The role of glutathione in resistance to cisplatin in a human small cell lung cancer cell line

Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues

1969 • 6,007 citations

Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing.

1987 • 3,809 citations

Augmentation of adriamycin, melphalan, and cisplatin cytotoxicity in drug-resistant and -sensitive human ovarian carcinoma cell lines by buthionine sulfoximine mediated glutathione depletion

1985 • 545 citations

Glutathione metabolism as a determinant of therapeutic efficacy: a review.

1984 • 505 citations

Characterization of a cis-diamminedichloroplatinum(II)-resistant human ovarian cancer cell line and its use in evaluation of platinum analogues.

1987 • 498 citations

Short-termcis-diamminedichloroplatinum(II) accumulation in sensitive and resistant human ovarian carcinoma cells

1990 • 357 citations

Enhanced DNA repair as a mechanism of resistance to cis-diamminedichloroplatinum(II)

1988 • 314 citations

Characterization of a human squamous carcinoma cell line resistant to cis-diamminedichloroplatinum(II).

1987 • 288 citations

cis-Diamminedichloroplatinum(II)-induced DNA adducts in peripheral leukocytes from seven cancer patients: quantitative immunochemical detection of the adduct induction and removal after a single dose of cis-diamminedichloroplatinum(II).

1987 • 266 citations

Potentiation of melphalan cytotoxicity in human ovarian cancer cell lines by glutathione depletion.

1984 • 235 citations

Multiple mechanisms of resistance to cis-diamminedichloroplatinum(II) in murine leukemia L1210 cells.

1987 • 232 citations

Effect of Glutathione on DNA Repair in Cisplatin-Resistant Human Ovarian Cancer Cell Lines

1989 • 168 citations

Cross-linking of glutathione to DNA by cancer chemotherapeutic platinum coordination complexes

1987 • 140 citations

Differential repair of platinum-DNA adducts in human bladder and testicular tumor continuous cell lines.

1988 • 131 citations

Characterization of a human small cell lung carcinoma cell line with acquired resistance to cis-diamminedichloroplatinum(II) in vitro

1989 • 130 citations

Accumulation of cis-diamminedichloroplatinum(II) and platinum analogues by platinum-resistant murine leukemia cells in vitro.

1988 • 119 citations

Glutathione depletion as a determinant of sensitivity of human leukemia cells to cyclophosphamide.

1986 • 105 citations

Differential uptake of cis-diamminedichloroplatinum (II) by sensitive and resistant murine L1210 leukemia cells.

1987 • 102 citations

Quenching of DNA:platinum(II) monoadducts as a possible mechanism of resistance to cis-diamminedichloroplatinum(II) in L1210 cells.

1983 • 96 citations

Glutathione and related enzymes in rat brain tumor cell resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea and nitrogen mustard.

1987 • 94 citations

Immunochemical quantitation of adducts induced in DNA by cis-diamminedichloroplatinum(II) and analysis of adduct-related DNA-unwinding

1985 • 75 citations

Elevated DNA topoisomerase II activity in nitrogen mustard-resistant human cells.

1987 • 75 citations

Glutathione depletion reverses cisplatin resistance in murine L1210 leukemia cells☆

1987 • 73 citations

Effect of D,L-buthionine-S,R-sulfoximine on cytotoxicity and DNA cross-linking induced by bifunctional DNA-reactive cytostatic drugs in human melanoma cells.

1988 • 43 citations

Effects of dimethyl sulfoxide and thiourea upon intercalator-induced DNA single-strand breaks in mouse leukemia (L1210) cells.

1983 • 41 citations

Compartmentalised depletion of glutathione in cells treated with buthionine sulphoximine

1987 • 41 citations

Detection of DNA cross‐links in tumor cells with the ethidium bromide fluorescence assay

1986 • 32 citations

REPAIR OF cis-PLATINUM (II) DIAMMINE DICHLORIDE-INDUCED DNA DAMAGE AND CELL SENSITIVITY

1980 • 20 citations

The formation and removal of cisplatin (CDDP) induced DNA adducts in a CDDP sensitive and resistant human small cell lung carcinoma (HSCLC) cell line

1990 • 18 citations

The formation and removal of cisplatin (CDDP) induced DNA adducts in a CDDP sensitive and resistant human small cell lung carcinoma (HSCLC) cell line

1990 • 1 citations

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