Anti-Amyloid Drugs

Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

1994 • 1,313 citations

Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus

1994 • 815 citations

Cell Biology of the Amyloid beta-Protein Precursor and the Mechanism of Alzheimer's Disease

1994 • 749 citations

Clinical improvement and amyloid regression after liver transplantation in hereditary transthyretin amyloidosis

1993 • 570 citations

Physiological production of the β-amyloid protein and the mechanism of Alzheimer's disease

1993 • 423 citations

Serum amyloid P component prevents proteolysis of the amyloid fibrils of Alzheimer disease and systemic amyloidosis.

1995 • 418 citations

A kinetic model for amyloid formation in the prion diseases: importance of seeding.

1993 • 391 citations

Arresting amyloidosis in vivo using small-molecule anionic sulphonates or sulphates: implications for Alzheimer's disease

1995 • 358 citations

Amyloid fibril formation requires a chemically discriminating nucleation event: studies of an amyloidogenic sequence from the bacterial protein OsmB

1992 • 319 citations

Amyloid and Amyloidosis 1990

1991 • 255 citations

Binding of the protease-sensitive form of PrP (prion protein) to sulfated glycosaminoglycan and congo red [corrected]

1994 • 230 citations

Potent Inhibition of Scrapie‐Associated PrP Accumulation by Congo Red

1992 • 228 citations

Serum amyloid A changes high density lipoprotein's cellular affinity. A clue to serum amyloid A's principal function.

1992 • 213 citations

Effects of Sulfate Ions on Alzheimer β/A4 Peptide Assemblies: Implications for Amyloid Fibril‐Proteoglycan Interactions

1992 • 211 citations

Interaction of the anthracycline 4'-iodo-4'-deoxydoxorubicin with amyloid fibrils: inhibition of amyloidogenesis.

1995 • 202 citations

Serum amyloid A (SAA): influence on HDL-mediated cellular cholesterol efflux.

1995 • 193 citations

Microangiopathy, the vascular basement membrane and Alzheimer's disease: a review

1990 • 178 citations

Changes in Human Serum Amyloid A and C-Reactive Protein after Etiocholanolone-Induced Inflammation

1978 • 176 citations

Proteoglycan-mediated Inhibition of Aβ Proteolysis

1995 • 171 citations

Circular-dichroism studies on two murine serum amyloid A proteins

1988 • 168 citations

Primary systemic amyloidosis. Comparison of melphalan/prednisone versus colchicine

1985 • 152 citations

The acute phase response: General aspects

1994 • 146 citations

Familial Mediterranean fever: High gene frequency among the non‐Ashkenazic and ashkenazic Jewish populations in Israel

1995 • 143 citations

COLCHICINE TREATMENT OF AA AMYLOIDOSIS OF FAMILIAL MEDITERRANEAN FEVER

1994 • 139 citations

New drug therapy of amyloidoses: resorption of AL-type deposits with 4'- iodo-4'-deoxydoxorubicin

1995 • 136 citations

A chemical approach to elucidate tin mechanism of transthyretin and β-protein amyloid fibril formation

1994 • 124 citations

Islet Amyloid Polypeptide: A Review of Its Biology and Potential Roles in the Pathogenesis of Diabetes Mellitus

1993 • 113 citations

Islet amyloid polypeptide ? a novel controversy in diabetes research

1992 • 106 citations

Sulfated glycosaminoglycans and dyes attenuate the neurotoxic effects of β-amyloid in rat PC12 cells

1995 • 102 citations

Molecular Genetics of Alzheimer Disease: Identification of Genes and Gene Mutations

1995 • 98 citations

Kinetics of amyloid deposition. I. The effects of amyloid-enhancing factor and splenectomy.

1983 • 98 citations

Structural prerequisites for serum amyloid A fibril formation.

1993 • 94 citations

Co-deposition of basement membrane components during the induction of murine splenic AA amyloid.

1991 • 84 citations

Systemic distribution of beta 2-microglobulin-derived amyloidosis in patients who undergo long-term hemodialysis. Report of seven cases and review of the literature.

1994 • 75 citations

An interaction between basement membrane and Alzheimer amyloid precursor proteins suggests a role in the pathogenesis of Alzheimer's disease.

1995 • 74 citations

Treatment of primary amyloidosis.

1995 • 73 citations

Prolonged dimethylsulphoxide treatment in 13 patients with systemic amyloidosis.

1982 • 69 citations

Islet amyloid polypeptide: mechanisms of amyloidogenesis in the pancreatic islets and potential roles in diabetes mellitus.

1992 • 69 citations

Microvascular pathology and vascular basement membrane components in Alzheimer's disease

1994 • 67 citations

THE TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES

1995 • 65 citations

Inhibition of scrapie-associated PrP accumulation

1994 • 54 citations

Acute leukemia and cytogenetic abnormalities complicating melphalan treatment of primary systemic amyloidosis

1990 • 50 citations

Treatment of experimental murine amyloidosis with dimethyl sulfoxide

1977 • 48 citations

Vascular basement membrane components and the lesions of Alzheimer's disease: Light and electron microscopic analyses

1994 • 45 citations

Effect of colchicine on experimental amyloidosis in two CBA/J mouse models. Chronic inflammatory stimulation and administration of amyloid-enhancing factor during acute inflammation.

1985 • 44 citations

Congo Red protects against toxicity of β-amyloid peptides on rat hippocampal neurones

1994 • 42 citations

Resolution of Acquired Factor X Deficiency and Amyloidosis with Melphalan and Prednisone Therapy

1987 • 42 citations

Reversal of nephrotic syndrome due to reactive amyloidosis (AA‐type) after excision of localized Castleman's disease

1994 • 41 citations

Does amyloid enhancing factor (AEF) exist? Is AEF a single biological entity?

1995 • 40 citations

APP processing, Aβ-amyloidogenesis, and the pathogenesis of Alzheimer's disease

1994 • 38 citations

The effect of a liver protein synthesis inhibitor on plasma SAA levels in a model of accelerated amyloid deposition.

1979 • 32 citations

Amyloid and amyloidoses: differences, common themes, and practical considerations.

1991 • 31 citations

Remission of nephrotic syndrome in amyloidosis associated with a hypernephroma.

1989 • 29 citations

Familial mediterranean fever: Analysis of inheritance and current linkage data

1992 • 28 citations

Antibodies to fibronectin bind to plaques and other structures in Alzheimer's disease and control brain

1990 • 25 citations

Nomenclature of amyloid and amyloidosis. WHO-IUIS Nomenclature Sub-Committee.

1993 • 25 citations

Familial Mediterranean fever in the colchicine era: The fate of one family

1993 • 22 citations

Prion protein amyloid and neurodegeneration

1995 • 20 citations

The Resolution of Amyloid Substance

1982 • 18 citations

Chronic exposure of cultured rat pancreatic islets to elevated concentrations of islet amyloid polypeptide (IAPP) causes a decrease in islet DNA content and medium insulin accumulation

1994 • 11 citations

Ethionine carcinogenesis in CD-1, BALB/c and C3H mice

1986 • 11 citations

Combined treatment with terbutaline and aminophylline inhibits experimental amyloidosis in mice

1994 • 8 citations

Familiäres Mittelmeerfieber

2008 • 7 citations

Inhibition of the initiation of hepatic protein synthesis during ethionine mediated ATP depletion in vivo: Modification to ribosomal subunits, evidence of impaired ternary complex formation and a subcellular redistribution of eIF-2 alpha

1990 • 5 citations

A Reappraisal of Current Hypotheses concerning the Possible Roles of Amylin in Physiology, Pathology and Therapeutics

1995 • 5 citations

Deleted Work

1955 • 0 citations