Pertussis toxin blocks the inhibitory effects of somatostatin on cAMP-dependent vasoactive intestinal peptide and cAMP-independent thyrotropin releasing hormone-stimulated prolactin secretion of GH3 cells.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone

1973 • 3,509 citations

Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain.

1984 • 1,300 citations

An ultrasensitive method for the simultaneous determination of cyclic AMP and cyclic GMP in small-volume samples from blood and tissue

1977 • 679 citations

Somatostatin: Hypothalamic Inhibitor of the Endocrine Pancreas

1974 • 519 citations

Specific uncoupling by islet-activating protein, pertussis toxin, of negative signal transduction via alpha-adrenergic, cholinergic, and opiate receptors in neuroblastoma x glioma hybrid cells.

1983 • 493 citations

Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin

1984 • 418 citations

ADP-ribosylation of the specific membrane protein by islet-activating protein, pertussis toxin, associated with inhibition of a chemotactic peptide-induced arachidonate release in neutrophils. A possible role of the toxin substrate in Ca2+-mobilizing biosignaling.

1984 • 389 citations

Guanine nucleotide-binding regulatory proteins and dual control of adenylate cyclase.

1984 • 342 citations

Modification by islet-activating protein of receptor-mediated regulation of cyclic AMP accumulation in isolated rat heart cells.

1981 • 326 citations

[46] Clonal strains of hormone-producing pituitary cells

1979 • 296 citations

Thyrotropin-releasing hormone rapidly activates the phosphodiester hydrolysis of polyphosphoinositides in GH3 pituitary cells. Evidence for the role of a polyphosphoinositide-specific phospholipase C in hormone action.

1983 • 292 citations

A nucleotide regulatory site for somatostatin inhibition of adenylate cyclase in S49 lymphoma cells

1983 • 200 citations

Islet-activating protein. Enhanced insulin secretion and cyclic AMP accumulation in pancreatic islets due to activation of native calcium ionophores.

1979 • 193 citations

Vasoactive intestinal peptide (VIP) stimulates prolactin (PRL) release and cAMP production in a rat pituitary cell line (GH3/B6). Additive effects of VIP and TRH on PRL release

1979 • 160 citations

Association of the N-formyl-Met-Leu-Phe receptor in human neutrophils with a GTP-binding protein sensitive to pertussis toxin.

1985 • 159 citations

Thyrotropin-Releasing Hormone (TRH) Stimulates Biphasic Elevation of Cytoplasmic Free Calcium in GH₃Cells. Further Evidence that TRH Mobilizes Cellular and Extracellular Ca²⁺*

1985 • 143 citations

Inhibition of Adrenocorticotropin Secretion by Somatostatin in Pituitary Cells in Culture*

1981 • 136 citations

Evidence for the Role of Calcium and Diacylglycerol as Dual Second Messengers in Thyrotropin-Releasing Hormone Action: Involvement of Diacylglycerol*

1984 • 132 citations

Separation and purification of the hemagglutinins from Bordetella pertussis

1983 • 132 citations

The Somatostatin Receptor Is Directly Coupled to Adenylate Cyclase in GH4Ci Pituitary Cell Membranes*

1984 • 130 citations

Characteristics of the Interaction Between Thyrotropin-Releasing Hormone and Somatostatin for Thyrotropin and Prolactin Release

1976 • 116 citations

Thyrotropin-Releasing Hormone (TRH) Selectively and Rapidly Stimulates Phosphatidylinositol Turnover in GH Pituitary Cells: A Possible Second Step of TRH Action*

1982 • 105 citations

Bombesin Stimulates Prolactin and Growth Hormone Release by Pituitary Cells in Culture*

1982 • 104 citations

Islet‐activating protein, pertussis toxin, inhibits Ca²⁺‐induced and guanine nucleotide‐dependent releases of histamine and arachidonic acid from rat mast cells

1984 • 96 citations

Somatostatin lowers the cytosolic free Ca2+ concentration in clonal rat pituitary cells (GH3 cells)

1984 • 81 citations

Evidence for the Role of Calcium and Diacylglycerol as Dual Second Messengers in Thyrotropin-Releasing Hormone Action: Involvement of Ca⁺²*

1984 • 76 citations

Evidence that Stimulation of Thyrotropin and Prolactin Secretion by Thyrotropin-Releasing Hormone Occur via Different Calcium-Mediated Mechanisms: Studies with Verapamil*

1982 • 75 citations

Inhibition of Gastrin Release by Somatostatin in Vitro

1975 • 73 citations

Regulation of thyrotropin-releasing hormone binding by monovalent cations and guanyl nucleotides.

1984 • 72 citations

Release of Growth Hormone from Purified Somatotrophs: Use of Perifusion System to Elucidate Interrelations among Ca⁺⁺, Adenosine 3',5'-Monophosphate, and Somatostatin*

1982 • 69 citations

Modulation of somatostatin receptors by thyrotropin-releasing hormone in a clonal pituitary cell strain.

1980 • 68 citations

Thyrotropin-releasing hormone stimulates GTP hydrolysis by membranes from GH4C1 rat pituitary tumor cells.

1984 • 62 citations

Regulation of Ca2+-dependent cyclic AMP accumulation and Ca2+ metabolism in intact pituitary tumor cells by modulators of prolactin production.

1983 • 43 citations

The relationship between pertussis-toxin-induced ADP-ribosylation of a plasma-membrane protein and reversal of muscarinic inhibition of prolactin secretion in GH3 cells

1984 • 26 citations

Pertussis toxin blocks the inhibitory effect of muscarinic cholinergic agonists on cyclic AMP accumulation and prolactin secretion in GH3 anterior-pituitary tumour cells

1984 • 25 citations

The inhibitory guanine nucleotide-binding regulatory subunit of adenylate cyclase has an adenylate cyclase-independent modulatory effect on ACTH secretion from mouse pituitary tumor cells

1985 • 17 citations