The secretases that cleave angiotensin converting enzyme and the amyloid precursor protein are distinct from tumour necrosis factor‐α convertase

Phase separation of integral membrane proteins in Triton X-114 solution.

1981 • 3,366 citations

A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells

1997 • 3,094 citations

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α

1997 • 1,608 citations

Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor

1990 • 1,388 citations

A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: Ramifications for the complex physiology of TNF

1988 • 1,105 citations

Membrane protein secretases

1997 • 634 citations

A rapid method for the preparation of microvilli from rabbit kidney

1974 • 608 citations

Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing

1994 • 607 citations

MUTANT GENES IN FAMILIAL ALZHEIMER'S DISEASE AND TRANSGENIC MODELS

1998 • 576 citations

Processing of the β‐Amyloid Precursor Protein and Its Regulation in Alzheimer's Disease

1995 • 431 citations

Crystal structure of the catalytic domain of human tumor necrosis factor-α-converting enzyme

1998 • 376 citations

Metalloprotease-Disintegrins: Links to Cell Adhesion and Cleavage of TNFα and Notch

1997 • 363 citations

Generation of amyloid β protein from its precursor is sequence specific

1995 • 260 citations

ADAMs in Fertilization and Development

1996 • 259 citations

Isolation of two differentially glycosylated forms of peptidyl-dipeptidase A (angiotensin converting enzyme) from pig brain: a re-evaluation of their role in neuropeptide metabolism

1987 • 190 citations

Pig kidney angiotensin converting enzyme. Purification and characterization of amphipathic and hydrophilic forms of the enzyme establishes C-terminal anchorage to the plasma membrane

1987 • 132 citations

Alzheimer's Amyloid Precursor Protein α-Secretase Is Inhibited by Hydroxamic Acid-Based Zinc Metalloprotease Inhibitors: Similarities to the Angiotensin Converting Enzyme Secretase

1998 • 122 citations

Non-amyloidogenic cleavage of the beta-amyloid precursor protein by an integral membrane metalloendopeptidase.

1994 • 112 citations

Characterization of a secretase activity which releases angiotensin-converting enzyme from the membrane

1993 • 111 citations

Cell Surface Localization of Proteolysis of Human Endothelial Angiotensin I-converting Enzyme

1995 • 60 citations

Angiotensin-converting enzyme secretase is inhibited by zinc metalloprotease inhibitors and requires its substrate to be inserted in a lipid bilayer

1997 • 52 citations

Transmembrane kit ligand cleavage does not require a signal in the cytoplasmic domain and occurs at a site dependent on spacing from the membrane.

1994 • 44 citations

Structural Requirements for the Ectodomain Cleavage of Human Cell Surface Macrophage Colony-stimulating Factor

1996 • 22 citations

Nonrandom Integration of Human U4 RNA Pseudogenes

1985 • 13 citations