A Critical Evaluation of Nonmammalian Models for Aging Research

Initial sequencing and comparative analysis of the mouse genome

2002 • 6,971 citations

Finishing the euchromatic sequence of the human genome

2004 • 4,741 citations

Cell Death

2004 • 4,599 citations

Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

2003 • 2,209 citations

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ

2004 • 1,896 citations

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

2001 • 1,892 citations

Calorie Restriction Promotes Mammalian Cell Survival by Inducing the SIRT1 Deacetylase

2004 • 1,877 citations

Sirtuin activators mimic caloric restriction and delay ageing in metazoans

2004 • 1,847 citations

Comparative Genomics of the Eukaryotes

2000 • 1,688 citations

The Draft Genome of Ciona intestinalis : Insights into Chordate and Vertebrate Origins

2002 • 1,611 citations

Evidence for a clade of nematodes, arthropods and other moulting animals

1997 • 1,581 citations

The retardation of aging and disease by dietary restriction

1989 • 1,494 citations

Longevity, senescence and the genome

1995 • 1,390 citations

Molecular phylogenetics and the origins of placental mammals

2001 • 1,372 citations

The Endocrine Regulation of Aging by Insulin-like Signals

2003 • 1,342 citations

Sir2 mediates longevity in the fly through a pathway related to calorie restriction

2004 • 1,337 citations

Handbook of the Biology of Aging

1990 • 1,219 citations

Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans

2002 • 1,150 citations

Unified nomenclature for the winged helix/forkhead transcription factors

2000 • 1,136 citations

Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises

2003 • 1,057 citations

The genetics of caloric restriction in Caenorhabditis elegans

1998 • 918 citations

Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons

1998 • 852 citations

Inflammatory Exposure and Historical Changes in Human Life-Spans

2004 • 759 citations

WormBase: a multi-species resource for nematode biology and genomics

2003 • 673 citations

Resurrecting the Ancestral Steroid Receptor: Ancient Origin of Estrogen Signaling

2003 • 672 citations

Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans.

1995 • 643 citations

Long-Lived C. elegans daf-2 Mutants Are Resistant to Bacterial Pathogens

2003 • 589 citations

Mutation rates in mammalian genomes

2002 • 585 citations

Handbook of the Biology of Aging

1986 • 572 citations

Challenging the dogma: the hidden layer of non‐protein‐coding RNAs in complex organisms

2003 • 567 citations

Multigene Analyses of Bilaterian Animals Corroborate the Monophyly of Ecdysozoa, Lophotrochozoa, and Protostomia

2005 • 550 citations

Demography of Dietary Restriction and Death in Drosophila

2003 • 531 citations

Selection for short introns in highly expressed genes

2002 • 508 citations

Deletion, But Not Antagonism, of the Mouse Growth Hormone Receptor Results in Severely Decreased Body Weights, Insulin, and Insulin-Like Growth Factor I Levels and Increased Life Span

2003 • 504 citations

Mechanisms of aging: public or private?

2002 • 500 citations

Effect of extrinsic mortality on the evolution of senescence in guppies

2004 • 462 citations

The chronological life span of Saccharomyces cerevisiae

2003 • 455 citations

Life history, ecology and longevity in bats

2002 • 410 citations

Longevity, senescence, and the genome

1992 • 409 citations

Gene Loss, Protein Sequence Divergence, Gene Dispensability, Expression Level, and Interactivity Are Correlated in Eukaryotic Evolution

2003 • 401 citations

Shared Transcriptional Signature in Caenorhabditis elegans Dauer Larvae and Long-lived daf-2 Mutants Implicates Detoxification System in Longevity Assurance

2004 • 389 citations

High mutation rate and predominance of insertions in the Caenorhabditis elegans nuclear genome

2004 • 351 citations

EST Analysis of the Cnidarian Acropora millepora Reveals Extensive Gene Loss and Rapid Sequence Divergence in the Model Invertebrates

2003 • 349 citations

The last common bilaterian ancestor

2002 • 320 citations

The Inflammation Hypothesis of Aging

2001 • 307 citations

Dietary Restriction in Long-Lived Dwarf Flies

2002 • 292 citations

Testing the New Animal Phylogeny: First Use of Combined Large-Subunit and Small-Subunit rRNA Gene Sequences to Classify the Protostomes

2002 • 249 citations

Genotype and age influence the effect of caloric intake on mortality in mice

2003 • 231 citations

The Bcl-2-regulated apoptotic pathway

2003 • 222 citations

Heart development inDrosophila and vertebrates: Conservation of molecular mechanisms

1998 • 185 citations

Protein networks, pleiotropy and the evolution of senescence

2004 • 178 citations

The Opisthokonta and the Ecdysozoa May Not Be Clades: Stronger Support for the Grouping of Plant and Animal than for Animal and Fungi and Stronger Support for the Coelomata than Ecdysozoa

2005 • 176 citations

Negligible Senescence during Reproductive Dormancy inDrosophila melanogaster

2001 • 158 citations

Hibernation and Longevity in the Turkish Hamster Mesocricetus brandti

1981 • 154 citations

Principles of Animal Use for Gerontological Research

2000 • 147 citations

Emerging relationships of inflammation, cardiovascular disease and chronic diseases of aging

2003 • 142 citations

Testing an ‘aging gene’ in long‐lived Drosophila strains: increased longevity depends on sex and genetic background

2003 • 140 citations

Effect of Ethoxyquin on the Longevity of C3H Mice

1971 • 129 citations

Defining Wild-Type Life Span in Caenorhabditis elegans

2000 • 129 citations

Molecular mechanisms of yeast aging

1998 • 117 citations

Phylogenetic relationships of the Fox (Forkhead) gene family in the Bilateria

2003 • 116 citations

The longevity ofCaenorhabditis elegansin soil

2005 • 113 citations

Life history response of Mediterranean fruit flies to dietary restriction

2002 • 113 citations

Fins, limbs, and tails: outgrowths and axial patterning in vertebrate evolution

1998 • 112 citations

Systematic searches for molecular synapomorphies in model metazoan genomes give some support for Ecdysozoa after accounting for the idiosyncrasies of Caenorhabditis elegans

2004 • 105 citations

Absence of strong heterosis for life span and other life history traits in Caenorhabditis elegans.

1993 • 104 citations

Cultural artifacts: a comparison of senescence in natural, laboratory-adapted and artificially selected lines of Drosophila melanogaster

2001 • 93 citations

Heads or Tails? Amphioxus and the Evolution of Anterior–Posterior Patterning in Deuterostomes

2002 • 88 citations

Advantages and disadvantages of Caenorhabditis elegans for aging research

2003 • 79 citations

Variable cell number in nematodes

1999 • 75 citations

Dietary Restriction and Aging: Comparative Tests of Evolutionary Hypotheses

2001 • 69 citations

Longevity and ageing in parasitic and free-living nematodes.

2000 • 67 citations

OrthoDisease: A database of human disease orthologs

2004 • 65 citations

The Response to Calorie Restriction in Mammals Shows Features Also Common to Hibernation: A Cross-Adaptation Hypothesis

1997 • 65 citations

Genome-wide RNAi screens in Caenorhabditis elegans: impact on cancer research

2004 • 65 citations

Bilaterian Phylogeny Based on Analyses of a Region of the Sodium–Potassium ATPase β-Subunit Gene

2004 • 64 citations

Axial patterning of C. elegans male sensilla identities by selector genes

2004 • 55 citations

Handbook of the biology of aging, 4th ed.

1996 • 46 citations

Metazoan Evolution: Some Animals Are More Equal than Others

2004 • 45 citations

Laboratory Adaptation of Life History in Drosophila

2001 • 42 citations

Of flies and men; p53, a tumour suppressor

2004 • 42 citations

Evolutionary patterns among measures of aging

1996 • 41 citations

The Proinflammatory Phenotype of Senescent Cells: The p53‐Mediated ICAM‐1 Expression

2004 • 39 citations

Caenorhabditis elegans—a paradigm for aging research: advantages and limitations

2002 • 37 citations

Paralogy and Orthology of Tyrosine Kinases that Can Extend the Life Span of Caenorhabditis elegans

2000 • 33 citations

Dietary Restriction Alone and in Combination With Oral Ethoxyquin/2-Muercaptoethylamine in Mice

1990 • 32 citations

Deleted Work

1955 • 0 citations