Conjugation and deconjugation of ubiquitin regulating the destiny of proteins

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1997 • 71,835 citations

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1994 • 2,480 citations

Themes and variations on ubiquitylation

2001 • 1,475 citations

The ubiquitin-proteasome pathway: on protein death and cell life

1998 • 1,401 citations

Proteasome inhibitors: from research tools to drug candidates

2001 • 1,159 citations

A Novel Ubiquitination Factor, E4, Is Involved in Multiubiquitin Chain Assembly

1999 • 1,031 citations

Ubiquitin-mediated proteolysis: biological regulation via destruction

2000 • 839 citations

Parkin ubiquitinates the α-synuclein–interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

2001 • 738 citations

Potent and selective inhibitors of the proteasome: Dipeptidyl boronic acids

1998 • 674 citations

Multiple Associated Proteins Regulate Proteasome Structure and Function

2002 • 633 citations

Crystal Structure of a UBP-Family Deubiquitinating Enzyme in Isolation and in Complex with Ubiquitin Aldehyde

2002 • 599 citations

Regulation of ubiquitin‐dependent processes by deubiquitinating enzymes

1997 • 576 citations

Chemistry-Based Functional Proteomics Reveals Novel Members of the Deubiquitinating Enzyme Family

2002 • 565 citations

Ubiquitination and deubiquitination: Targeting of proteins for degradation by the proteasome

2000 • 560 citations

A soluble ATP-dependent proteolytic system responsible for the degradation of abnormal proteins in reticulocytes.

1977 • 553 citations

The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene

1993 • 379 citations

Mechanistic Studies on the Inactivation of the Proteasome by Lactacystin

1996 • 370 citations

Differential Inhibition of Calpain and Proteasome Activities by Peptidyl Aldehydes of Di-Leucine and Tri-Leucine

1996 • 288 citations

Structural basis for the specificity of ubiquitin C-terminal hydrolases

1999 • 279 citations

Protein Degradation or Regulation: Ub the Judge

1996 • 275 citations

Deubiquitinating Enzymes: A New Class of Biological Regulators

1998 • 266 citations

Control of Cell Fate by a Deubiquitinating Enzyme Encoded by the fat facets Gene

1995 • 262 citations

A Deubiquitinating Enzyme Interacts with SIR4 and Regulates Silencing in S. cerevisiae

1996 • 228 citations

Analysis of the Deubiquitinating Enzymes of the Yeast Saccharomyces cerevisiae

2000 • 188 citations

Total Synthesis and Biological Activity of Lactacystin, Omuralide and Analogs.

1999 • 185 citations

cDNA Cloning and Interferon γ Down-Regulation of Proteasomal Aubunits X and Y

1994 • 181 citations

The function of the Drosophila fat facets deubiquitinating enzyme in limiting photoreceptor cell number is intimately associated with endocytosis

2000 • 176 citations

DUB-1, a deubiquitinating enzyme with growth-suppressing activity.

1996 • 170 citations

Direct interactions of the five known Fanconi anaemia proteins suggest a common functional pathway

2001 • 168 citations

The Regulatory Complex of Drosophila melanogaster 26s Proteasomes

2000 • 145 citations

DUB-2 Is a Member of a Novel Family of Cytokine-inducible Deubiquitinating Enzymes

1997 • 111 citations

Role of the proteasome in Alzheimer’s disease

2000 • 95 citations

Elevated expression of Unph, a proto-oncogene at 3p21.3, in human lung tumors

1995 • 92 citations

Carbon catabolite repression in Aspergillus nidulans involves deubiquitination

2001 • 88 citations

Lessons from the discovery ofthe ubiquitin system

1996 • 84 citations

The Fanconi anemia protein, FANCE, promotes the nuclear accumulation of FANCC

2002 • 82 citations

The ubiquitin protein catabolic disorders

2001 • 80 citations

Regulation of the Fanconi anemia pathway by monoubiquitination

2002 • 75 citations

FAM deubiquitylating enzyme is essential for preimplantation mouse embryo development

2001 • 59 citations

Antagonistic regulation of myogenesis by two deubiquitinating enzymes, UBP45 and UBP69

2002 • 51 citations

DUB-2A, a new member of the DUB subfamily of hematopoietic deubiquitinating enzymes

2001 • 46 citations

The Chinese hamster FANCG/XRCC9 mutant NM3 fails to express the monoubiquitinated form of the FANCD2 protein, is hypersensitive to a range of DNA damaging agents and exhibits a normal level of spontaneous sister chromatid exchange

2001 • 46 citations

Molecular Cloning of a Novel Ubiquitin-specific Protease, UBP41, with Isopeptidase Activity in Chick Skeletal Muscle

1997 • 45 citations

Glutamate Residues Required for Substrate Binding and Cleavage Activity in Mitochondrial Processing Peptidase

1998 • 29 citations

Soluble factor from tumor cells induces heme oxygenase-1 by a nitric oxide-independent mechanism in murine peritoneal macrophages

2003 • 11 citations

Critical regions for deubiquitinating activity of DUB‐2 expressed in T‐lymphocytes

2001 • 6 citations

Molecular Cloning and Complete cDNA Sequence of UBH1 in Mouse Testis

2002 • 5 citations