Protein 1

1997 • 246 citations

Calibration of Oxygen-Dependent Quenching of the Phosphorescence of Pd-meso-tetra (4-Carboxyphenyl) Porphine: A Phosphor with General Application for Measuring Oxygen Concentration in Biological Systems

1996 • 244 citations

Reactive Oxygen Species Are Involved in Shear Stress-Induced Intercellular Adhesion Molecule-1 Expression in Endothelial Cells

1997 • 197 citations

Fluid shear stress activation of egr-1 transcription in cultured human endothelial and epithelial cells is mediated via the extracellular signal-related kinase 1/2 mitogen-activated protein kinase pathway.

1998 • 196 citations

Differential translocation of protein kinase C isozymes by thrombin and platelet-derived growth factor. A possible function for phosphatidylcholine-derived diacylglycerol

1993 • 182 citations

Stimulation of c-Jun Kinase and Mitogen-Activated Protein Kinase by Ischemia and Reperfusion in the Perfused Rat Heart

1996 • 180 citations

Tissue factor transcription driven by Egr-1 is a critical mechanism of murine pulmonary fibrin deposition in hypoxia

1998 • 180 citations

Egr-1 Mediates Extracellular Matrix-driven Transcription of Membrane Type 1 Matrix Metalloproteinase in Endothelium

1999 • 179 citations

Hypoxia/Reoxygenation Stimulates Jun Kinase Activity Through Redox Signaling in Cardiac Myocytes

1997 • 179 citations

A Novel Mechanism of JNK1 Activation

1997 • 171 citations

Transcriptional Regulation of the Tissue Factor Gene in Human Epithelial Cells Is Mediated by Sp1 and EGR-1

1996 • 160 citations

Muscarinic Receptor Activation of Phosphatidylcholine Hydrolysis

1989 • 146 citations

Hypoxia alters the subcellular distribution of protein kinase C isoforms in neonatal rat ventricular myocytes.

1997 • 145 citations

Effect of hypoxia upon intracellular calcium concentration of human endothelial cells

1992 • 140 citations

Hypoxia Induces c-fos Transcription via a Mitogen-activated Protein Kinase-dependent Pathway

1997 • 140 citations

Hydrolysis of phosphatidylcholine couples Ras to activation of Raf protein kinase during mitogenic signal transduction.

1993 • 135 citations

Hypoxia potentiates nitric oxide synthesis and transiently increases cytosolic calcium levels in pulmonary artery endothelial cells

1995 • 132 citations

Hypoxia and Hypoxia/Reoxygenation Activate p65PAK, p38Mitogen-Activated Protein Kinase (MAPK), and Stress-Activated Protein Kinase (SAPK) in Cultured Rat Cardiac Myocytes

1997 • 124 citations

Modulation of Ras/Raf/Extracellular Signal–Regulated Kinase Pathway by Reactive Oxygen Species Is Involved in Cyclic Strain–Induced Early Growth Response-1 Gene Expression in Endothelial Cells

1999 • 123 citations

Mechanical Strain Induces Monocyte Chemotactic Protein-1 Gene Expression in Endothelial Cells

1995 • 122 citations

PKC-ε Is Required for Mechano-sensitive Activation of ERK1/2 in Endothelial Cells

1997 • 122 citations

Protein Kinase C Regulates Integrin-induced Activation of the Extracellular Regulated Kinase Pathway Upstream of Shc

1999 • 115 citations

Phorbol diesters stimulate the accumulation of phosphatidate, phosphatidylethanol, and diacylglycerol in three cell types. Evidence for the indirect formation of phosphatidylcholine-derived diacylglycerol by a phospholipase D pathway and direct formation of diacylglycerol by a phospholipase C pathway.

1990 • 113 citations

5' upstream sequence and genomic structure of the human primary response gene, EGR-1/TIS8.

1991 • 112 citations

Nitric Oxide Regulates Shear Stress–Induced Early Growth Response-1

1999 • 107 citations

Protein Kinase C η Mediates Lipopolysaccharide-induced Nitric-oxide Synthase Expression in Primary Astrocytes

1998 • 106 citations

Inducible PDGF A-chain transcription in smooth muscle cells is mediated by Egr-1 displacement of Sp1 and Sp3

1997 • 98 citations

Negative Modulation of Membrane Localization of the Raf-1 Protein Kinase by Hyperphosphorylation

1997 • 70 citations

Acute hypoxia increases cytosolic calcium in fetal pulmonary artery smooth muscle cells

1993 • 61 citations

Nitric Oxide–Mediated Augmentation of Polymorphonuclear Free Radical Generation After Hypoxia-Reoxygenation

1999 • 58 citations

Phosphatidylcholine-specific Phospholipase C Regulates Thapsigargin-induced Calcium Influx in Human Lymphocytes

1997 • 30 citations

Hypoxia and Molecular Cardiovascular Medicine

1998 • 17 citations

Role of calcium in the progression of renal disease: experimental evidence.

1992 • 15 citations

Effects of Anoxia on Intracellular Free Ca2+ in Isolated Cardiomyocytes From Turtles

1997 • 8 citations