Treadmill training ameliorates dopamine loss but not behavioral deficits in hemi-Parkinsonian rats

The Rat Brain in Stereotaxic Coordinates

1982 • 53,055 citations

Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system

1970 • 1,980 citations

Postsynaptic Supersensitivity after 6‐Hydroxy‐dopamine Induced Degeneration of the Nigro‐striatal Dopamine System

1971 • 1,922 citations

CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury

2000 • 1,288 citations

Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model

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Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: A combined retrograde tracing and immunocytochemical study in the rat

1994 • 786 citations

Cortical and subcortical lesions impair skilled walking in the ladder rung walking test: a new task to evaluate fore- and hindlimb stepping, placing, and co-ordination

2002 • 652 citations

Proteasomal function is impaired in substantia nigra in Parkinson's disease

2001 • 631 citations

Forelimb akinesia in the rat Parkinson model: differential effects of dopamine agonists and nigral transplants as assessed by a new stepping test

1995 • 613 citations

Prospects for new restorative and neuroprotective treatments in Parkinson's disease

1999 • 545 citations

Failure of the ubiquitin–proteasome system in Parkinson's disease

2001 • 508 citations

Exercise induces behavioral recovery and attenuates neurochemical deficits in rodent models of Parkinson's disease

2003 • 401 citations

Dopamine transporters and neuronal injury

1999 • 376 citations

Correlation of apomorphine- and amphetamine-induced turning with nigrostriatal dopamine content in unilateral 6-hydroxydopamine lesioned rats

1993 • 371 citations

Mechanism of 6-hydroxydopamine neurotoxicity

1997 • 364 citations

Forced Limb-Use Effects on the Behavioral and Neurochemical Effects of 6-Hydroxydopamine

2001 • 355 citations

Exercise‐induced behavioral recovery and neuroplasticity in the 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine‐lesioned mouse basal ganglia

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Regulation of brain function by exercise

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Short-Term GDNF Treatment Provides Long-Term Rescue of Lesioned Nigral Dopaminergic Neurons in a Rat Model of Parkinson’s Disease

1996 • 258 citations

Neuroprotective effects of prior limb use in 6‐hydroxydopamine‐treated rats: possible role of GDNF

2003 • 246 citations

Biochemical and anatomical characterization of forepaw adjusting steps in rat models of Parkinson's disease: studies on medial forebrain bundle and striatal lesions

1999 • 240 citations

Environmental enrichment in adulthood eliminates neuronal death in experimental Parkinsonism

2004 • 236 citations

Striatal dopamine turnover during treadmill running in the rat: Relation to the speed of running

1994 • 222 citations

From entropy to Duino

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Forced Nonuse in Unilateral Parkinsonian Rats Exacerbates Injury

2002 • 163 citations

Red nucleus lesions impair overground locomotion in rats: a kinetic analysis

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Skilled reaching deficits in unilateral dopamine-depleted rats: impairments in movement and posture and compensatory adjustments

1994 • 126 citations

Intranigral Transplants of GABA-Rich Striatal Tissue Induce Behavioral Recovery in the Rat Parkinson Model and Promote the Effects Obtained by Intrastriatal Dopaminergic Transplants

1999 • 117 citations

Compensatory Locomotor Adjustments of Rats with Cervical or Thoracic Spinal Cord Hemisections

2002 • 97 citations

Stress‐Induced Dopamine Release in the Neostriatum: Evaluation of the Role of Action Potentials in Nigrostriatal Dopamine Neurons or Local Initiation by Endogenous Excitatory Amino Acids

1993 • 96 citations

Drug-induced rotation intensity in unilateral dopamine-depleted rats is not correlated with end point or qualitative measures of forelimb or hindlimb motor performance

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Comparison of unilateral and bilateral intrastriatal 6‐hydroxydopamine‐induced axon terminal lesions: Evidence for interhemispheric functional coupling of the two nigrostriatal pathways

2001 • 92 citations

Voluntary Running Provides Neuroprotection in Rats After 6-Hydroxydopamine Injection into the Medial Forebrain Bundle

2004 • 90 citations

Effects of complete and partial lesions of the dopaminergic mesotelencephalic system on skilled forelimb use in the rat

1995 • 86 citations

Unilateral dorsal column and rubrospinal tract injuries affect overground locomotion in the unrestrained rat

2003 • 84 citations

NAIP protects the nigrostriatal dopamine pathway in an intrastriatal 6‐OHDA rat model of Parkinson's disease

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Motor training effects on recovery of function after striatal lesions and striatal grafts

2003 • 81 citations

Impairments and compensatory adjustments in spontaneous movement after unilateral dopamine depletion in rats

1995 • 79 citations

Ground reaction forces in locomoting hemi-parkinsonian rats: a definitive test for impairments and compensations

1999 • 76 citations

A Novel Skilled-Reaching Impairment in Paw Supination on the “Good” Side of the Hemi-Parkinson Rat Improved with Rehabilitation

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Frequency and Cause of Parkinson’s Disease

1992 • 75 citations

The Potential for Circuit Reconstruction by Expanded Neural Precursor Cells Explored through Porcine Xenografts in a Rat Model of Parkinson's Disease

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Enhancement of Sensorimotor Behavioral Recovery in Hemiparkinsonian Rats with Intrastriatal, Intranigral, and Intrasubthalamic Nucleus Dopaminergic Transplants

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Relationships between various behavioural abnormalities and nigrostriatal dopamine depletion in the unilateral 6-OHDA-lesioned rat

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Paradoxical Kinesia in Parkinsonism Is Not Caused by Dopamine Release

1989 • 62 citations

Environmental stress increases extracellular dopamine in striatum of 6-hydroxydopamine-treated rats: in vivo microdialysis studies

1990 • 60 citations

6-Hydroxydopamine increases ubiquitin-conjugates and protein degradation: implications for the pathogenesis of Parkinson's disease.

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Mechanism and consequences of nerve cell death in Parkinson’s disease

1999 • 37 citations

Brain-dependent movements and cerebral-spinal connections: Key targets of cellular and behavioral enrichment in CNS injury models

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The ground reaction forces of postural adjustments during skilled reaching in unilateral dopamine-depleted hemiparkinson rats

1997 • 31 citations

Sparing of behavior and basal extracellular dopamine after 6-hydroxydopamine lesions of the nigrostriatal pathway in rats exposed to a prelesion sensitizing regimen of amphetamine

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Diazepam potentiates the effect of neuroleptics on behavioural activity as well as dopamine and norepinephrine turnover: Do benzodiazepines have antipsychotic potency?

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Akinesia and postural abnormality after unilateral dopamine depletion

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Protection by BTCP of cultured dopaminergic neurons exposed to neurotoxins

1993 • 24 citations