The effects of Ca2+ and calmodulin on adenylyl cyclase activity in plasma membranes derived from neural and non-neural cells

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

A highly sensitive adenylate cyclase assay

1974 • 4,213 citations

Isolation of an organ specific protein antigen from cell-surface membrane rat liver

1968 • 883 citations

Protein kinase C phosphorylates the inhibitory guanine‐nucleotide‐binding regulatory component and apparently suppresses its function in hormonal inhibition of adenylate cyclase

1985 • 736 citations

Expression and characterization of calmodulin-activated (type I) adenylylcyclase

1991 • 435 citations

Protein activator of cyclic 3′:5′-nucleotide phosphodiesterase of bovine or rat brain also activates its adenylate cyclase

1975 • 361 citations

Activation of calmodulin by various metal cations as a function of ionic radius.

1984 • 336 citations

Platelets in biology and pathology

1977 • 308 citations

[46] Clonal strains of hormone-producing pituitary cells

1979 • 296 citations

Effect of trypsin on the exposed polypeptides and glycoproteins in the human platelet membrane

1972 • 269 citations

Modulation of adenylate cyclase of human platelets by phorbol ester

1985 • 225 citations

Correlation between cytosolic free Ca2+ and insulin release in an insulin-secreting cell line.

1984 • 199 citations

Characterization of the adrenergic receptors mediating a rise in cyclic 3'-5'-adenosine monophosphate in rat cerebral cortex.

1973 • 184 citations

Interesting and useful biochemical properties of lanthanides

1983 • 175 citations

Inositol trisphosphate mediates thyrotropin-releasing hormone mobilization of nonmitochondrial calcium in rat mammotropic pituitary cells.

1984 • 168 citations

Vasoactive intestinal peptide (VIP) stimulates prolactin (PRL) release and cAMP production in a rat pituitary cell line (GH3/B6). Additive effects of VIP and TRH on PRL release

1979 • 160 citations

Cell culture in the neurosciences

1986 • 127 citations

Regulation of adenylate cyclase from glial tumor cells by calcium and a calcium-binding protein.

1976 • 124 citations

Thyrotropin releasing hormone

1982 • 124 citations

K‐Opiate Agonists Inhibit Adenylate Cyclase and Produce Heterologous Desensitization in Rat Spinal Cord

1989 • 119 citations

Calmodulin regulation of adenylate cyclase activity

1985 • 116 citations

Ca2+-dependent regulation of guinea pig brain adenylate cyclase.

1980 • 114 citations

PC12 Cells as a Model of Neuronal Differentiation

1985 • 110 citations

Interactive properties of calmodulin

1988 • 110 citations

The multifunctional Ca2+/calmodulin-dependent protein kinase.

1988 • 99 citations

Rat brain adenylate cyclase

1977 • 81 citations

Inositol 1,4,5-trisphosphate and intracellular Ca2+ homeostasis in clonal pituitary cells (GH3). Translocation of Ca2+ into mitochondria from a functionally discrete portion of the nonmitochondrial store.

1986 • 80 citations

Calcium as intracellular messenger: sensitivity modulation, C-kinase pathway, and sustained cellular response.

1984 • 79 citations

Pertussis toxin blocks the inhibitory effects of somatostatin on cAMP-dependent vasoactive intestinal peptide and cAMP-independent thyrotropin releasing hormone-stimulated prolactin secretion of GH3 cells.

1986 • 78 citations

Stimulation of Adenylate Cyclase by Ca2+ and Calmodulin in Rat Islets of Langerhans: Explanation for the Glucose-induced Increase in Cyclic AMP Levels

1980 • 77 citations

Thyroliberin receptor binding and adenylyl cyclase activation in cultured prolactin-producing rat pituitary tumor cells (GH cells).

1983 • 72 citations

Regulation of vasopressin-sensitive adenylate cyclase by calmodulin.

1981 • 69 citations

The role of calcium ions in accumulation of cyclic adenosine monophosphate elicited by alpha and beta adrenergic agonists in rat brain slices.

1977 • 69 citations

Functional epithelial cell line cloned from rat parathyroid glands.

1987 • 66 citations

Monoclonal antibodies against various forms of the adenylyl cyclase catalytic subunit and associated proteins

1991 • 62 citations

Calcium inhibition of cardiac adenylyl cyclase. Evidence for two distinct sites of inhibition

1991 • 60 citations

Synergism between histamine H1- and H2-receptors in the cAMP response in guinea pig brain slices: effects of phorbol esters and calcium.

1988 • 59 citations

The role of calcium in the regulation of cyclic nucleotide levels in brain slices of rat and guinea pig

1978 • 56 citations

Synergistic activation of brain adenylate cyclase by calmodulin, and either GTP or catecholamines including dopamine

1990 • 55 citations

Growth Hormone-Releasing Factor-Sensitive Adenylate Cyclase System of Purified Somatotrophs: Effects of Guanine Nucleotides, Somatostatin, Calcium, and Magnesium*

1989 • 52 citations

CALCIUM AND CAMP IN STIMULUS‐RESPONSE COUPLING*

1980 • 52 citations

Synergistic activation of brain adenylate cyclase by calmodulin, and either GTP or catecholamines including dopamine

1991 • 51 citations

Calmodulin stimulation and calcium regulation of smooth muscle adenylate cyclase activity.

1983 • 48 citations

Calmodulin plays a dominant role in determining neurotransmitter regulation of neuronal adenylate cyclase

1988 • 44 citations

Regulation of Dopamine Release from PC12 Pheochromocytoma Cell Cultures During Stimulation with Elevated Potassium or Carbachol

1985 • 35 citations

Antagonism of calmodulin-stimulated adenylate cyclase by trifluoperazine, calmidazolium and W-7 in rat cerebellar membranes.

1987 • 34 citations

Calcium-dependent adenylate cyclase of pituitary tumor cells

1982 • 33 citations

EVIDENCE FOR CALMODULIN SENSITIVE ADENYLATE CYCLASE IN BOVINE ADRENAL MEDULLA*

1980 • 32 citations

Regulation of Calmodulin-sensitive Adenylate Cyclase by the Stimulatory G-protein, Gs

1989 • 32 citations

Potent and cooperative feedback inhibition of adenylate cyclase activity by calcium in pituitary-derived GH3 cells

1990 • 31 citations

Calmodulin activation of adenylate cyclase in the mouse B16 melanoma

1984 • 28 citations

5-Hydroxytryptamine receptor agonists influence calcium-stimulated adenylate cyclase activity in the cerebral cortex and hippocampus of the rat

1990 • 28 citations

CALCIUM, CYCLIC AMP AND HORMONE ACTION

1985 • 28 citations

On the role of extracellular Ca2+ for prolactin release and adenosine 3′:5′-monophosphate formation induced by thyroliberin in cultured rat pituitary cells

1980 • 28 citations

Assay of calmodulin with Bordetella pertussis adenylate cyclase

1982 • 26 citations

Differential effects of Ca2+-calmodulin on adenylate cyclase activity cyclase activity in mouse and rat pancreatic islets

1982 • 25 citations

Cellular control through interactions between cyclic nucleotides and calcium.

1984 • 25 citations

Biphasic Ca2+ response of adenylate cyclase. The role of calmodulin in its activation by Ca2+ ions

1986 • 25 citations

Phorbol ester treatment impairs hormone‐ but not stable GTP analog‐induced inhibition of adenylate cyclase

1986 • 24 citations

Calcium and calmodulin in the regulation of human thyroid adenylate cyclase activity

1985 • 24 citations

Role of Calmodulin in the Effect of Guanyl Nucleotides on Rat Hippocampal Adenylate Cyclase: Involvement of Adenosine and Opiates

1983 • 23 citations

Calmodulin may play a pivotal role in neurotransmitter-mediated inhibition and stimulation of rat cerebellar adenylate cyclase.

1987 • 23 citations

Calmodulin‐Dependent Phosphatases of PC12, GH₃, and C₆ Cells: Physical, Kinetic, and Immunochemical Properties

1987 • 20 citations

Phorbol esters increase adenylate cyclase activity and stability in pituitary membranes

1988 • 20 citations

Interaction of the Inhibitory GTP Regulatory Component with Soluble Cerebral Cortical Adenylate Cyclase

1986 • 19 citations

Involvement of calmodulin in the regulation of adenylate cyclase activity in guinea-pig enterocytes

1983 • 19 citations

Relationship Among Calmodulin‐, Forskolin‐, and Guanine Nucleotide‐Dependent Adenylate Cyclase Activities in Cerebellar Membranes: Studies by Limited Proteolysis

1985 • 18 citations

Calmodulin stimulation of the rat cerebral cortical adenylate cyclase is required for the detection of guanine nucleotide- or hormone-mediated inhibition.

1987 • 18 citations

Evaluation of methods for the isolation of plasma membranes displaying guanosine 5′-triphosphate-dependence for the regulation of adenylate cyclase activity: Potential application to the study of other guanosine 5′-triphosphate-dependent transduction systems

1988 • 16 citations

No Role for Phospholipase A₂ and Protein Kinase C in the Potentiation by α‐Adrenoceptors of β‐Adrenoceptor‐Mediated Cyclic AMP Formation in Rat Brain

1989 • 15 citations

Calcium Dependence of Somatostatin (SRIF) Release and Cyclic AMP Levels in Cultured Diencephalic Neurons

1989 • 13 citations

Calmodulin regulation of adenylate cyclase activity in human platelet membranes

1986 • 6 citations

Interactions between Neurotransmitters that Regulate cAMP and Intracellular Ca2+ Levels in the CNS

1988 • 4 citations