Regulation of NMDA receptor subunit expression and its implications for LTD, LTP, and metaplasticity

Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path

1973 • 7,118 citations

Magnesium gates glutamate-activated channels in mouse central neurones

1984 • 3,999 citations

LTP and LTD

2004 • 3,754 citations

Developmental and regional expression in the rat brain and functional properties of four NMDA receptors

1994 • 3,437 citations

Theory for the development of neuron selectivity: orientation specificity and binocular interaction in visual cortex

1982 • 2,824 citations

Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones

1984 • 2,822 citations

SINGLE-CELL RESPONSES IN STRIATE CORTEX OF KITTENS DEPRIVED OF VISION IN ONE EYE

1963 • 2,565 citations

Structural basis of long-term potentiation in single dendritic spines

2004 • 2,331 citations

The molecular basis of CaMKII function in synaptic and behavioural memory

2002 • 1,855 citations

Genetic enhancement of learning and memory in mice

1999 • 1,831 citations

NMDA receptor subunits: diversity, development and disease

2001 • 1,677 citations

Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade.

1992 • 1,675 citations

Metaplasticity: the plasticity of synaptic plasticity

1996 • 1,638 citations

Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

2002 • 1,612 citations

Changing subunit composition of heteromeric NMDA receptors during development of rat cortex

1994 • 1,342 citations

Recombinant BDNF Rescues Deficits in Basal Synaptic Transmission and Hippocampal LTP in BDNF Knockout Mice

1996 • 1,219 citations

Intracellular injections of EGTA block induction of hippocampal long-term potentiation

1983 • 1,106 citations

NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders

2007 • 1,089 citations

Role of NMDA Receptor Subtypes in Governing the Direction of Hippocampal Synaptic Plasticity

2004 • 1,084 citations

Shrinkage of Dendritic Spines Associated with Long-Term Depression of Hippocampal Synapses

2004 • 989 citations

Metaplasticity: tuning synapses and networks for plasticity

2008 • 974 citations

Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system

2003 • 972 citations

Nitric oxide as modulator of neuronal function

2001 • 937 citations

Activation of Synaptic NMDA Receptors Induces Membrane Insertion of New AMPA Receptors and LTP in Cultured Hippocampal Neurons

2001 • 898 citations

Experience-Dependent Plasticity of Binocular Responses in the Primary Visual Cortex of the Mouse

1996 • 833 citations

Signal-Processing Machines at the Postsynaptic Density

2000 • 792 citations

The Incorporation of NMDA Receptors with a Distinct Subunit Composition at Nascent Hippocampal SynapsesIn Vitro

1999 • 780 citations

Role of Distinct NMDA Receptor Subtypes at Central Synapses

2004 • 766 citations

Ras and Rap Control AMPA Receptor Trafficking during Synaptic Plasticity

2002 • 756 citations

Activity-Dependent Decrease in NMDA Receptor Responses During Development of the Visual Cortex

1992 • 731 citations

Interaction with the NMDA receptor locks CaMKII in an active conformation

2001 • 695 citations

NMDA Receptor Subunit Composition Controls Synaptic Plasticity by Regulating Binding to CaMKII

2005 • 685 citations

Differential Roles of NR2A and NR2B-Containing NMDA Receptors in Cortical Long-Term Potentiation and Long-Term Depression

2004 • 678 citations

Functional and Pharmacological Differences Between RecombinantN-Methyl-<scp>d</scp>-Aspartate Receptors

1998 • 662 citations

Regional distribution of type II Ca2+/calmodulin-dependent protein kinase in rat brain

1985 • 625 citations

SynGAP: a Synaptic RasGAP that Associates with the PSD-95/SAP90 Protein Family

1998 • 617 citations

Experience-dependent modification of synaptic plasticity in visual cortex

1996 • 617 citations

NR2A Subunit Expression Shortens NMDA Receptor Synaptic Currents in Developing Neocortex

1997 • 612 citations

A unified model of NMDA receptor-dependent bidirectional synaptic plasticity

2002 • 605 citations

Experience and Activity-Dependent Maturation of Perisomatic GABAergic Innervation in Primary Visual Cortex during a Postnatal Critical Period

2004 • 592 citations

Rapid, experience-dependent expression of synaptic NMDA receptors in visual cortex in vivo

1999 • 579 citations

The Origin and Neuronal Function ofIn VivoNonsynaptic Glutamate

2002 • 571 citations

Hebbian synapses in hippocampus.

1986 • 560 citations

Molecular determinants of NMDA receptor internalization

2001 • 529 citations

Developmental regulation of NMDA receptor-mediated synaptic currents at a central synapse

1992 • 529 citations

A Developmental Change in NMDA Receptor-Associated Proteins at Hippocampal Synapses

2000 • 521 citations

Selective Induction of LTP and LTD by Postsynaptic [Ca²⁺]_i Elevation

1999 • 512 citations

Subunit-Specific NMDA Receptor Trafficking to Synapses

2002 • 503 citations

Activity Regulates the Synaptic Localization of the NMDA Receptor in Hippocampal Neurons

1997 • 493 citations

Emotion Enhances Learning via Norepinephrine Regulation of AMPA-Receptor Trafficking

2007 • 488 citations

Regulation of NMDA channel function by endogenous Ca2+-dependent phosphatase

1994 • 483 citations

Roles of NMDA NR2B Subtype Receptor in Prefrontal Long-Term Potentiation and Contextual Fear Memory

2005 • 482 citations

Semiquantitative Proteomic Analysis of Rat Forebrain Postsynaptic Density Fractions by Mass Spectrometry

2004 • 475 citations

Autophosphorylation-dependent Targeting of Calcium/ Calmodulin-dependent Protein Kinase II by the NR2B Subunit of theN-Methyl-d-aspartate Receptor

1998 • 442 citations

Tonic Activation of NMDA Receptors by Ambient Glutamate Enhances Excitability of Neurons

1989 • 434 citations

In vivo determination of extracellular concentration of amino acids in the rat hippocampus. A method based on brain dialysis and computerized analysis

1986 • 428 citations

The NMDA Receptor Is Coupled to the ERK Pathway by a Direct Interaction between NR2B and RasGRF1

2003 • 427 citations

Hebbian synapses in visual cortex

1994 • 416 citations

Subunit‐specific gating controls rat NR1/NR2A and NR1/NR2B NMDA channel kinetics and synaptic signalling profiles

2005 • 415 citations

An NMDA Receptor ER Retention Signal Regulated by Phosphorylation and Alternative Splicing

2001 • 414 citations

Mobile NMDA Receptors at Hippocampal Synapses

2002 • 413 citations

Visual Experience and Deprivation Bidirectionally Modify the Composition and Function of NMDA Receptors in Visual Cortex

2001 • 411 citations

Regional and developmental heterogeneity in splicing of the rat brain NMDAR1 mRNA

1994 • 405 citations

Neuromodulators Control the Polarity of Spike-Timing-Dependent Synaptic Plasticity

2007 • 405 citations

Synaptic Desensitization of NMDA Receptors by Calcineurin

1995 • 404 citations

How Monocular Deprivation Shifts Ocular Dominance in Visual Cortex of Young Mice

2004 • 404 citations

Differential activity-dependent regulation of the lateral mobilities of AMPA and NMDA receptors

2004 • 403 citations

α-CaMKII-dependent plasticity in the cortex is required for permanent memory

2001 • 399 citations

Calcium/calmodulin-dependent protein kinase II is associated with the N -methyl- <scp>d</scp> -aspartate receptor

1999 • 377 citations

Bidirectional, experience-dependent regulation of N- methyl- <scp>d</scp> -aspartate receptor subunit composition in the rat visual cortex during postnatal development

1999 • 377 citations

Increased contribution of NR2A subunit to synaptic NMDA receptors in developing rat cortical neurons

1998 • 364 citations

The Synaptic Localization of NR2B-Containing NMDA Receptors Is Controlled by Interactions with PDZ Proteins and AP-2

2005 • 364 citations

PDZ Domain Suppression of an ER Retention Signal in NMDA Receptor NR1 Splice Variants

2000 • 344 citations

Activity Coregulates Quantal AMPA and NMDA Currents at Neocortical Synapses

2000 • 344 citations

NMDA receptor surface mobility depends on NR2A-2B subunits

2006 • 343 citations

Homeostatic Regulation of Eye-Specific Responses in Visual Cortex during Ocular Dominance Plasticity

2007 • 334 citations

Can molecules explain long-term potentiation?

1999 • 333 citations

Rapid Bidirectional Switching of Synaptic NMDA Receptors

2007 • 332 citations

Mechanism and Regulation of Calcium/Calmodulin-dependent Protein Kinase II Targeting to the NR2B Subunit of the N-Methyl-d-aspartate Receptor

2000 • 332 citations

Dark Rearing Alters the Development of GABAergic Transmission in Visual Cortex

2002 • 324 citations

A developmental switch in the signaling cascades for LTP induction

2002 • 322 citations

Extracellular Glutamate Concentration in Hippocampal Slice

2007 • 321 citations

The contribution of sensory experience to the maturation of orientation selectivity in ferret visual cortex

2001 • 314 citations

Molecular mechanism for loss of visual cortical responsiveness following brief monocular deprivation

2003 • 313 citations

Switching of NMDA Receptor 2A and 2B Subunits at Thalamic and Cortical Synapses during Early Postnatal Development

2004 • 309 citations

Instructive Effect of Visual Experience in Mouse Visual Cortex

2006 • 307 citations

Opposing role of synaptic and extrasynaptic NMDA receptors in regulation of the extracellular signal‐regulated kinases (ERK) activity in cultured rat hippocampal neurons

2006 • 304 citations

Lack of NMDA Receptor Subtype Selectivity for Hippocampal Long-Term Potentiation

2005 • 301 citations

Integration of biochemical signalling in spines

2005 • 283 citations

NMDA Receptor Subunit-Dependent [Ca²+] Signaling in Individual Hippocampal Dendritic Spines

2005 • 277 citations

Synaptic and Extrasynaptic NMDA Receptor NR2 Subunits in Cultured Hippocampal Neurons

2005 • 274 citations

Visual Deprivation Reactivates Rapid Ocular Dominance Plasticity in Adult Visual Cortex

2006 • 270 citations

Bidirectional synaptic plasticity: from theory to reality

2003 • 263 citations

Subtype-Dependence of NMDA Receptor Channel Open Probability

1999 • 259 citations

Influence of experience on orientation maps in cat visual cortex

1999 • 255 citations

Relating NMDA Receptor Function to Receptor Subunit Composition: Limitations of the Pharmacological Approach

2006 • 241 citations

Activity-Dependent mRNA Splicing Controls ER Export and Synaptic Delivery of NMDA Receptors

2003 • 240 citations

Subunit-Specific Regulation of NMDA Receptor Endocytosis

2004 • 239 citations

Modulation of Triheteromeric NMDA Receptors by N-Terminal Domain Ligands

2005 • 231 citations

A novel mechanism of activity‐dependent NMDA receptor antagonism describes the effect of ifenprodil in rat cultured cortical neurones.

1996 • 230 citations

NMDA Di-Heteromeric Receptor Populations and Associated Proteins in Rat Hippocampus

2007 • 226 citations

The effect of dark rearing on the time course of the critical period in cat visual cortex

1991 • 225 citations

Activation of NR2B-containing NMDA receptors is not required for NMDA receptor-dependent long-term depression

2006 • 224 citations

Gene expression changes and molecular pathways mediating activity-dependent plasticity in visual cortex

2006 • 224 citations

Synaptic plasticity at thalamocortical synapses in developing rat somatosensory cortex: LTP, LTD, and silent synapses

1999 • 220 citations

Regulation of Synaptic Strength by Protein Phosphatase 1

2001 • 220 citations

Asymmetrical Allocation of NMDA Receptor ε2 Subunits in Hippocampal Circuitry

2003 • 211 citations

NMDA Receptor Surface Trafficking and Synaptic Subunit Composition Are Developmentally Regulated by the Extracellular Matrix Protein Reelin

2007 • 211 citations

NR2B-Containing Receptors Mediate Cross Talk among Hippocampal Synapses

2004 • 197 citations

Obligatory Role of NR2A for Metaplasticity in Visual Cortex

2007 • 196 citations

Evidence for Altered NMDA Receptor Function as a Basis for Metaplasticity in Visual Cortex

2003 • 194 citations

Insufficient Sleep Reversibly Alters Bidirectional Synaptic Plasticity and NMDA Receptor Function

2006 • 187 citations

Postsynaptic Density Protein-95 Regulates NMDA Channel Gating and Surface Expression

2004 • 185 citations

Distinct triggering and expression mechanisms underlie LTD of AMPA and NMDA synaptic responses

2005 • 183 citations

Barrel Cortex Critical Period Plasticity Is Independent of Changes in NMDA Receptor Subunit Composition

2001 • 182 citations

NMDAR EPSC kinetics do not regulate the critical period for LTP at thalamocortical synapses

2001 • 181 citations

Separable features of visual cortical plasticity revealed by N -methyl- <scp>d</scp> -aspartate receptor 2A signaling

2003 • 180 citations

Extrasynaptic and synaptic NMDA receptors form stable and uniform pools in rat hippocampal slices

2007 • 179 citations

Interactions between the NR2B Receptor and CaMKII Modulate Synaptic Plasticity and Spatial Learning

2007 • 176 citations

Activation of NR2A-Containing NMDA Receptors Is Not Obligatory for NMDA Receptor-Dependent Long-Term Potentiation

2005 • 170 citations

A biophysical model of bidirectional synaptic plasticity: Dependence on AMPA and NMDA receptors

2001 • 167 citations

Extrasynaptic NR2B and NR2D subunits of NMDA receptors shape ‘superslow’ afterburst EPSC in rat hippocampus

2004 • 162 citations

A Molecular Mechanism for Stabilization of Learning-Induced Synaptic Modifications

2004 • 157 citations

Enhanced NR2A Subunit Expression and Decreased NMDA Receptor Decay Time at the Onset of Ocular Dominance Plasticity in the Ferret

1999 • 153 citations

Relationship between Availability of NMDA Receptor Subunits and Their Expression at the Synapse

2002 • 148 citations

Pathway-Specific Differences in Subunit Composition of Synaptic NMDA Receptors on Pyramidal Neurons in Neocortex

2003 • 142 citations

Structure–activity analysis of a novel NR2C/NR2D‐preferring NMDA receptor antagonist: 1‐(phenanthrene‐2‐carbonyl) piperazine‐2,3‐dicarboxylic acid

2004 • 142 citations

cAMP-Dependent Protein Kinase Mediates Activity-Regulated Synaptic Targeting of NMDA Receptors

2001 • 140 citations

Synaptic Activity Modulates the Induction of Bidirectional Synaptic Changes in Adult Mouse Hippocampus

2000 • 138 citations

Postsynaptic control of hippocampal long-term potentiation.

1986 • 135 citations

Optimization of Somatic Inhibition at Critical Period Onset in Mouse Visual Cortex

2007 • 131 citations

Inhibitory Control of LTP and LTD: Stability of Synapse Strength

1999 • 127 citations

Autophosphorylation of αCaMKII Is Required for Ocular Dominance Plasticity

2002 • 123 citations

Two Forms of Synaptic Plasticity with Distinct Dependence on Age, Experience, and NMDA Receptor Subtype in Rat Visual Cortex

2003 • 122 citations

Endocytosis and Degradative Sorting of NMDA Receptors by Conserved Membrane-Proximal Signals

2004 • 118 citations

Decline of the Critical Period of Visual Plasticity Is Concurrent with the Reduction of NR2B Subunit of the Synaptic NMDA Receptor in Layer 4

2003 • 116 citations

Age-dependent decrease of synaptic plasticity in the neocortex of αCaMKII mutant mice

1997 • 114 citations

Maturation of GABAergic transmission and the timing of plasticity in visual cortex

2005 • 112 citations

Developmental loss of miniature N -methyl- <scp>d</scp> -aspartate receptor currents in NR2A knockout mice

2003 • 110 citations

Nicotine Regulates Multiple Synaptic Proteins by Inhibiting Proteasomal Activity

2007 • 110 citations

αCaMKII binding to the C‐terminal tail of NMDA receptor subunit NR2A and its modulation by autophosphorylation

1999 • 110 citations

Sequential Development of Long-Term Potentiation and Depression in Different Layers of the Mouse Visual Cortex

2007 • 109 citations

Developmental Down-Regulation of LTD in Cortical Layer IV and Its Independence of Modulation by Inhibition

1996 • 108 citations

Activity-dependent regulation of NR2B translation contributes to metaplasticity in mouse visual cortex

2006 • 107 citations

NMDA receptor upregulation: molecular studies in cultured mouse cortical neurons after chronic antagonist exposure

1996 • 106 citations

Aging is associated with elevated intracellular calcium levels and altered calcium homeostatic mechanisms in hippocampal neurons

2007 • 104 citations

Synaptic Activity‐Dependent Developmental Regulation of NMDA Receptor Subunit Expression in Cultured Neocortical Neurons

2000 • 104 citations

Exon 5 and Spermine Regulate Deactivation of NMDA Receptor Subtypes

2000 • 103 citations

Activity-Dependent Plasticity of the NMDA-Receptor Fractional Ca2+ Current

2007 • 102 citations

Activation of NMDA Receptors in Rat Dentate Gyrus Granule Cells by Spontaneous and Evoked Transmitter Release

2003 • 97 citations

Ifenprodil and Ethanol Enhance NMDA Receptor-Dependent Long-Term Depression

2002 • 93 citations

Genetic and epigenetic regulation of NMDA receptor expression in the rat visual cortex

1999 • 92 citations

Developmental changes in the expression of NMDA receptor subunits (NR1, NR2A, NR2B) in the cat visual cortex and the effects of dark rearing

2000 • 90 citations

Absence of Long-Term Depression in the Visual Cortex of Glutamic Acid Decarboxylase-65 Knock-Out Mice

2002 • 84 citations

Export from the Endoplasmic Reticulum of Assembled N-Methyl-D-aspartic Acid Receptors Is Controlled by a Motif in the C Terminus of the NR2 Subunit

2004 • 84 citations

Extracellular Level of GABA and Glu: In Vivo Microdialysis-HPLC Measurements

2006 • 83 citations

Subunit Assembly of N-Methyl-d-aspartate Receptors Analyzed by Fluorescence Resonance Energy Transfer

2005 • 80 citations

Long‐term potentiation inhibition by low‐level N‐methyl‐<scp>D</scp>‐aspartate receptor activation involves calcineurin, nitric oxide, and p38 mitogen‐activated protein kinase

2007 • 76 citations

Visual Deprivation Modifies Both Presynaptic Glutamate Release and the Composition of Perisynaptic/Extrasynaptic NMDA Receptors in Adult Visual Cortex

2005 • 75 citations

Mind Bomb-2 Is an E3 Ligase That Ubiquitinates the N-Methyl-d-aspartate Receptor NR2B Subunit in a Phosphorylation-dependent Manner

2007 • 74 citations

Recruiting Extrasynaptic NMDA Receptors Augments Synaptic Signaling

2007 • 70 citations

NMDA Currents and Receptor Protein Are Downregulated in the Amygdala during Maintenance of Fear Memory

2003 • 68 citations

Experience-dependent changes in NMDA receptor composition at mature central synapses

2007 • 68 citations

Long-Term Potentiation in the Visual Cortex Requires Both Nitric Oxide Receptor Guanylyl Cyclases

2007 • 68 citations

Critical period control in sensory cortex

1994 • 67 citations

Dissociation of experience-dependent and -independent changes in excitatory synaptic transmission during development of barrel cortex

2004 • 66 citations

NR2A^−/−Mice Lack Long-Term Potentiation But Retain NMDA Receptor and L-Type Ca²⁺Channel-Dependent Long-Term Depression in the Juvenile Superior Colliculus

2007 • 52 citations

Sequence determinants on the NR2A and NR2B subunits of NMDA receptor responsible for specificity of phosphorylation by CaMKII

2002 • 52 citations

NMDA-Dependent, But Not Group I Metabotropic Glutamate Receptor-Dependent, Long-Term Depression at Schaffer Collateral–CA1 Synapses Is Associated with Long-Term Reduction of Release from the Rapidly Recycling Presynaptic Vesicle Pool

2006 • 42 citations

Developmental regulation of subunit composition of extrasynaptic NMDA receptors in neocortical neurones

2000 • 32 citations

Analysis of Transcriptional Regulatory Sequences of the N-Methyl-d-aspartate Receptor 2A Subunit Gene in Cultured Cortical Neurons and Transgenic Mice

2002 • 25 citations

Developmental differences in alternative splicing of the NR1 protein in rat cortex and cerebellum

2000 • 25 citations

Dark-rearing decreases NR2A N-methyl-d-aspartate receptor subunit in all visual cortical layers

2003 • 21 citations