Islet Amyloid and Type 2 Diabetes Mellitus

Amyloid Deposits and Amyloidosis

1980 • 1,787 citations

Common core structure of amyloid fibrils by synchrotron X-ray diffraction 1 1Edited by F. E. Cohen

1997 • 1,648 citations

Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis

1997 • 1,041 citations

β-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: Implications for Alzheimer's therapy

1998 • 839 citations

Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus

1994 • 815 citations

Efficacy and Metabolic Effects of Metformin and Troglitazone in Type II Diabetes Mellitus

1998 • 798 citations

Islet amyloid polypeptide: pinpointing amino acid residues linked to amyloid fibril formation.

1990 • 782 citations

The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles.

1999 • 600 citations

A novel peptide in the calcitonin gene related peptide family as an amyloid fibril protein in the endocrine pancreas

1986 • 493 citations

Islet amyloid: a long-recognized but underappreciated pathological feature of type 2 diabetes.

1999 • 483 citations

A Seroepidemiologic Survey of the Prevalence of Herpes Simplex Virus Type 2 Infection in the United States

1989 • 463 citations

Pore Formation by the Cytotoxic Islet Amyloid Peptide Amylin

1996 • 439 citations

Disaggregation of Alzheimer β-amyloid by site-directed mAb

1997 • 417 citations

Type 2 Diabetes: When Insulin Secretion Fails to Compensate for Insulin Resistance

1998 • 415 citations

Spontaneous diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide.

1996 • 334 citations

THE RELATION OE DIABETES MELLITUS TO LESIONS OF THE PANCREAS. HYALINE DEGENERATION OF THE ISLANDS OE LANGERHANS

1901 • 298 citations

Pancreatic beta-cell dysfunction as the primary genetic lesion in NIDDM. Evidence from studies in normal glucose-tolerant individuals with a first-degree NIDDM relative

1995 • 289 citations

Amyloid deposition is delayed in mice with targeted deletion of the serum amyloid P component gene

1997 • 257 citations

Effects of Sequential Proline Substitutions on Amyloid Formation by Human Amylin_20-29

1999 • 195 citations

Amyloid P component. A critical review

1997 • 182 citations

AMYLOIDOSIS: A REVIEW OF RECENT DIAGNOSTIC AND THERAPEUTIC DEVELOPMENTS

1997 • 176 citations

The insulin and islet amyloid polypeptide genes contain similar cell-specific promoter elements that bind identical beta-cell nuclear complexes.

1992 • 168 citations

Increased Insulin Secretion and Glucose Tolerance in Mice Lacking Islet Amyloid Polypeptide (Amylin)

1998 • 156 citations

Extensive islet amyloid formation is induced by development of Type II diabetes mellitus and contributes to its progression: pathogenesis of diabetes in a mouse model

1999 • 153 citations

Islet amyloid-associated diabetes in obese A(vy)/a mice expressing human islet amyloid polypeptide.

1998 • 143 citations

Longitudinal studies on the development of diabetes in individual Macaca nigra

1986 • 137 citations

Sulfate content and specific glycosaminoglycan backbone of perlecan are critical for perlecan's enhancement of islet amyloid polypeptide (amylin) fibril formation.

1998 • 132 citations

Islet amyloid polypeptide: Identification and chromosomal localization of the human gene

1988 • 112 citations

Contribution of advanced glycosylation to the amyloidogenicity of islet amyloid polypeptide

1998 • 102 citations

Intra- and extracellular amyloid fibrils are formed in cultured pancreatic islets of transgenic mice expressing human islet amyloid polypeptide.

1994 • 100 citations

Amyloid and polypeptide hormones: What is their interrelationship?

1994 • 93 citations

Human islet amyloid polypeptide transgenic mice as a model of non‐insulin‐dependent diabetes mellitus (NIDDM)

1993 • 91 citations

Chronic overproduction of islet amyloid polypeptide/amylin in transgenic mice: lysosomal localization of human islet amyloid polypeptide and lack of marked hyperglycaemia or hyperinsulinaemia

1993 • 85 citations

Insulin Resistance versus Insulin Deficiency in Non-Insulin-Dependent Diabetes Mellitus: Problems and Prospects

1998 • 83 citations

B Cell Granule Peptides Affect Human Islet Amyloid Polypeptide (IAPP) Fibril Formationin Vitro

1997 • 76 citations

Intracellular Amyloidogenesis by Human Islet Amyloid Polypeptide Induces Apoptosis in COS-1 Cells

1999 • 69 citations

Induction of apoptosis by human amylin in RINm5F islet β‐cells is associated with enhanced expression of p53 and p21^WAF1/CIP1

1999 • 63 citations

Prolonged exposure of pancreatic beta cells to raised glucose concentrations results in increased cellular content of islet amyloid polypeptide precursors

1999 • 57 citations

Formation of islet amyloid fibrils in beta-secretory granules of transgenic mice expressing human islet amyloid polypeptide/amylin

1995 • 52 citations

Islet amyloid polypeptide (amylin): no evidence of an abnormal precursor sequence in 25 Type 2 (non-insulin-dependent) diabetic patients

1990 • 51 citations

Transgenic overexpression of human islet amyloid polypeptide inhibits insulin secretion and glucose elimination after gastric glucose gavage in mice

1998 • 43 citations

Molecular physiology of the islet amyloid polypeptide (IAPP)/amylin gene in man, rat, and transgenic mice

1994 • 41 citations

Anti-Amyloid Drugs

1996 • 39 citations

Promotion of β-structure by interaction of diabetes associated polypeptide (amylin) with phosphatidylcholine

1992 • 39 citations

Different Sensitivity to the Cytotoxic Action of IAPP Fibrils in Two Insulin-Producing Cell Lines, HIT-T15 and RINm5F Cells

1998 • 36 citations

Differences in amyloid deposition in islets of transgenic mice expressing human islet amyloid polypeptide versus human islets implanted into nude mice

1999 • 36 citations

Non-linkage of the islet amyloid polypeptide gene with Type 2 (non-insulin-dependent) diabetes mellitus

1991 • 34 citations

Changes in Amylin and Amylin-Like Peptide Concentrations ana (β-Cell Function in Response to Sulfonylurea or Insulin Therapy in NIDDM

1998 • 30 citations

Pancreatic expression and secretion of human islet amyloid polypeptide in a transgenic mouse

1994 • 26 citations

IAPP/amylin gene transcriptional control region: evidence for negative regulation

1990 • 26 citations

Investigation of the effects of antisense oligodeoxynucleotides to islet amyloid polypeptide mRNA on insulin release, content and expression

1996 • 13 citations

Effect of insulin treatment on circulating islet amyloid polypeptide in patients with NIDDM

1997 • 10 citations

Reduction of Islet Amylin Expression and Basal Secretion by Adenovirus-Mediated Delivery of Amylin Antisense cDNA

1998 • 10 citations